公开(公告)号：CA2823772A1

公开(公告)日：2012-07-12

申请号：CA2823772

申请日：2012-01-06

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: B32B5/16

Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.

公开(公告)号：CA2823953C

公开(公告)日：2023-01-03

申请号：CA2823953

申请日：2012-01-06

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: A01N1/02 ,  A61M1/02 ,  B01J20/26

Abstract: Methods of treating blood, blood products or physiologic fluid maximize shelf life and/or minimize transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent. The blood purification devices comprise: (a) a compliant container suitable for the storage of blood, blood product or physiologic fluid; (b) sorbent comprising hemocompatible material suitable for treating blood, blood product or physiologic fluid, the sorbent performing at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; where the sorbent is contained within the compliant container.

公开(公告)号：MX342421B

公开(公告)日：2016-09-28

申请号：MX2012011305

申请日：2011-04-01

Applicant: CYTOSORBENTS CORP *

Inventor： CHAN PHILLIP P ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  BARTLETT ROBERT H ,  HUMAYRA BEGUM ALI

IPC: A61K31/74 ,  A61P19/00 ,  A61P29/00

Abstract: La presente invención es concerniente con métodos de tratamiento de inflamación sistémica, regional o local de un paciente que sufre o está en riesgo de inflamación que comprende la administración de una dosis terapéuticamente efectiva de un sorbente que absorbe un mediador inflamatorio en dicho paciente. En algunas modalidades preferidas, el sorbente es un polímero orgánico biocompartible.

公开(公告)号：CA2877536A1

公开(公告)日：2014-01-03

申请号：CA2877536

申请日：2013-06-28

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: A61M1/34 ,  C09K23/38 ,  C09K23/48 ,  C09K23/52

Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

公开(公告)号：AU2012204277A1

公开(公告)日：2013-07-18

申请号：AU2012204277

申请日：2012-01-06

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: B32B5/16

Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.

公开(公告)号：CA2844688A1

公开(公告)日：2013-02-21

申请号：CA2844688

申请日：2012-08-10

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: A01N1/02 ,  A61K35/14

Abstract: The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.

公开(公告)号：PL2866854T3

公开(公告)日：2021-01-11

申请号：PL13810619

申请日：2013-06-28

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: A61K9/16 ,  A61M1/34 ,  A61K31/765 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28 ,  C08F299/00 ,  C08J9/26 ,  C09K23/38 ,  C09K23/48 ,  C09K23/52

公开(公告)号：CA2877536C

公开(公告)日：2020-12-29

申请号：CA2877536

申请日：2013-06-28

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: A61K31/765 ,  A61K9/14 ,  A61P7/00 ,  A61P39/00 ,  A61P39/04 ,  C09K23/38 ,  C09K23/48 ,  C09K23/52

Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

公开(公告)号：AU2011234978B2

公开(公告)日：2016-03-17

申请号：AU2011234978

申请日：2011-04-01

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  YOUNG WEI-TAI ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  BARLETT ROBERT H ,  ALI HUMAYRA BEGUM

IPC: A61K31/74

Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.

公开(公告)号：AU2012204277B2

公开(公告)日：2015-11-05

申请号：AU2012204277

申请日：2012-01-06

Applicant: CYTOSORBENTS CORP

Inventor： CHAN PHILLIP P ,  CAPPONI VINCENT J ,  GOLOBISH THOMAS D ,  ALI HUMAYRA BEGUM

IPC: B32B5/16

Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.