公开(公告)号：WO2010048275A2

公开(公告)日：2010-04-29

申请号：PCT/US2009061470

申请日：2009-10-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  SCHNECKER KURT ,  HAIDWEGER EVA ,  TURECEK PETER

Inventor： SCHNECKER KURT ,  HAIDWEGER EVA ,  TURECEK PETER

IPC: A61K38/16

CPC classification number: A61K38/36 ,  A61K9/08 ,  A61K9/19 ,  A61K38/16 ,  A61K38/17 ,  A61K47/12 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26

Abstract: The present invention provides long-term stable pharmaceutical formulations of lyophilized recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations.

Abstract translation: 本发明提供了冻干重组血管性血友病因子（rVWF）的长期稳定的药物制剂以及制备和施用所述制剂的方法。

公开(公告)号：WO2010014708A3

公开(公告)日：2010-04-22

申请号：PCT/US2009052103

申请日：2009-07-29

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  TURECEK PETER ,  SIEKMANN JUERGEN

Inventor： TURECEK PETER ,  SIEKMANN JUERGEN

IPC: A61K47/48 ,  C07K14/755

CPC classification number: A61K47/4823 ,  A61K38/00 ,  A61K38/37 ,  A61K47/48215 ,  A61K47/60 ,  A61K47/61 ,  C07K14/745

Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same. In one embodiment of the invention, the water-soluble polymer is selected from the group consisting of polyethylene glycol (PEG), polysialic acid (PSA) or dextran.

Abstract translation: 本发明是一种蛋白质构建体，其包含通过因子VIII的碳水化合物部分与水溶性聚合物缀合的因子VIII分子及其制备方法。 在本发明的一个实施方案中，水溶性聚合物选自聚乙二醇（PEG），聚唾液酸（PSA）或葡聚糖。

公开(公告)号：WO2009086356A2

公开(公告)日：2009-07-09

申请号：PCT/US2008088131

申请日：2008-12-23

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  TURECEK PETER ,  SIEKMANN JUERGEN ,  WEBER ALFRED ,  GRITSCH HERBERT ,  VARADI KATALIN ,  VEJDA SUSANNE

Inventor： TURECEK PETER ,  SIEKMANN JUERGEN ,  WEBER ALFRED ,  GRITSCH HERBERT ,  VARADI KATALIN ,  VEJDA SUSANNE

IPC: G01N33/53

CPC classification number: G01N33/86 ,  G01N33/5308 ,  G01N2430/60

Abstract: The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.

Abstract translation: 本发明涉及测定与蛋白质结合的生理上可接受的聚合物分子的量，能够特异性结合生理上可接受的聚合物分子的抗体或其它组合物的方法，以及含有所述抗体或组合物的试剂盒。

公开(公告)号：WO2008082669A3

公开(公告)日：2009-04-09

申请号：PCT/US2007026522

申请日：2007-12-27

Applicant: NEKTAR THERAPEUTICS AL CORP ,  BAXTER INT ,  BAXTER HEALTHCARE SA ,  BOSSARD MARY J ,  STEPHENSON GAYLE ,  FANG ZHIHAO ,  ZAPPE HAROLD ,  MITCHELL STACY ,  ZHANG PING ,  SCHEIFLINGER FRITZ ,  TURECEK PETER ,  SIEKMANN JUERGEN ,  VARADI KATALIN ,  GRITSCH HERBERT

Inventor： BOSSARD MARY J ,  STEPHENSON GAYLE ,  FANG ZHIHAO ,  ZAPPE HAROLD ,  MITCHELL STACY ,  ZHANG PING ,  SCHEIFLINGER FRITZ ,  TURECEK PETER ,  SIEKMANN JUERGEN ,  VARADI KATALIN ,  GRITSCH HERBERT

IPC: A61K47/48 ,  A61P7/00

CPC classification number: C07K14/755 ,  A61K47/60

Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.

Abstract translation: 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。

公开(公告)号：WO2005095638B1

公开(公告)日：2006-11-02

申请号：PCT/EP2005003328

申请日：2005-03-30

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  VARADI KATALIN ,  TURECEK PETER ,  KEIL BRIGITTE ,  PEYRER-HEIMSTAETT SYLVIA ,  SCHWARZ HANS-PETER

Inventor： VARADI KATALIN ,  TURECEK PETER ,  KEIL BRIGITTE ,  PEYRER-HEIMSTAETT SYLVIA ,  SCHWARZ HANS-PETER

IPC: C12Q1/56 ,  G01N33/86

CPC classification number: A61K31/66 ,  C12Q1/56 ,  G01N33/86 ,  G01N2333/745

Abstract: The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl 2 . The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.

Abstract translation: 本发明提供了一种用于测量患者血液或血浆样品或凝血因子样品中的凝血酶产生的试剂盒。 试剂盒含有冻干组织因子/磷脂复合物和含有凝血酶底物和CaCl 2 2的冻干混合物。 本发明还提供了用于制备试剂盒的试剂的方法。 该试剂盒可以用于测量样品中凝血酶产生的方法，其中可以检测凝血酶产生动力学的变化，例如在将抑制剂旁路剂施用于已经开发出外源凝血因子的抑制剂的患者之后 作为因子VIII。

公开(公告)号：BR112013001611B1

公开(公告)日：2022-05-10

申请号：BR112013001611

申请日：2011-07-29

Applicant: BAXALTA GMBH ,  BAXALTA INC ,  BAXTER HEALTHCARE SA ,  BAXTER INT ,  TAKEDA PHARMACEUTICALS CO

Inventor： IVENS ANDREAS ,  ROTTENSTEINER HANSPETER ,  SIEKMANN JUERGEN ,  ZOECHLING OLIVER ,  TURECEK PETER ,  HAIDER STEFAN

IPC: A61K47/60 ,  A61K47/61

Abstract: métodos para conjugar um polímero solúvel em água a uma fração de carboidrato oxidado de uma proteína terapêutica, para formar uma ligação oxima entre uma fração de carboidrato oxidado em uma proteína terapêutica e um polímero solúvel em água ativado, e para formar uma ligação hidrazona entre uma fração de carboidrato oxidado em uma proteína terapêutica e um polímero solúvel em água ativado, e, proteína terapêutica modificada. a invenção se refere a materiais e métodos de conjugação de um polímero solúvel a materiais e métodos de conjugação de um polímero solúvel em água a uma fração de carboidrato oxidado de uma proteína terapêutica solúvel em água a uma fração de carboidrato oxidado de uma proteína terapêutica compreendendo contatar a fração de carboidrato oxidado com um polímero solúvel em água ativado em condições que permitem conjugação. mais especificamente, a presente invenção se refere aos materiais e métodos acima mencionados em que o polímero solúvel em água contém um grupo amino-óxi ativo e em que uma ligação oxima ou hidrazona é formada entre a fração de carboidrato oxidado e o grupo amino-óxi ativo no polímero solúvel em água, e em que a conjugação é conduzida na presença de um catalisador nucleofílico.

公开(公告)号：CA2745805C

公开(公告)日：2021-01-19

申请号：CA2745805

申请日：2009-12-03

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： VARADI KATALIN ,  ROTTENSTEINER HANSPETER ,  TURECEK PETER ,  SCHWARZ HANS-PETER ,  SCHREINER JUTTA

IPC: C12Q1/37 ,  G01N1/28 ,  G01N33/48 ,  G01N33/483 ,  G01N33/53 ,  G01N33/577

Abstract: The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS1 3 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.

公开(公告)号：SG10201913078SA

公开(公告)日：2020-02-27

申请号：SG10201913078S

申请日：2011-07-29

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： SIEKMANN JUERGEN ,  HAIDER STEFAN ,  ROTTENSTEINER HANSPETER ,  IVENS ANDREAS ,  TURECEK PETER ,  ZOECHLING OLIVER

Abstract: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.

公开(公告)号：NO342710B1

公开(公告)日：2018-07-23

申请号：NO20092257

申请日：2009-06-11

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  NEKTAR THERAPEUTICS

Inventor： BOSSARD MARY J ,  VARADI KATALIN ,  GRITSCH HERBERT ,  FANG ZHIHAO ,  ZAPPE HAROLD ,  MITCHELL STACY ,  ZHANG PING ,  SCHEIFLINGER FRIEDRICH ,  TURECEK PETER ,  SIEKMANN JUERGEN ,  STEPHENSON GAYLE

IPC: C07K14/755

Abstract: Foreliggende oppfinnelse tilveiebringer von Willebrand Faktor-polymerkonjugater og Faktor VIII-polymerkonjugater idet hver har en frigjørbar binding. Metoder for fremstilling av konjugater og metoder for administrering av konjugater er også gitt.

公开(公告)号：CA2746125C

公开(公告)日：2017-07-11

申请号：CA2746125

申请日：2009-12-11

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： WEBER ALFRED ,  HOEFINGHOFF JORIS ,  SIEKMANN JUERGEN ,  TURECEK PETER

IPC: G01N33/86 ,  G01N21/00 ,  G01N33/487 ,  G01N33/68

Abstract: The present invention relates, in general, to methods for detecting the amount of a polymer on a protein using nearinfrared spectroscopy. Measurement of the number of polymer moieties per protein molecule allows for production of molecules having a uniform number of polymer moieties, which is useful in the production of pharmaceutical compositions.