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    CARDIOACTIVE OXYDO-BUFADIENOLIDE AND PROCESS FOR PREPARING IT
    24.
    发明专利
    CARDIOACTIVE OXYDO-BUFADIENOLIDE AND PROCESS FOR PREPARING IT 未知

    公开(公告)号：CA929157A

    公开(公告)日：1973-06-26

    申请号：CA109542

    申请日：1971-04-05

    Applicant: HOECHST AG

    Inventor： STACHE U ,  LINDNER E ,  RADSCHEIT K ,  HAEDE W ,  FRITSCH W

    IPC: A61K31/70 ,  C07J71/00

    Abstract: 1315235 Bufapolyenolides FARBWERKE HOECHST AG 19 April 1971 [8 April 1970] 26359/71 Heading C2U The novel compound 3#-(α-L-rhamnopyranosyloxy) - 14,15# - epoxy - 14# - bufa - 4,20,22- trienolide is prepared from proscillaridin by successively acylating the three sugar hydroxy groups, dehydrating in the 14,15-position, adding hypohalous acid acoross the resulting # 14 - double bond, dehydrohalogenating the resulting 14#-hydroxy-15α-halo grouping, and lastly liberating the three sugar hydroxy groups by saponification. The novel compound is stated to be cardioactive and may be made up with carriers into pharmaceutical compositions for oral administration.

    27.
    发明专利
    未知

    公开(公告)号：FI45184B

    公开(公告)日：1971-12-31

    申请号：FI145166

    申请日：1966-06-02

    Applicant: HOECHST AG

    Inventor： EHRHART G ,  LINDNER E ,  HAERTFELDER G ,  OTT H

    IPC: C07C217/62 ,  C07D213/38 ,  C07C91/16

    Abstract: Compounds of the general Formula (I) (wherein R1 represents a phenyl, methoxyphenyl or 2-pyridyl group, R2 represents a hydrogen atom or a methyl group and R3 and R4 each represent a C1- 4 alkyl group) and their acid addition salts are prepared by standard methods, e.g. reducing a compound of the Formula (II) (wherein R represents a hydrogen atom) or a salt thereof, or condensing a compound of the Formula (III) with a compound of the Formula (IV) (wherein X represents and reducing the product, optionally followed in either case by salt formation. The preparation of starting materials of Formulae (II) and (IV) is described. The compounds of the invention are useful in the treatment of hypertonia, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.

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