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    PROCESS FOR THE MANUFACTURIN OF ACYL DERIVATIVES
    21.
    发明专利
    PROCESS FOR THE MANUFACTURIN OF ACYL DERIVATIVES 未知

    公开(公告)号：YU295280A

    公开(公告)日：1983-06-30

    申请号：YU295280

    申请日：1980-11-20

    Applicant: HOFFMANN LA ROCHE

    Inventor： MONTAVON M ,  REINER R

    IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46

    Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.

    ACYL DERIVATIVES
    26.
    发明专利
    ACYL DERIVATIVES 未知

    公开(公告)号：ZA783030B

    公开(公告)日：1979-06-27

    申请号：ZA783030

    申请日：1978-05-26

    Applicant: HOFFMANN LA ROCHE

    Inventor： REINER R ,  MONTAVON M

    IPC: A61K31/545 ,  C07C59/00 ,  C07D501/36 ,  C07D501/60

    Abstract: The acyl derivatives provided by the present invention are compounds of the general formula (I) wherein R represents furyl, thienyl or phenyl optionally substituted by halogen, hydroxy, lower alkoxy or lower alkyl, R1 represents alkyl or aminocarbonylmethyl and X represents a group of the formula in which one of the two symbols R2 and R3 or R4 and R5 represents hydrogen and the other represents lower alkyl, carboxymethyl or sulphomethyl, and the pharmaceutically acceptable salts of said compounds and hydrates of said salts. Also disclosed are a process for the manufacture of the compounds and pharmaceutical preparations therefor. The compounds of the present invention have antibiotic activity, especially bactericidal activity.

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