公开(公告)号：US20110318748A1

公开(公告)日：2011-12-29

申请号：US13035177

申请日：2011-02-25

Applicant: John Davidson ,  Wolfgang Hinz ,  Jonathan Rothberg ,  Richard Whitaker

Inventor： John Davidson ,  Wolfgang Hinz ,  Jonathan Rothberg ,  Richard Whitaker

IPC: C12Q1/68

CPC classification number: C12N9/1252

Abstract: Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions.

Abstract translation: 提供了包含修饰的蛋白质，特别是具有改变的缓冲性质的经修饰的核酸结合蛋白质的方法，组合物，系统，装置和试剂盒。 例如，在一些实施方案中，描述了形成包含一个或多个氨基酸修饰以获得所需pKa值的修饰蛋白质的方法。 此外，本发明提供了在离子产生反应中使用这些修饰蛋白质的方法，例如基于离子的核酸测序反应。

公开(公告)号：US07922871B2

公开(公告)日：2011-04-12

申请号：US12669425

申请日：2009-01-19

Applicant: Roy Price ,  John Davidson

Inventor： Roy Price ,  John Davidson

IPC: C10B57/12

CPC classification number: B29B17/02 ,  B29B2017/0496 ,  B29K2105/06 ,  B29K2707/04 ,  B29L2009/00 ,  B29L2031/3085 ,  B29L2031/3091 ,  B29L2031/5245 ,  C10B7/06 ,  C10B53/07 ,  F27B9/045 ,  F27B9/40 ,  F27D7/06 ,  F27D17/001 ,  F27D19/00 ,  F27D2019/0031 ,  Y02P20/143 ,  Y02W30/622 ,  Y02W30/625

Abstract: A method of recycling composite material comprising carbon fibers and a resin, the method comprising: providing a furnace comprising at least a heating portion; providing a transporter for transporting the composite material through the furnace; loading the composite material on the transporter and transporting the composite material through the furnace; detecting a percentage of oxygen in an atmosphere in the heating portion when the composite material has entered this portion; and removing resin from the composite material, as it travels through the heating portion of the furnace on the transporter, by means of chemical decomposition at a first temperature, with the resultant generation of fumes; wherein the generated fumes are removed from the heating portion in a controlled manner, such that the percentage of oxygen in the atmosphere in the heating portion is controlled.

Abstract translation: 一种回收包含碳纤维和树脂的复合材料的方法，所述方法包括：提供至少包括加热部分的炉子; 提供用于运输复合材料通过炉子的运输机; 将复合材料装载在运输工具上并运输复合材料通过炉子; 当复合材料进入该部分时，检测加热部分的气氛中的氧气的百分比; 并且当复合材料在第一温度下通过化学分解行进通过运送器上的炉的加热部分时，从复合材料中除去树脂，从而产生烟雾; 其中以受控的方式将所产生的烟雾从加热部分移除，从而控制加热部分中的气氛中的氧的百分比。

公开(公告)号：US20100189629A1

公开(公告)日：2010-07-29

申请号：US12669425

申请日：2009-01-19

Applicant: Roy Price ,  John Davidson

Inventor： Roy Price ,  John Davidson

IPC: D01F9/12

CPC classification number: B29B17/02 ,  B29B2017/0496 ,  B29K2105/06 ,  B29K2707/04 ,  B29L2009/00 ,  B29L2031/3085 ,  B29L2031/3091 ,  B29L2031/5245 ,  C10B7/06 ,  C10B53/07 ,  F27B9/045 ,  F27B9/40 ,  F27D7/06 ,  F27D17/001 ,  F27D19/00 ,  F27D2019/0031 ,  Y02P20/143 ,  Y02W30/622 ,  Y02W30/625

Abstract: A method of recycling composite material comprising carbon fibres and a resin, the method comprising: providing a furnace comprising at least a heating portion; providing a transporter for transporting the composite material through the furnace; loading the composite material on the transporter and transporting the composite material through the furnace; detecting a percentage of oxygen in an atmosphere in the heating portion when the composite material has entered this portion; and removing resin from the composite material, as it travels through the heating portion of the furnace on the transporter, by means of chemical decomposition at a first temperature, with the resultant generation of fumes; wherein the generated fumes are removed from the heating portion in a controlled manner, such that the percentage of oxygen in the atmosphere in the heating portion is controlled.

Abstract translation: 一种回收包含碳纤维和树脂的复合材料的方法，所述方法包括：提供至少包括加热部分的炉子; 提供用于运输复合材料通过炉子的运输机; 将复合材料装载在运输工具上并运输复合材料通过炉子; 当复合材料进入该部分时，检测加热部分的气氛中的氧气的百分比; 并且当复合材料在第一温度下通过化学分解行进通过运送器上的炉的加热部分时，从复合材料中除去树脂，从而产生烟雾; 其中以受控的方式将所产生的烟雾从加热部分移除，从而控制加热部分中的气氛中的氧的百分比。

公开(公告)号：US20070000355A1

公开(公告)日：2007-01-04

申请号：US10580775

申请日：2004-02-17

Applicant: John Davidson

Inventor： John Davidson

IPC: B25B13/46 ,  B25B23/16 ,  B25G1/00

CPC classification number: B25B13/461 ,  B25B13/463 ,  B25B23/0035

Abstract: A ratchet wrench has a drive-stud element with a drive stud at a first end and a drive recess at a second end. The drive-stud element is coupled with a one-way drive transmitting wheel to rotate in unison therewith about an axis. The wrench can have a centering element that resists movement of the one-way drive transmitting wheel in at least one direction away from the axis. The drive-stud element and the one-way drive transmitting wheel can be separately formed. A method is also disclosed for operating a ratchet wrench with a drive-stud element with a drive stud at a first end and a drive recess at a second end.

Abstract translation: 棘轮扳手具有驱动螺柱元件，在第一端具有驱动螺柱，在第二端具有驱动凹部。 驱动螺柱元件与单向驱动传动轮联接以围绕轴线一致地旋转。 扳手可以具有抵抗单向驱动传动轮在远离轴线的至少一个方向上的运动的定心元件。 驱动单元元件和单向驱动传动轮可以单独形成。 还公开了一种用于操作棘轮扳手的方法，该棘轮扳手具有在第一端处具有驱动螺柱的驱动螺柱元件和在第二端处的驱动凹部。

公开(公告)号：US20060201289A1

公开(公告)日：2006-09-14

申请号：US11079010

申请日：2005-03-10

Applicant: John Davidson ,  George Charvat ,  C. Moon

Inventor： John Davidson ,  George Charvat ,  C. Moon

IPC: B25B23/16 ,  B25G1/00

CPC classification number: B25B23/0035

Abstract: Tools for detachably engaging a tool attachment are described that include a drive element and a mechanism for altering engagement forces between the tool attachment and the drive element. The mechanism includes a locking element and an actuating element coupled to the locking element.

Abstract translation: 描述了用于可拆卸地接合工具附件的工具，其包括用于改变工具附件和驱动元件之间的接合力的驱动元件和机构。 该机构包括锁定元件和联接到锁定元件的致动元件。

公开(公告)号：US06723051B2

公开(公告)日：2004-04-20

申请号：US09966368

申请日：2001-10-01

Applicant: John Davidson ,  Robert Mozayeni ,  Simon Fitall ,  Kevin Crutchfield

Inventor： John Davidson ,  Robert Mozayeni ,  Simon Fitall ,  Kevin Crutchfield

IPC: A61B802

CPC classification number: A61B5/02007 ,  A61B5/4076 ,  A61B5/411 ,  A61B5/7264 ,  A61B8/06 ,  A61B8/56 ,  G01S7/52036 ,  G01S15/8915 ,  G01S15/8979 ,  G06F19/00 ,  G06Q10/10 ,  G06Q50/22

Abstract: The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined manner. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. The present invention further provides an expert system for achieving the above.

Abstract translation: 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并以确定的方式分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 本发明还提供了一种用于实现上述的专家系统。