公开(公告)号：EP0790970B1

公开(公告)日：1999-06-09

申请号：EP95939080.8

申请日：1995-11-09

Applicant: Abbott Laboratories

Inventor： RILEY, David, A. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steven, A. ,  ROBINSON, Gregg, E.

IPC: C07C29/10 ,  C07C35/16

CPC classification number: C07C69/013 ,  C07C29/095 ,  C07C35/16

Abstract: A method for the preparation D-chiro-inositol (I) from kasugamycin (II), comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

公开(公告)号：EP0915899A1

公开(公告)日：1999-05-19

申请号：EP97934319.0

申请日：1997-07-28

Applicant: Abbott Laboratories

Inventor： LIU, Jih-Hua ,  RILEY, David, A.

IPC: A61K31 ,  A61P31 ,  C07H1 ,  C07H17

CPC classification number: C07H17/08

Abstract: The present invention provides a process for the preparation of 6-O-methylerythromycin A Form II comprising converting erythromycin A to 6-O-methylerythromycin A and treating the 6-O-methylerythromycin A with a number of common organic solvents or mixtures of common organic solvents.

公开(公告)号：EP0915898A1

公开(公告)日：1999-05-19

申请号：EP97934307.0

申请日：1997-07-25

Applicant: Abbott Laboratories

Inventor： LIU, Jih-Hua ,  RILEY, David, A. ,  SPANTON, Stephen, G.

IPC: A61K31 ,  A61P31 ,  C07H17

CPC classification number: C07H17/08

Abstract: The present invention concerns the novel antiobiotic 6-O-methylerythromycin A crystal Form I, a process for its preparation, pharmaceutical compositions comprising this compound and a method of use as a therapeutic agent.