公开(公告)号：AU611676B2

公开(公告)日：1991-06-20

申请号：AU1328888

申请日：1988-03-18

Applicant: HOECHST AG

Inventor： RAGG HERMANN ,  PREIBISCH GERALD ,  HEIN FRIEDRICH ,  UHLMANN EUGEN ,  LINDENMAIER WERNER

IPC: G01N33/50 ,  A61K38/00 ,  A61K38/55 ,  C07K14/00 ,  C07K14/435 ,  C07K14/575 ,  C07K14/81 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  C07G17/00 ,  C07H21/04 ,  C07K3/28 ,  C07K13/00 ,  C12N5/00 ,  C12N9/64 ,  C12N15/00 ,  C12N15/15 ,  C12N15/62

Abstract: Human leuserpine-2 (hLS2) has the same gene structure as alpha -antitrypsin or angiotensinogen. By combination of exons from serpine genes which have this gene structure, recombinant genes can be produced which code for hybrid serpines. By expression of the recombinant genes in eukaryotic cells, the corresponding hybrid serpines can be obtained.

公开(公告)号：ZA881948B

公开(公告)日：1988-12-28

申请号：ZA881948

申请日：1988-03-18

Applicant: HOECHST AG

Inventor： RAGG HERMANN ,  HERMANN RAGG ,  PREIBISCH GERALD ,  GERALD PREIBISCH ,  HEIN FRIEDRICH ,  FRIEDRICH HEIN ,  UHLMANN EUGEN ,  EUGEN UHLMANN ,  LINDENMAIER WERNER ,  WERNER LINDENMAIER

IPC: G01N33/50 ,  A61K38/00 ,  A61K38/55 ,  C07K14/00 ,  C07K14/435 ,  C07K14/575 ,  C07K14/81 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  C12N ,  C12P ,  C07K ,  C07H ,  A61K ,  C12Q

Abstract: Human leuserpine-2 (hLS2) has the same gene structure as alpha -antitrypsin or angiotensinogen. By combination of exons from serpine genes which have this gene structure, recombinant genes can be produced which code for hybrid serpines. By expression of the recombinant genes in eukaryotic cells, the corresponding hybrid serpines can be obtained.

公开(公告)号：DK151788A

公开(公告)日：1988-09-21

申请号：DK151788

申请日：1988-03-18

Applicant: HOECHST AG

Inventor： RAGG HERMANN ,  PREIBISCH GERALD ,  HEIN FRIEDRICH ,  UHLMANN EUGEN ,  LINDENMAIER WERNER

IPC: G01N33/50 ,  A61K38/00 ,  A61K38/55 ,  C07K14/00 ,  C07K14/435 ,  C07K14/575 ,  C07K14/81 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  C07K15/04 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00 ,  C12P19/34

Abstract: Human leuserpine-2 (hLS2) has the same gene structure as alpha -antitrypsin or angiotensinogen. By combination of exons from serpine genes which have this gene structure, recombinant genes can be produced which code for hybrid serpines. By expression of the recombinant genes in eukaryotic cells, the corresponding hybrid serpines can be obtained.

公开(公告)号：PT87009A

公开(公告)日：1988-04-01

申请号：PT8700988

申请日：1988-03-18

Applicant: HOECHST AG

Inventor： RAGG HERMANN ,  PREIBISCH GERALD ,  HEIN FRIEDRICH ,  UHLMANN EUGEN ,  LINDENMAIER WERNER

IPC: G01N33/50 ,  A61K38/00 ,  A61K38/55 ,  C07K14/00 ,  C07K14/435 ,  C07K14/575 ,  C07K14/81 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  C12N15/00

Abstract: Human leuserpine-2 (hLS2) has the same gene structure as alpha -antitrypsin or angiotensinogen. By combination of exons from serpine genes which have this gene structure, recombinant genes can be produced which code for hybrid serpines. By expression of the recombinant genes in eukaryotic cells, the corresponding hybrid serpines can be obtained.