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    21.
    发明专利
    未知

    公开(公告)号：NO132432B

    公开(公告)日：1975-08-04

    申请号：NO157269

    申请日：1969-04-17

    Applicant: HOECHST AG

    Inventor： KOHL H ,  FRITSCH W ,  HAEDE W ,  RADSCHEIT K ,  STACHE U

    IPC: B01J25/02 ,  C07J19/00

    Abstract: 1275421 Cardioactive medicines FARBWERKE HOECHST AG 28 April 1969 [27 April 1968] 21595/69 Heading A5B [Also in Division C2] Pharmaceutical compositions comprise a carrier and a cardioactive steroid of formula: wherein R is the broken line indicates an optional 4, 5- double bond, and Y is oxo or a hydrogen atom with an α- or #-(hydroxy or C 1-6 acyloxy) group which may be α-oriented in the 4, 5 #-dihydro compounds only. Routes of administration are not specified. Reference has been directed by the Comptroller to Specification 1,184,238.

    23.
    发明专利
    未知

    公开(公告)号：FI48076B

    公开(公告)日：1974-02-28

    申请号：FI307971

    申请日：1971-10-28

    Applicant: HOECHST AG

    Inventor： HAEDE W ,  FRITSCH W ,  RADSCHEIT K ,  STACHE U

    IPC: C07J19/00 ,  C07C173/04

    Abstract: 1363293 14-Anhydrobufalin synthesis FARBWERKE HOECHST AG 29 Oct 1971 [30 Oct 1970] 50507/71 Heading C2U 3# - Hydroxy - 5# - bufa - 14,20,22 - trienolide (I) is prepared from 3-ethoxy-21,21-dimethoxypregna - 3,5,14 - trien - 20 - one (V) by the sequence: V # 3 - ethoxy - 20 - methylene- 21,21 - dimethoxy - pregna - 3,5,14 - triene # 3- oxo - 20 - methylenepregna - 4,14 - dien - 21 - al # 3,21 - dioxo - 23 - carboxychola - 4,14- dienic acid dimethyl ester # the free diacid # 3,21 - dioxochola - 4,14 - dienic acid # 3- oxo - bufa - 4,14,20 - trienolide (II) # 3 - oxo- 5# - bufa - 14,20 - dienolide (III) # 3 - oxo- 5# - bufa - 14,20,22 - trienolide (IV) #I. The invention comprises (a) the process sequence II # III # IV # I ; and (b) the process step IV # I when effected using trimethyl phosphite in isopropanol in the presence of H 2 IrCl 6 .

    24.
    发明专利
    未知

    公开(公告)号：SE364269B

    公开(公告)日：1974-02-18

    申请号：SE1375771

    申请日：1971-10-29

    Applicant: HOECHST AG

    Inventor： HAEDE W ,  FRITSCH W ,  RADSCHEIT K ,  STACHE U

    IPC: C07J19/00 ,  C07C173/04

    Abstract: 1363293 14-Anhydrobufalin synthesis FARBWERKE HOECHST AG 29 Oct 1971 [30 Oct 1970] 50507/71 Heading C2U 3# - Hydroxy - 5# - bufa - 14,20,22 - trienolide (I) is prepared from 3-ethoxy-21,21-dimethoxypregna - 3,5,14 - trien - 20 - one (V) by the sequence: V # 3 - ethoxy - 20 - methylene- 21,21 - dimethoxy - pregna - 3,5,14 - triene # 3- oxo - 20 - methylenepregna - 4,14 - dien - 21 - al # 3,21 - dioxo - 23 - carboxychola - 4,14- dienic acid dimethyl ester # the free diacid # 3,21 - dioxochola - 4,14 - dienic acid # 3- oxo - bufa - 4,14,20 - trienolide (II) # 3 - oxo- 5# - bufa - 14,20 - dienolide (III) # 3 - oxo- 5# - bufa - 14,20,22 - trienolide (IV) #I. The invention comprises (a) the process sequence II # III # IV # I ; and (b) the process step IV # I when effected using trimethyl phosphite in isopropanol in the presence of H 2 IrCl 6 .

    CARDIOACTIVE OXYDO-BUFADIENOLIDE AND PROCESS FOR PREPARING IT
    25.
    发明专利
    CARDIOACTIVE OXYDO-BUFADIENOLIDE AND PROCESS FOR PREPARING IT 未知

    公开(公告)号：CA929157A

    公开(公告)日：1973-06-26

    申请号：CA109542

    申请日：1971-04-05

    Applicant: HOECHST AG

    Inventor： STACHE U ,  LINDNER E ,  RADSCHEIT K ,  HAEDE W ,  FRITSCH W

    IPC: A61K31/70 ,  C07J71/00

    Abstract: 1315235 Bufapolyenolides FARBWERKE HOECHST AG 19 April 1971 [8 April 1970] 26359/71 Heading C2U The novel compound 3#-(α-L-rhamnopyranosyloxy) - 14,15# - epoxy - 14# - bufa - 4,20,22- trienolide is prepared from proscillaridin by successively acylating the three sugar hydroxy groups, dehydrating in the 14,15-position, adding hypohalous acid acoross the resulting # 14 - double bond, dehydrohalogenating the resulting 14#-hydroxy-15α-halo grouping, and lastly liberating the three sugar hydroxy groups by saponification. The novel compound is stated to be cardioactive and may be made up with carriers into pharmaceutical compositions for oral administration.

    26.
    发明专利
    未知

    公开(公告)号：DK126188B

    公开(公告)日：1973-06-18

    申请号：DK211469

    申请日：1969-04-17

    Applicant: HOECHST AG

    Inventor： RADSCHEIT K ,  STACHE U ,  FRITSCH W ,  HAEDE W

    IPC: A61K31/573 ,  A61K31/58 ,  C07C169/34

    Abstract: DELTA 14-20-KETO-21-DIALKOXY STEROIDS ARE PREPARED BY OXIDIZING 20-KETO-15 alpha ,21-DIHYDROXY STEROIDS OF THE GENERAL FORMULA IN WHICH Y is an oxo group which may be ketalized, GROUP WHICH MAY BE ETHERIFIED OR ESTERIFIED, A DELTA 3-, DELTA 2-, OR DELTA 3,5-ENOL ETHER GROUP OR A DELTA 3-, DELTA 2-, OR DELTA 3,5-ENAMINO GROUP, WHICH GROUPS MAY HAVE A DOUBLE BOND IN THE 4-POSITION, AND IS A LOWER ACYCLIC OR CYCLIC ACETAL GROUPING, ACETALIZING THE 15 alpha -HYDROXY-20-KETO-21-OXO STEROIDS OBTAINED, REACTING THE 15 alpha -HYDROXY-20-KETO-21-DIALKOXY STEROIDS THUS OBTAINED WITH SULFONIC ACID HALIDES AND TREATING THE 15-SULFONIC ACID ESTERS THUS OBTAINED WITH AGENTS SPLITTING OFF ACIDS. The products are valuable intermediates for the manufacture of medicaments.

    29.
    发明专利
    未知

    公开(公告)号：SE353534B

    公开(公告)日：1973-02-05

    申请号：SE534069

    申请日：1969-04-16

    Applicant: HOECHST AG

    Inventor： RADSCHEIT K ,  STACHE U ,  FRITSCH W ,  HAEDE W

    IPC: A61K31/573 ,  A61K31/58 ,  C07C169/00

    Abstract: DELTA 14-20-KETO-21-DIALKOXY STEROIDS ARE PREPARED BY OXIDIZING 20-KETO-15 alpha ,21-DIHYDROXY STEROIDS OF THE GENERAL FORMULA IN WHICH Y is an oxo group which may be ketalized, GROUP WHICH MAY BE ETHERIFIED OR ESTERIFIED, A DELTA 3-, DELTA 2-, OR DELTA 3,5-ENOL ETHER GROUP OR A DELTA 3-, DELTA 2-, OR DELTA 3,5-ENAMINO GROUP, WHICH GROUPS MAY HAVE A DOUBLE BOND IN THE 4-POSITION, AND IS A LOWER ACYCLIC OR CYCLIC ACETAL GROUPING, ACETALIZING THE 15 alpha -HYDROXY-20-KETO-21-OXO STEROIDS OBTAINED, REACTING THE 15 alpha -HYDROXY-20-KETO-21-DIALKOXY STEROIDS THUS OBTAINED WITH SULFONIC ACID HALIDES AND TREATING THE 15-SULFONIC ACID ESTERS THUS OBTAINED WITH AGENTS SPLITTING OFF ACIDS. The products are valuable intermediates for the manufacture of medicaments.

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