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    INSULATING DEVICE FOR A MACHINE ELEMENT, IN PARTICULAR AN EXHAUST GAS PIPE
    21.
    发明申请
    INSULATING DEVICE FOR A MACHINE ELEMENT, IN PARTICULAR AN EXHAUST GAS PIPE 审中-公开
    用绝缘的机械元件，尤其是排气管

    公开(公告)号：WO2008145374A2

    公开(公告)日：2008-12-04

    申请号：PCT/EP2008004307

    申请日：2008-05-30

    Applicant: BDD BETEILIGUNGS GMBH ,  BECKER MICHAEL

    Inventor： BECKER MICHAEL

    IPC: F01N13/14

    CPC classification number: B60R13/0876 ,  B60R13/0838 ,  F01N13/102 ,  F01N13/14 ,  F01N2260/20 ,  F02M39/00

    Abstract: The invention relates to an insulating device containing a first machine element (6), in particular an exhaust gas pipe, and at least one second machine element (8), in particular an exhaust manifold, that is connected to said first machine element and through which, in particular, a hot medium can flow and being connected to a unit (2). The insulating device at least partially surrounds the machine element (6) and is connected to the unit (2). The aim of the invention is to further develop the claimed insulating device with a low amount of production and material expenditure such that mounting and demounting can be carried out in a simple manner and can be adapted in a problem-free manner to various types of units. According to the invention, a base plate (10) that is connected to the unit (2) is provided, said base plate having at least two side parts (18) that are arranged at a distance from each other forming an intermediate area (28), such that a sliding part (20) is arranged in the intermediate area (28) and is essentially sealingly connected the base plate (10) and to the lateral parts (18) by means of profiles (30, 32) and is detachably connected in relation to the base plate (10), such that said sliding part (20) contains a recess (36) through which the second machine element (8) is guided, and also a cover (14) that can be connected to the base plate (10) by means of a detachable securing element (16), said cover engaging with the first machine element (6). The cover (14) rests upon the lower edges thereof (15) on associated areas of the lateral parts (18) of the base plate (10) and/or the sliding part(s) (20).

    Abstract translation: 绝缘装置包括连接到第一机床构件（6），特别是排气管，以及至少一个第二机床构件后者（8），特别是排气歧管，其通过一个特别热的介质连接的可以流动并与单元（2）。 所述绝缘装置包围机器元件（6）至少部分地，并且被固定（2）固定在机器上。 该隔离装置被开发以低的生产和/或材料成本，一个简单的组装或拆卸成为可能，并可以做到容易地适用于不同形状的聚集体的影响。 为了这个目的，它提出了一个与所述单元（2）连接到所述底板（10）被提供，其具有至少两个以形成中间空间（28）间隔开的侧片（18），即在中间空间（28）的插入部分（20） 布置，其连接到与所述基座板（10）基本上被密封和底板（10）的侧部（18）由型材的装置（30，32）被设计成是可拆卸的相对于所述插入部（20）包括凹部（36） 通过该第二机械元件（8）被引导经过其，和可释放的紧固元件（16）与基板的进一步的装置（10）连接的盖（14）被提供，其接合在所述第一机床构件（6），其中，所述罩（ 14）与它们的下边缘（15）（在该底板（10）和/或所述或插入零件的侧面部分18）的分配区域（20）搁置。

    CATALYST AND METHOD FOR HYDROGENATING ORGANIC COMPOUNDS CONTAINING HYDROGENABLE GROUPS
    22.
    发明申请
    CATALYST AND METHOD FOR HYDROGENATING ORGANIC COMPOUNDS CONTAINING HYDROGENABLE GROUPS 审中-公开
    钌催化剂和氢化方法来说氢化基团含有机物的

    公开(公告)号：WO2006136541A3

    公开(公告)日：2007-04-12

    申请号：PCT/EP2006063323

    申请日：2006-06-20

    Applicant: BASF AG ,  VAN LAAR FREDERIK ,  BECKER MICHAEL ,  SCHWAB EKKEHARD ,  HENKELMANN JOCHEM ,  POLANEK PETER

    Inventor： VAN LAAR FREDERIK ,  BECKER MICHAEL ,  SCHWAB EKKEHARD ,  HENKELMANN JOCHEM ,  POLANEK PETER

    IPC: B01J21/08 ,  B01J23/46 ,  B01J23/656 ,  B01J35/10 ,  B01J37/02 ,  C07B35/00

    CPC classification number: B01J23/462 ,  B01J21/08 ,  B01J35/1019 ,  B01J37/0205

    Abstract: The invention relates to a shell catalyst containing ruthenium as an active metal, alone or together with at least one other metal of the auxiliary group IB, VIIB or VIII of the periodical system of the elements (CAS version), and applied to a carrier containing silicon dioxide as a carrier material. The invention also relates to a method for producing said shell catalyst, and to a method for hydrogenating an organic compound containing hydrogenable groups, preferably for hydrogenating a carbocyclic aromatic group to form the corresponding carbocyclic aliphatic groups or for hydrogenating aldehydes to form the corresponding alcohols, using the inventive shell catalyst. The invention further relates to the use of the inventive shell catalyst for hydrogenating an organic compound containing hydrogenable groups, preferably for hydrogenating a carbocyclic aromatic group to form the corresponding carbocyclic aliphatic groups or for hydrogenating aldehydes to form the corresponding alcohols.

    Abstract translation: 本发明涉及一种含有壳催化剂作为活性金属钌单独或与过渡族IB，VIIB中的至少一种另外的金属或元素（CAS版本）的周期表第VIII一起施加到载体包括二氧化硅作为载体材料，用于制造这种壳催化剂的方法 含有氢化的有机化合物，可氢化基团，优选为碳环芳族基团的氢化成相应的碳环脂族基团或用于根据本发明和根据本发明的用于氢化的使用涂层催化剂的醛氢化成相应的醇，该涂层催化剂的Verwendüng下的处理 含有氢化的基团，优选为碳环基团aromatichen的氢化成相应的碳环脂族基团或氢化的有机化合物 醛为相应的醇的UNG。

    DIAGNOSIS AND THERAPY OF BREAST TUMOURS RESISTANT TO ANTIESTROGEN TREATMENT
    23.
    发明申请
    DIAGNOSIS AND THERAPY OF BREAST TUMOURS RESISTANT TO ANTIESTROGEN TREATMENT 审中-公开
    乳腺肿瘤的诊断和治疗抗静脉治疗

    公开(公告)号：WO2004008137A3

    公开(公告)日：2004-09-02

    申请号：PCT/EP0307449

    申请日：2003-07-10

    Applicant: MAX DELBRUECK CENTRUM ,  CT FOR GENETIC ENGINEERING AND ,  FICHTNER IDUNA ,  BECKER MICHAEL ,  BESADA PEREZ VLADIMIR ,  CASTELLANOS SERRA LILA

    Inventor： FICHTNER IDUNA ,  BECKER MICHAEL ,  BESADA PEREZ VLADIMIR ,  CASTELLANOS SERRA LILA

    IPC: A61P35/00 ,  G01N33/50 ,  G01N33/574 ,  C12Q1/68

    CPC classification number: G01N33/57415 ,  G01N33/5011

    Abstract: The invention is about a method to diagnose and therapy breast tumors resistant to antiestrogen treatment by using specific target proteins and the nucleic acids encoding these proteins. The method is based on the determination of the differential expression of specific target genes on the nucleic acids and protein level in antiestrogen-resistant breast tumor cells. Fields of application exist in medicine and in the pharmaceutical industry. The method is characterized by the fact, that the concentration of at least one specific target protein is determined in tumor tissue and is compared with the standard reference value of the same protein or proteins in breast tumor tissue sensitive to antiestrogen treatment, whereat a protein concentration of the sample examined lying above the standard reference value indicates tumor resistance to antiestrogen treatment, provided it is a protein which is expressed at a higher level in breast tumor cells resistant to antiestrogen treatment, as compared to breast tumor cells sensitive to antiestrogen treatment, or a protein concentration of the sample examined lying below the standard reference value indicates tumor resistance to antiestrogen treatment, provided it is a protein which is expressed at a lower level in breast tumor cells resistant to antiestrogen treatment, as compared to breast tumor cells sensitive to antiestrogen treatment.

    Abstract translation: 本发明涉及一种通过使用特异性靶蛋白和编码这些蛋白质的核酸来诊断和治疗耐抗雌激素治疗的乳腺肿瘤的方法。 该方法基于特异性靶基因在抗雌激素抗性乳腺肿瘤细胞中的核酸和蛋白质水平的差异表达的确定。 应用领域存在于医药和制药行业。 该方法的特征在于，在肿瘤组织中确定至少一种特异性靶蛋白的浓度，并将其与对抗雌激素治疗敏感的乳腺肿瘤组织中相同蛋白质或蛋白质的标准参考值进行比较，其中蛋白质浓度 与标准参考值相比高于标准参考值的样品表明，与抗雌激素治疗敏感的乳腺肿瘤细胞相比，具有抗雌激素治疗的肿瘤耐药性，只要它是对抗雌激素治疗有效的乳腺肿瘤细胞中较高水平表达的蛋白质，或 与标准参考值相比，检测的样品的蛋白质浓度表示抗肿瘤抗药性，只要它是对抗雌激素治疗敏感的乳腺肿瘤细胞的乳腺肿瘤细胞中较低水平表达的蛋白质。 治疗。

    Infusionsvorrichtung
    24.
    发明专利
    Infusionsvorrichtung 未知

    公开(公告)号：DE102021117940A1

    公开(公告)日：2023-01-12

    申请号：DE102021117940

    申请日：2021-07-12

    Applicant: BECKER MICHAEL

    Inventor： BECKER MICHAEL

    IPC: G06F17/10 ,  A61B5/00 ,  A61M16/01 ,  G16H40/60

    Abstract: Bei einem Verfahren zur Bestimmung eines multimodalen (Patienten -) Zustandes- wird ein aktueller (Patienten-) Zustand bestehend aus Daten von mindestens zwei unimodalen Zustands-Indikatoren Xkmit k= 1; ...; n und n ≥ 2 gemessen oder berechnet;- existiert ein historischer (Populations-) Datensatz mit Daten von mindestens zwei Zustands-Indikatoren Xkund mindestens einem Referenz-Indikator X0;- besteht zwischen den mindestens zwei Zustands-Indikatoren einerseits und dem mindestens einen Referenz-Indikator andererseits eine Korrelation;- spannen die mindestens zwei Zustands-Indikatoren Xkund der mindestens eine Referenz-Indikator X0einen orthogonalen Zustandsraum auf;- werden Regressions-Funktionen im Zustandsraum mit dem historischen (Populations-) Datensatz berechnet, die den mindestens einen Referenz-Indikator X0als unabhängige Variable enthalten;- und für einen aktuellen (Patienten-) Zustand wird mit den Regressionsfunktionen mindestens ein aktueller, n-modaler (n ≥ 2) Erwartungswert µnMdes aktuell nicht bekannten Referenzwertes auf mindestens einer Referenz-Achse X0des Zustandsraumes berechnet.

    28.
    发明专利
    未知

    公开(公告)号：DE2812729A1

    公开(公告)日：1979-09-27

    申请号：DE2812729

    申请日：1978-03-23

    Applicant: BECKER MICHAEL

    Inventor： BECKER MICHAEL

    IPC: A61M5/178 ,  A61M5/20 ,  A61M5/315

    Abstract: A pistol-like casing provides for mounting a tubular holder containing a syringe in the gun barrel portion of the casing so it may be cocked in the withdrawn position against the force of a spring and released by movement of an arresting pawl. Pulling back a trigger advances a push rod that first trips the pawl, then brings force to bear against the piston rod of the syringe. After the needle is driven into the skin by the release of the pawl and the actuating mechanism has been brought to bear against the syringe piston-rod, the injection of the syringe contents can proceed under control of hand feel without any necessity of changing or shifting the hand grip, by simply continuing to pull the trigger back.

    Improvements in Screwing Taps.
    29.
    发明专利
    Improvements in Screwing Taps. 未知

    公开(公告)号：GB190322341A

    公开(公告)日：1904-02-04

    申请号：GB190322341D

    申请日：1903-10-16

    Applicant: BECKER MICHAEL

    Inventor： BECKER MICHAEL

    Abstract: 22,341. Becker, M. Oct. 16. Taps.-The retractable cutters f of a screwing- tap are arranged in radial slots in a support d, and engage in dovetailed grooves in a tapered plug g which is moved longitudinally by a screwed spindle b extending through the shank or sleeve a. A ring h, carrying guiding-pins which take into recesses in the cutters, and which is held on the plug by nuts i, secures the cutters in position.

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