公开(公告)号：EP0934308B1

公开(公告)日：2004-08-11

申请号：EP97927830.6

申请日：1997-06-04

Applicant: Abbott Laboratories

Inventor： LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC: C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  A61K31/44 ,  A61K31/445 ,  A61K31/465 ,  A61K31/505

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

公开(公告)号：EP1339695A1

公开(公告)日：2003-09-03

申请号：EP01273519.7

申请日：2001-11-30

Applicant: Abbott Laboratories

Inventor： CLAIBORNE, Akiyo, K. ,  GWALTNEY, Stephen, L, II ,  HASVOLD, Lisa, A. ,  LI, Qun ,  LI, Tomgmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  ROCKWAY, Todd, W. ,  SHAM, Hing, L. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WANG, Weibo

IPC: C07D233/64 ,  A61K31/4164 ,  C07D401/12 ,  A61P35/00

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：EP0846114A1

公开(公告)日：1998-06-10

申请号：EP96914786.0

申请日：1996-05-28

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B. ,  HE, Yun

IPC: A61K31 ,  A61P25 ,  C07D401 ,  C07D403 ,  C07D417

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP1534692A1

公开(公告)日：2005-06-01

申请号：EP03784917.1

申请日：2003-08-05

Applicant: Abbott Laboratories

Inventor： Li, Goaquan ,  LI, Qun ,  LI, Tongmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  SHAM, Hing, L. ,  WANG, Gary, T.

IPC: C07D241/46 ,  C07D241/20 ,  C07D407/12 ,  C07D401/12 ,  A61K31/4965 ,  A61K31/497 ,  A61P35/00

CPC classification number: C07D241/20

Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making thecompounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1047690B1

公开(公告)日：2004-03-24

申请号：EP98964167.5

申请日：1998-12-18

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP0970083B1

公开(公告)日：2003-04-16

申请号：EP98907359.8

申请日：1998-02-05

Applicant: Abbott Laboratories

Inventor： WASICAK, James, T. ,  GARVEY, David, S. ,  HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B.

IPC: C07D487/04 ,  A61K31/44

CPC classification number: C07D487/04

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having formula (I), wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP1276726A2

公开(公告)日：2003-01-22

申请号：EP01932712.1

申请日：2001-04-25

Applicant: Abbott Laboratories

Inventor： WANG, Wei-Bo ,  CURTIN, Michael, L. ,  FAKHOURY, Stephen, A. ,  GWALTNEY, Stephen, L., II ,  HASVOLD, Lisa A. ,  HUTCHINS, Charles, W. ,  LI, Qui ,  LIN, Nan-Horng ,  JENNINGS NELSON, Lissa, Taka ,  O'CONNOR, Stephen, J. ,  SHAM, Hing, L. ,  SULLIVAN, Gerald, M. ,  WANG, Gary, T. ,  WANG, Xilu

IPC: C07D233/54 ,  A61K31/33 ,  A61P43/00 ,  C07D401/10 ,  C07D249/08 ,  C07D231/12 ,  C07D333/16 ,  C07D409/10 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D213/57 ,  C07D213/74 ,  C07D277/24 ,  C07D213/38 ,  C07D401/14 ,  C07D409/12

CPC classification number: C07D213/30 ,  C07D213/36 ,  C07D231/12 ,  C07D233/64 ,  C07D249/04 ,  C07D249/08 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D333/16 ,  C07D333/24 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D409/10 ,  C07D413/12 ,  C07D417/06

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

公开(公告)号：EP1212319A2

公开(公告)日：2002-06-12

申请号：EP00965070.6

申请日：2000-09-14

Applicant: Abbott Laboratories

Inventor： LIN, Nan-Horng ,  LI, Yihong ,  DRIZIN, Irene ,  KINCAID, John, F. ,  BASHA, Anwer ,  DONG, Liming ,  HAKEEM, Ahmed, A.

IPC: C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  A61K31/4427 ,  A61P25/00

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D409/14

Abstract: A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.

公开(公告)号：EP0846114B1

公开(公告)日：2001-12-05

申请号：EP96914786.7

申请日：1996-05-28

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B. ,  HE, Yun

IPC: C07D401/12 ,  A61K31/44

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP0588917B1

公开(公告)日：2000-11-08

申请号：EP92912971.6

申请日：1992-05-28

Applicant: ABBOTT LABORATORIES

Inventor： GARVEY, David S. ,  CARRERA, George M., Jr. ,  ARNERIC, Stephen P. ,  SHUE, Youe-Kong ,  LIN, Nan-Horng ,  HE, Yun

IPC: C07D413/04 ,  C07D417/04 ,  A61K31/425 ,  A61K31/42

CPC classification number: C07D417/04 ,  C07D413/04

Abstract: Selective and potent nicotinic agonists of formula (I), or pharmaceutically-acceptable salts thereof, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.