公开(公告)号：EP2499127B1

公开(公告)日：2018-09-05

申请号：EP10779605.4

申请日：2010-11-05

Applicant: Bristol-Myers Squibb Company

Inventor： LAVOIE, Rico ,  BENDER, John A. ,  YANG, Zhong ,  BELEMA, Makonen ,  LOPEZ, Omar D. ,  CHEN, Qi ,  WANG, Gan ,  HEWAWASAM, Piyasena

IPC: C07D405/14 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D413/14 ,  A61K45/06 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  C07D403/10 ,  C07D309/06 ,  A61K31/4375

CPC classification number: C07D309/06 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：EP3019196B1

公开(公告)日：2018-06-06

申请号：EP13740435.6

申请日：2013-07-09

Applicant: Bristol-Myers Squibb Company

Inventor： HEWAWASAM, Piyasena ,  LOPEZ, Omar D. ,  TU, Yong ,  WANG, Alan Xiangdong ,  XU, Ningning ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  GUPTA, Samayamunthula Venkata Satya Arun Kumar ,  KUMAR, Indasi J. Gopi ,  PUNUGUPATI, Suresh Kumar ,  BELEMA, Makonen

IPC: A61K45/06 ,  A61K31/4164 ,  A61K31/4178 ,  A61P31/14

CPC classification number: A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/695 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

公开(公告)号：EP2414350B1

公开(公告)日：2014-11-12

申请号：EP10722818.1

申请日：2010-03-24

Applicant: Bristol-Myers Squibb Company

Inventor： BENDER, John A. ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  LOPEZ, Omar D. ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  WANG, Gan ,  XU, Ningning ,  BELEMA, Makonen

IPC: C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D403/04 ,  C07D403/14 ,  C07D405/14

公开(公告)号：EP2435425B1

公开(公告)日：2014-10-15

申请号：EP10724195.2

申请日：2010-05-20

Applicant: Bristol-Myers Squibb Company

Inventor： LOPEZ, Omar D. ,  CHEN, Qi ,  BELEMA, Makonen

IPC: C07D403/14 ,  A61K31/4178 ,  A61P31/12

CPC classification number: C07D403/14

公开(公告)号：EP2707365A1

公开(公告)日：2014-03-19

申请号：EP12723010.0

申请日：2012-05-09

Applicant: Bristol-Myers Squibb Company

Inventor： CHEN, Qi ,  LOPEZ, Omar D. ,  BENDER, John A. ,  WANG, Gan ,  NGUYEN, Van N. ,  KADOW, John F. ,  MEANWELL, Nicholas A. ,  BELEMA, Makonen

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4178 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗以下方案（I）的丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：EP2049114A2

公开(公告)日：2009-04-22

申请号：EP07813926.8

申请日：2007-08-09

Applicant: Bristol-Myers Squibb Company

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  HAMANN, Lawrence G.

IPC: A61K31/501 ,  A61K31/506 ,  A61K31/497 ,  A61P31/12

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07F7/10

Abstract: The present disclosure relates to compounds of formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：EP2499132B1

公开(公告)日：2017-02-15

申请号：EP10779401.8

申请日：2010-11-10

Applicant: Bristol-Myers Squibb Company

Inventor： LAVOIE, Rico ,  BENDER, John A. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  BACHAND, Carol ,  LOPEZ, Omar D. ,  CHEN, Qi ,  BELEMA, Makonen ,  KADOW, John F. ,  HAMANN, Lawrence G.

IPC: C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D493/08

CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/10 ,  C07D419/10 ,  C07D493/08

公开(公告)号：EP2242751B1

公开(公告)日：2015-07-15

申请号：EP09711416.9

申请日：2009-02-10

Applicant: Bristol-Myers Squibb Company

Inventor： BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  A61K31/517 ,  A61P31/00

CPC classification number: C07D403/14

公开(公告)号：EP2603504A1

公开(公告)日：2013-06-19

申请号：EP11750005.8

申请日：2011-08-10

Applicant: Bristol-Myers Squibb Company ,  Srinivasu, Pothukanuri ,  Gupta, Samayamunthula Venkata Satya Arun Kumar

Inventor： SRINIVASU, Pothukanuri ,  GUPTA, Samayamunthula Venkata Satya Arun Kumar ,  BELEMA, Makonen ,  BENDER, John A. ,  LOPEZ, Omar D. ,  CHEN, Qi ,  RAMPULLA, Richard A. ,  MEANWELL, Nicholas A.

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  A61K31/4178 ,  A61K31/433 ,  A61P31/12

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：EP2499132A1

公开(公告)日：2012-09-19

申请号：EP10779401.8

申请日：2010-11-10

Applicant: Bristol-Myers Squibb Company

Inventor： LAVOIE, Rico ,  BENDER, John A. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  BACHAND, Carol ,  LOPEZ, Omar D. ,  CHEN, Qi ,  BELEMA, Makonen ,  KADOW, John F. ,  HAMANN, Lawrence G.

IPC: C07D403/06 ,  C07D403/10 ,  C07D417/10 ,  C07D419/10 ,  C07D417/02 ,  C07D419/02 ,  A61K31/4178

CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/10 ,  C07D419/10 ,  C07D493/08

Abstract: This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

Abstract translation: 本公开涉及式（I）的新化合物或如说明书中定义的新化合物和包含此类新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是在抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能中。 因此，本公开还涉及通过使用这些新化合物或包含这种新化合物的组合物来治疗HCV相关疾病或病症的方法。