公开(公告)号：EP2134685A1

公开(公告)日：2009-12-23

申请号：EP08745934.3

申请日：2008-04-16

Applicant: Abbott Laboratories

Inventor： BRUNCKO, Milan ,  SONG, Xiaohong ,  DING, Hong ,  TAO, Zhi-fu ,  KUNZER, Aaron R ,  ELMORE, Steven, W. ,  PARK, Cheol-Min ,  MADAR, David ,  WANG, Xilu ,  SOUERS, Andrew, J.

IPC: C07D209/42 ,  C07D403/04 ,  A61K31/404 ,  A61K31/405 ,  A61P35/00

CPC classification number: C07D209/42 ,  C07D403/04

Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic Mcl-1 protein, compositins containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.

公开(公告)号：EP2134684A2

公开(公告)日：2009-12-23

申请号：EP08745970.7

申请日：2008-04-16

Applicant: Abbott Laboratories

Inventor： ELMORE, Steven, W. ,  SOUERS, Andrew, J. ,  BRUNCKO, Milan ,  SONG, Xiaohong ,  WANG, Xilu ,  HASVOLD, Lisa, A. ,  WANG, Le ,  KUNZER, Aaron, R. ,  PARK, Cheol-min ,  WENDT, Michael, D. ,  TAO, Zhi-fu ,  MADAR, David

IPC: C07D209/34 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04 ,  A61P35/00 ,  A61K31/404

CPC classification number: C07D209/42 ,  A61K31/5377 ,  C07D209/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D491/113

Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.

Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。