Abstract:
The invention relates to the transfer and distribution, notably in a biological or chemical analysis, of a small amount of liquid. The invention relates notably to a method which consists of providing a transfer tool (18) having at least one rod (10) whose lower surface (12) of pre-determined cross section is wettable and of which at least one side surface (14) is non-wettable; immersing the rod (10) into a reservoir containing a liquid, for a pre-determined period of time and at a pre-determined depth; removing the rod (10) from the reservoir so that a liquid drop is retained on the lower surface (12) of the rod (10); positioning the rod (10) over a receptor medium; and placing the drop in contact with a surface of a receptor medium. The invention also relates to the transfer tool (18) which has in its structure at least one rod (10) and to a method for making the transfer tool (18).
Abstract:
Production of a coating of molecular thickness on a three-dimensional substrate by dry-transfer of a compound having an affinity for that substrate, is new. A surface of a transfer element is brought into contact with the substrate, the surface being at least partly impregnated with the compound. A transfer element whose surface is flat and uniformly impregnated is placed in contact with a substrate containing relatively high exposed parts and relatively low recessed parts. The compound/coating is selectively applied onto the relatively high exposed parts of the substrate, leaving the relatively low recessed parts essentially free of compound.
Abstract:
A substrate for use in supporting high density biological or chemical arrays that is made from borosilicate or boroaluminosilicate glass. It has been demonstrated that a functionalized coating used to immobilize oligonucleotides for example, retains its functionality when exposed to environmental stresses when it is applied to a slide composed of a glass material having a low sodium oxide content.
Abstract:
The invention comprises using, providing and making at least one transfer rod (10) of radius (R) having a wettable lower surface (12) upon which a liquid drop (16) to be transferred may form. Rod (10) has a non-wettable side surface (14). Initially after molding rod (10) is entierly non-wettable but it is post treated so at least lower surface (12) is wettable.