公开(公告)号：AU2008311054B2

公开(公告)日：2012-10-18

申请号：AU2008311054

申请日：2008-10-07

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： RISER BRUCE L ,  KAROOR SUJATHA ,  PATEL HIMANSHU D ,  ZIESKE PAUL

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.

公开(公告)号：CA2797138A1

公开(公告)日：2011-10-27

申请号：CA2797138

申请日：2011-04-22

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RISER BRUCE L ,  WHITE JEFFREY A ,  DALTON CHRISTOPHER R

IPC: A61K33/42 ,  A61K9/08 ,  A61P9/10

Abstract: Methods and compositions for reducing, preventing or reducing the progression of calcification in peritoneal dialysis patients are provided. In an embodiment, the present disclosure provides a method comprising administering to a patient during peritoneal dialysis therapy a dialysis solution comprising a therapeutically effective amount of pyrophosphate ranging between about 30 µM and about 400 µM. Formulations of dialysis solutions according to the dose ranges claimed in the present disclosure allow therapeutic amounts of pyrophosphate to be delivered to peritoneal dialysis patients.

公开(公告)号：CO6270333A2

公开(公告)日：2011-04-20

申请号：CO10056067

申请日：2010-05-11

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： RISER BRUCE L ,  ZIESKE PAUL ,  KAROOR SUJATHA ,  PATEL HIMANSHU

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/10 ,  A61P7/08

Abstract: Se proporcionan soluciones para dialisis que comprenden pirofosfatos y métodos para elaborar y utilizar las soluciones para dialisis. En una modalidad, la presente descripcion suministra unas soluciones para dialisis que comprenden una cantidad estable y terapéuticamente efectiva de pirofosfatos. La solucion para dialisis se puede esterilizar, por ejemplo, utilizando una técnica tal como autoclave, vapor, alta presion, rayos ultra-violeta, filtracion o una combinacion de las mismas. La solucion para dialisis puede estar en la forma de un concentrado.

公开(公告)号：AU2008311054A1

公开(公告)日：2009-04-16

申请号：AU2008311054

申请日：2008-10-07

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： ZIESKE PAUL ,  KAROOR SUJATHA ,  RISER BRUCE L ,  PATEL HIMANSHU D

IPC: A61K33/42 ,  A61L2/02 ,  A61L2/04 ,  A61L2/07 ,  A61L2/10 ,  A61M1/16 ,  A61M1/28 ,  A61P7/08

Abstract: Dialysis solutions comprising pyrophosphates and methods of making and using the dialysis solutions are provided. In an embodiment, the present disclosure provides a dialysis solution comprising a stable and therapeutically effective amount of pyrophosphate. The dialysis solution can be sterilized, for example, using a technique such as autoclave, steam, high pressure, ultra-violet, filtration or combination thereof. The dialysis solution can be in the form of a concentrate.