公开(公告)号：CA2100559A1

公开(公告)日：1992-08-01

申请号：CA2100559

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A ,  ESCOBEDO JAIME A ,  WILLIAMS LEWIS T

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12N15/18 ,  G01N33/74

Abstract: 2100559 9213867 PCTABS00014 Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening or ligand analogues.