公开(公告)号：JP2012153617A

公开(公告)日：2012-08-16

申请号：JP2011011747

申请日：2011-01-24

Applicant: Kao Corp ,  花王株式会社

Inventor： KUMIHASHI KENTARO ,  SAKASAI MITSUYOSHI ,  KUSUOKU HIROSHI

IPC: A61K8/97 ,  A61K47/46 ,  A61Q11/00

Abstract: PROBLEM TO BE SOLVED: To provide a cold sense enhancing agent for enhancing cold sense induced by a cold sensing substance such as menthol, to provide a composition containing the cold sense enhancing agent, and to provide a cold sense enhancing method to use the cold sense enhancing agent.SOLUTION: There are provided the cold sense enhancing agent containing a Myrstica fragrans seed extract obtained from Myrstica fragrans seed by using water, a polar solvent, a nonpolar solvent or a mixture of two or more of the above solvents; the cold sensing substance-containing composition containing the cold sense enhancing agent; and a cold sense enhancing method to use the cold sense enhancing agent.

Abstract translation: 要解决的问题：提供一种用于增强由感温物质如薄荷醇引起的感冒的感冒增强剂，以提供含有感冒增强剂的组合物，并提供使用的冷感觉增强方法 冷感增强剂。 解决方案：通过使用水，极性溶剂，非极性溶剂或两种或更多种上述溶剂的混合物，提供了含有从黑曲霉（Myrstica fragrans）种子获得的燕麦种子提取物的冷感觉增强剂; 含有感温增强剂的含有感冒物质的组合物; 以及使用感冒增强剂的感冒增强方法。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2011256121A

公开(公告)日：2011-12-22

申请号：JP2010130245

申请日：2010-06-07

Applicant: Kao Corp ,  花王株式会社

Inventor： SAKASAI MITSUYOSHI ,  TAKATOKU HIROKO ,  KUMIHASHI KENTARO ,  SUZUKI YASUTO

IPC: A61K31/365 ,  A61K8/49 ,  A61P25/00 ,  A61P43/00 ,  A61Q90/00 ,  C07D307/88

Abstract: PROBLEM TO BE SOLVED: To provide an excellent potential-dependent cation channel inhibitor.SOLUTION: The potential-dependent cation channel inhibitor or masking agent uses, as effective component, a phthalide analog expressed by formula (1) [in the formula, X denotes -O-Y (wherein, Y denotes a 1 to 14C alkyl group or a 2 to 20C alkoxyalkyl group for which a hydrogen atom or a hydroxy group may substitute) or -NRR(wherein, Rand Rare each the same or different and denote a hydrogen atom or a 1 to 10C alkyl group)].

Abstract translation: 要解决的问题：提供优异的潜在依赖性阳离子通道抑制剂。 解决方案：电位依赖性阳离子通道抑制剂或掩蔽剂使用由式（1）表示的苯并呋喃类似物作为有效成分[在式中，X表示-OY（其中，Y表示1〜14C烷基 或氢原子或羟基可以被取代的2〜20℃的烷氧基烷基）或-NR 2 其中，R 1和R 2各自相同或不同，表示氢原子或1〜10个烷基） ]。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2011236169A

公开(公告)日：2011-11-24

申请号：JP2010110193

申请日：2010-05-12

Applicant: Kao Corp ,  花王株式会社

Inventor： TAKATOKU HIROKO ,  SAKASAI MITSUYOSHI ,  KUSUOKU HIROSHI ,  KUMIHASHI KENTARO

IPC: A61K36/23 ,  A61K36/53 ,  A61P43/00

Abstract: PROBLEM TO BE SOLVED: To provide an excellent inhibitor for a potential-dependent cation channel.SOLUTION: The inhibitor for a potential-dependent channel uses a plant selected from celery and basil or an extract thereof as an active ingredient.

Abstract translation: 要解决的问题：为潜在依赖性阳离子通道提供优异的抑制剂。 解决方案：用于潜在依赖性通道的抑制剂使用选自芹菜和罗勒的植物或其提取物作为活性成分。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2010000054A

公开(公告)日：2010-01-07

申请号：JP2008163169

申请日：2008-06-23

Applicant: Kao Corp ,  花王株式会社

Inventor： SAKASAI MITSUYOSHI

IPC: A23L27/10 ,  A61K8/97 ,  A61K36/18 ,  A61P1/10 ,  A61P1/14 ,  A61P9/00 ,  A61P11/14 ,  A61P29/02 ,  A61P31/04 ,  A61Q11/00 ,  C07C45/79 ,  C07C49/255

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing purified ginger oleoresins which are reduced in viscous components and coloring components, and improved in irritation. SOLUTION: The method for producing purified ginger oleoresin includes dispersing ginger oleoresin in 60-100 mass% of an organic solvent solution, and bringing the purified ginger oleoresin into contact with activated carbon which has a pore size distribution of 15-40 Å. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 待解决的问题：提供一种生产纯度较高的粘稠成分和着色成分的生姜油树脂的方法，提高了刺激性。 解决方案：生产纯化姜油树脂的方法包括将姜油树脂在60-100质量％有机溶剂溶液中分散，并将纯化姜油树脂与孔径分布为15-40埃的活性炭接触 。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2009167160A

公开(公告)日：2009-07-30

申请号：JP2008185813

申请日：2008-07-17

Applicant: Kao Corp ,  花王株式会社

Inventor： NAGASAWA AZUMI ,  MORIWAKI SHIGERU ,  SAKASAI MITSUYOSHI ,  MATSUOKA MEGUMI ,  SASAJIMA MICHIYO ,  ITO NORIKO

IPC: A61K36/23 ,  A61K8/97 ,  A61P1/16 ,  A61P3/10 ,  A61P9/10 ,  A61P11/06 ,  A61P15/00 ,  A61P17/06 ,  A61P17/14 ,  A61P21/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  A61Q7/00 ,  A61Q19/00

Abstract: PROBLEM TO BE SOLVED: To provide a novel external preparation, a hair restorer, an NFAT (nuclear factor of activated T cells) signal inhibitor, a calcineurin inhibitor, an NFAT signal inhibiting method, and a calcineurin activity inhibiting method. SOLUTION: The external preparation, the hair restorer, the NFAT signal inhibitor, and the calcineurin inhibitor comprise an extract obtained by previously washing Angelica atropurprea or the root of the plant with the use of an ethanol aqueous solution one to nine times, and thereafter extracting the ethanol washed plant or its root with the use of a 25-45 vol.% ethanol aqueous solution as an active ingredient. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供新颖的外用制剂，毛发修复剂，NFAT（活化T细胞的核因子）信号抑制剂，钙调神经磷酸酶抑制剂，NFAT信号抑制法和钙调神经磷酸酶活性抑制法。 解决方案：外用制剂，毛发恢复剂，NFAT信号抑制剂和钙调神经磷酸酶抑制剂包含通过使用乙醇水溶液预先洗涤当归阿托普兰或植物根而获得的提取物一至九次， 然后用25-45体积％的乙醇水溶液作为活性成分萃取乙醇洗涤的植物或其根部。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2007297372A

公开(公告)日：2007-11-15

申请号：JP2007051522

申请日：2007-03-01

Applicant: Kao Corp ,  花王株式会社

Inventor： TAKIZAWA MINORU ,  SATO MAYUMI ,  KUSUOKU HIROSHI ,  SAKASAI MITSUYOSHI

IPC: A61K36/896 ,  A23L1/30 ,  A61K8/49 ,  A61K8/97 ,  A61K31/522 ,  A61P3/04 ,  A61P43/00 ,  A61Q19/06

Abstract: PROBLEM TO BE SOLVED: To provide a lypolysis promoter, a slimming agent or a cellulite-ameliorating agent which can promote the decomposition of accumulated adipose tissues to show a slimming effect and therefore is effective for the reduction or prevention of obesity or the amelioration of inclination to stoutness.
SOLUTION: The lypolysis promoter comprises a plant Huang Hua Cai (a plant belonging to the genus Hemerocallis) or an extract from the plant and a xanthine derivative as active ingredients. Preferably, the lypolysis promoter comprises 1 pt.mass of the plant Huang Hua Cai (a plant belonging to the genus Hemerocallis) or the extract from the plant and 0.0001 to 10 pts.mass of a xanthine derivative as active ingredients.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供可以促进累积脂肪组织分解以显示减肥效果的溶纤酶促进剂，减肥剂或脂肪团改善剂，因此有效减少或预防肥胖或 改善对粗壮的倾向。 溶解促进剂包括植物黄花菜（属于萱草属的植物）或植物提取物和黄嘌呤衍生物作为活性成分。 优选地，溶解促进剂包含植物黄花菜（属于萱草属的植物）或植物提取物的1吨黄芩苷和作为活性成分的0.0001至10重量份的黄嘌呤衍生物。 版权所有（C）2008，JPO＆INPIT