公开(公告)号：AT271866T

公开(公告)日：2004-08-15

申请号：AT01963002

申请日：2001-09-11

Applicant: BASF AG

Inventor： HASSELWANDER OLIVER ,  KRAEMER KLAUS ,  BALDENIUS KAI-UWE ,  KLATT MARTIN JOCHEN ,  SCHWEIKERT LONI

IPC: A61K31/381 ,  A23L1/30 ,  A61K31/00 ,  A61K31/202 ,  A61K31/385 ,  A61P3/10 ,  A61P9/10 ,  A61P13/12 ,  A61P25/02 ,  A61P27/02 ,  A61K31/20

Abstract: The present invention relates to the use of lipoic acid, a physiologically acceptable derivative or salt thereof and one compound of the formula I H3C-(CH2)n1-(CH=CH)n3-(CH2)n2-COOH I in which n1, n2 have, independently of one another, the value of an integer from 3 to 9, n3 has the value of an integer from 2 to 6, and the number of carbon atoms is 18, 20 or 22, a physiologically acceptable derivative or salt thereof, for nutritional supplementation, in functional foods and for therapeutic purposes in the treatment of diabetic disorders. Compositions having a corresponding active ingredient combination, and compositions in the form of commercial packs with corresponding combination products or single-drug products for combined use are also described.

公开(公告)号：DE10255242A1

公开(公告)日：2004-06-03

申请号：DE10255242

申请日：2002-11-26

Applicant: BASF AG

Inventor： MAIER ULRIKE ,  KLATT MARTIN JOCHEN

IPC: A61P5/50 ,  C07D339/04 ,  B01J20/10 ,  A23L1/30 ,  A61K31/385

Abstract: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

公开(公告)号：DE59905626D1

公开(公告)日：2003-06-26

申请号：DE59905626

申请日：1999-09-17

Applicant: BASF AG

Inventor： STUERMER RAINER ,  KLATT MARTIN JOCHEN ,  BOERMER ARMIN ,  HOLZ JENS ,  VOSS GUDRUN

IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C67/297 ,  C07C67/31 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732

Abstract: Enantiomerically pure beta -hydroxyesters (I) are prepared by asymmetric hydrogenation of a beta -hydroxyester (II) over a ruthenium complex catalyst (III) containing an optically active bidentate bis-phospholane ligand. Preparation of enantiomerically pure beta -hydroxyesters (I) involves reacting a beta -hydroxyester (II) with hydrogen in presence of a ruthenium complex catalyst of formula (III): LRuX2 (III) X = halo, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate; L = bidentate bis-phospholane ligand of formula (A) : Y = bridging group providing 1-5C between the two P atoms; R1 = H, 1-6C alkyl, aryl, alkaryl or Si(R2)3; R2 = alkyl or aryl; m = 0 and R3 = OR4; or m = 1 and R3 = H; R4 = as R1.

公开(公告)号：BR0112848A

公开(公告)日：2003-06-24

申请号：BR0112848

申请日：2001-07-24

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

IPC: A61K31/20 ,  A61P3/10 ,  C07B53/00 ,  C07C303/38 ,  C07C309/66 ,  C07C319/08 ,  C07C319/18 ,  C07C319/28 ,  C07C321/04 ,  C07C323/52 ,  C07D339/04 ,  C07D339/00

Abstract: Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of or its stereoisomer, where Ms is SO 2 -R' and R and R' independently of one another is [sic] C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride, (c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or (d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5, or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.

公开(公告)号：DE10109303A1

公开(公告)日：2002-11-28

申请号：DE10109303

申请日：2001-02-26

Applicant: BASF AG

Inventor： KRAEMER KLAUS ,  KLATT MARTIN JOCHEN

IPC: A61K33/00 ,  A61K31/381

Abstract: A composition (I) comprising at least one mineral salt and (R)- alpha -lipoic acid or (S)- alpha -lipoic acid is claimed. Independent claims are included for (i) a metal - alpha -lipoate, metal- alpha -dihydrolipoate or metal- alpha -lipoic acid complex of formula (1) excluding Mn(Lip )ClO4, Cu(Lip )ClO4, Cd(Lip )ClO4, Pb(Lip )ClO4, Hg(liprac)(OH)2, Hg(DHLrac -), Ni(DHLrac -), Fe2(DHLrac -)3, Zn(Liprac )2(H2O)2 and Cd(Liprac )2(H2O)2. (M)w(Lp)x(A)y(H2O)z (1) M = 1-3 valent, physiologically compatible metal cation; Lp = racemic alpha -lipoic acid or alpha -dihydrolipoic acid, (R)- or (S)- alpha -lipoic or (R)- or (S)- alpha -dihydrolipoic acid, racemic alpha -lipoate or dihydro- alpha -lipoate or (R)- or (S)- alpha -lipoate or (R)- or (S)-dihydro- alpha -lipoate; (A) = physiologically compatible mono- or divalent anion; w = 1 or 2; x = 1-4; y = 0-3; z = 0-6; Lip=monovalent negative racemic, (R)- or (S)- alpha -lipoate; Liprac = monovalent negative racemic alpha -lipoate; Liprac = racemic alpha -lipoic acid; DHLrac = divalent, negative, racemic alpha -dihydrolipoate (ii) compositions comprising a metal - alpha -lipoate, metal- alpha -dihydrolipoate or metal- alpha -lipoic acid complex of formula (1) (iii) the use of alpha -lipoic acid or alpha -dihydrolipoic acid for improving the bioavailability of mineral salts.

公开(公告)号：DK1100793T3

公开(公告)日：2002-10-14

申请号：DK99932864

申请日：1999-07-12

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A23L1/30 ,  A61K31/385 ,  C07B57/00 ,  C07D339/04

Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.

公开(公告)号：DE10038038A1

公开(公告)日：2002-02-21

申请号：DE10038038

申请日：2000-08-02

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

IPC: C07C303/38 ,  C07C309/66 ,  C07C319/18 ,  C07C323/52 ,  C07D339/04 ,  C07C323/04 ,  C07C319/02 ,  C07C319/28

Abstract: R- or S-lipoic acid is produced via R- or S-dihydrolipoic acid which is obtained by reaction of a 6,8-bis(sulfonyloxy)-octanoic acid ester with sodium sulfide and sulfur and treatment with a complex hydride and/or distillation and/or extraction procedures. A 1,6,8-octanetrithiol is also new. Production of R- or S-lipoic acid includes one or more of the following steps: (a) distillation of dihydrolipoic acid; (b) reaction of a 6,8-bis(sulfonyloxy)-octanoic acid ester of formula (I) with sodium sulfide and sulfur in ethanol and treatment with a complex hydride; (c) extraction of a protic solution of R- or S-dihydrolipoic acid with an organic solvent at pH 9-10; or (d) extraction of R- or S-dihydrolipoic acid from a protic solution with an organic solvent at pH 4-5. Ms = SO2-R'; and R,R' = 1-6C alkyl; 3-8C cycloalkyl; 3-8C cycloalkylalkyl; aryl; or aralkyl. Independent claims are also included for: (1) the optically active 1,6,8-octanetrithiol of formula (II) and its stereoisomers (compound (II) is a byproduct which occurs with a (6S)-6,8-dihydroxyoctanoic acid ester used for the preparation of compound (I) and which is obtained by extraction at pH 9): and (2) the conversion of the R- or S-lipoic acid into a salt or derivative.

公开(公告)号：NO20010516A

公开(公告)日：2001-01-30

申请号：NO20010516

申请日：2001-01-30

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A23L1/30 ,  C07D339/04 ,  A61K31/385 ,  C07B57/00

CPC classification number: C07D339/04

公开(公告)号：DE19929367A1

公开(公告)日：2000-12-28

申请号：DE19929367

申请日：1999-06-25

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  MUELLER THOMAS ,  BOCKSTIEGEL BERNHARD

IPC: B01J31/22 ,  B01J31/18 ,  C07B61/00 ,  C07C45/34 ,  C07C49/603 ,  B01J31/12 ,  C07F13/00

Abstract: The preparation of 3,5,5-trimethyl-cyclohex-2-ene-1,4-dione (I) by oxidation of 3,5,5-trimethyl-cyclohex-3-en-1-one (II) with molecular oxygen is catalyzed by a manganese salen complex (III). Preparation of 3,5,5-trimethyl-cyclohex-2-ene-1,4-dione (I) (i.e. oxoisophorone) involves oxidation of 3,5,5-trimethyl-cyclohex-3-en-1-one (II) (i.e. beta -isophorone) with molecular oxygen in presence of a solvent, a base and a manganese salen complex of formula (III) as catalyst. R = H or Cl; M = Mn(II) or Mn(III) .Cl .

公开(公告)号：AU4909499A

公开(公告)日：2000-02-28

申请号：AU4909499

申请日：1999-07-12

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A23L1/30 ,  A61K31/385 ,  C07B57/00 ,  C07D339/04

Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.