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公开(公告)号：AU2011340221B2
公开(公告)日：2016-03-03
申请号：AU2011340221
申请日：2011-10-31
Applicant: KIMBERLY CLARK CO
Inventor： TOPOLKARAEV VASILY A , SCHOLL NEIL T , LEE JAEHONG , AMBROSE DIANNA L , KIM YOUNGSOOK
IPC: A01N25/02 , A01N65/00 , A01P1/00 , B29C48/305 , B29C48/92
Abstract: A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
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公开(公告)号：AU2012356251B2
公开(公告)日：2016-02-18
申请号：AU2012356251
申请日：2012-11-08
Applicant: KIMBERLY CLARK CO
Inventor： TOPOLKARAEV VASILY A , SCHOLL NEIL T , KIM YOUNGSOOK , KOENIG DAVID W , LEE JAEHONG
Abstract: The present invention relates to a wipe suitable for multiple re-use comprising a biopolymer matrix composition, said biopolymer matrix comprising from about 0.1% to about 40% of an essential oil, about 30% to about 95% of a biopolymer, and about 1% to about 50% of a carrier fluid wherein a limited amount of said essential oil can be released from said matrix composition when exposed to a liquid solution; and wherein an additional limited amount of said essential oil can be re-released repetitiously thereafter upon re-use with an additional exposure of a liquid solution to said wipe.
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公开(公告)号：MX2014007079A
公开(公告)日：2014-08-27
申请号：MX2014007079
申请日：2012-11-08
Applicant: KIMBERLY CLARK CO
Inventor： SCHOLL NEIL T , TOPOLKARAEV VASILY A , KIM YOUNGSOOK , KOENIG DAVID W , LEE JAE-HONG
Abstract: La presente invención se refiere a un paño adecuado para su reuso múltiple que comprende una composición de la matriz de biopolímero, la matriz de biopolímero que comprende de aproximadamente 0.1% a aproximadamente 40% de un aceite esencial, aproximadamente 30% a aproximadamente 95% de un biopolímero, y aproximadamente 1% a aproximadamente 50% de un fluido portador en donde una cantidad limitada de el aceite esencial puede liberarse de la composición de la matriz cuando se expone a una solución líquida; y en donde una cantidad limitada adicional de el aceite esencial puede volverse a liberar repetitivamente después de eso al volver a usarlo con una exposición adicional de una solución líquida a el paño.
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公开(公告)号：MX2013006451A
公开(公告)日：2013-06-28
申请号：MX2013006451
申请日：2011-10-26
Applicant: KIMBERLY CLARK CO
Inventor： WANG JAMES H , KOENIG DAVID W , TOPOLKARAEV VASILY A , KIM YOUNGSOOK , LEE JAEHONG , SCHOLL NEIL T
Abstract: Se proporciona una emulsión de aceite-en-agua que es ambientalmente amigable y que también exhibe actividad antimicrobial. Más específicamente, la fase de aceite de la emulsión incluye un aceite botánico derivado de una planta (por ejemplo timol, carvacrol, etc.). Debido a que el aceite botánico tiende a filtrarse afuera de la emulsión durante el almacenamiento y antes de que este sea usado en la aplicación deseada, un polímero dispersable en agua también es empleado en la fase acuosa de la emulsión para mejorar la estabilidad a largo plazo del aceite y, a su vez, la eficacia antimicrobial. Sin intentar el estar limitado por la teoría, se cree que el polímero dispersable en agua puede efectivamente encapsular el aceite botánico dentro de la emulsión e inhibir su liberación prematura. Una vez que la emulsión es formada, el agua puede entonces ser removida de manera que esta se haga un concentrado anhidro esencialmente. En esta manera, el polímero dispersable en agua no generalmente se surtirá antes del uso y prematuramente liberar el aceite botánico. Cuando se desea, la humedad puede simplemente ser aplicada de nuevo al concentrado para dispersar el polímero y activar la liberación del aceite botánico. Desde luego, para proporcionar el grado óptimo de biocompatibilidad, el polímero dispersable en agua también es un "biopolímero" que es biodegradable y/o renovable.
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公开(公告)号：AU2014407509B2
公开(公告)日：2020-09-03
申请号：AU2014407509
申请日：2014-09-30
Applicant: KIMBERLY CLARK CO
Inventor： KOENIG DAVID WILLIAM , ZAWADZKI MICHAEL ANDREW , UTTECHT CATHLEEN MAE , JOHNSON JEFFREY JANNE , MOLINE DAVID ANDREW , VONGSA REBECCA ANN , VANDEN HEUVEL AMY LYNN , KIM YOUNGSOOK , PARK SANGHA , ROGERS JESSICA CAROLINE
IPC: A61K9/08 , A61K9/06 , A61K31/185 , A61K31/194
Abstract: The present invention relates to prebiotic compositions and formulations comprising an α-hydroxy acid and salts thereof, such as lactic, glycolic, citric, tartaric or malic acid and a prebiotic agent, such as inulin, fructo-oligosaccharide (FOS), lactulose, galacto-oligosaccharide (GOS), raffinose, stachyose, isomalto-oligosaccharide, and xylo-oligosaccharide. Prebiotic compositions of the present invention provide a surprisingly synergist prebiotic effect and may be administered in several forms to a user, such as by application to a premoistened wiping substrate or dry bath tissue.
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Patent Agency Ranking
公开(公告)号：BR112013013814A2
公开(公告)日：2016-08-16
申请号：BR112013013814
申请日：2011-10-31
Applicant: KIMBERLY CLARK CO
Inventor： SHI BO , LEE JAEHONG , WANG JAMES H , SCHOLL NEIL T , TOPOLKARAEV VASILY A , KIM YOUNGSOOK
Abstract: processo para formação de uma composição antimicrobiana, composição antimicrobiana processada como massa em fusão, lenço e processo para remoção de bactérias a partir de uma superfície a presente invenção provê um processo para formação de uma composição, que inclui a misturação de um óleo botânico antimicrobianemente ativo (por exemplo, timol, carvacrol, etc.) e um polímero de amido modificado dentro de um dispositivo de combinação de massa em fusão (por exemplo, extrusora). de maneira diferente dos problemas associados com proteínas, o uso de polímeros de amido permite um maior grau de flexibilidade nas condições de processamento e é ainda capaz de alcançar boas propriedades na composição resultante. os presentes inventores constataram que pode ser empregado um plastificante para facilitar o processamento como massa em fusão do amido, assim como para intensificar a capacidade do óleo botânico escoar para a estrutura interna do amido, na qual ele pode ser retido de uma maneira estável. tipicamente, a composição, de maneira geral, também é livre de solventes. dessa maneira, o amido, de maneira geral, não irá sde dispersar antes do uso e liberar prematuramente o óleo botânico. entretanto, devido à sensibilidade à água do amido modificado, ele pode ser subsequentemente dispersado por umidade, quando for desejado para liberar o óleo botânico.
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公开(公告)号：ZA201303958B
公开(公告)日：2014-07-30
申请号：ZA201303958
申请日：2013-05-30
Applicant: KIMBERLY CLARK CO
Inventor： LEE JAEHONG , TOPOLKARAEV VASILY A , KOENIG DAVID WILLIAM , SCHOLL NEIL T , KIM YOUNGSOOK , WANG JAMES H
IPC: A01N20060101 , A01P20060101 , A47K20060101 , A47L20060101 , A61K20060101 , C09G20060101 , C11D20060101
Abstract: An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a “biopolymer” that is biodegradable and/or renewable.
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公开(公告)号：AU2011340216A1
公开(公告)日：2013-05-30
申请号：AU2011340216
申请日：2011-10-26
Applicant: KIMBERLY CLARK CO
Inventor： LEE JAEHONG , TOPOLKARAEV VASILY A , KOENIG DAVID W , SCHOLL NEIL T , KIM YOUNGSOOK , WANG JAMES H
Abstract: An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a "biopolymer" that is biodegradable and/or renewable.
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公开(公告)号：AU2011340221A1
公开(公告)日：2013-05-23
申请号：AU2011340221
申请日：2011-10-31
Applicant: KIMBERLY CLARK CO
Inventor： TOPOLKARAEV VASILY A , SCHOLL NEIL T , LEE JAEHONG , AMBROSE DIANNA L , KIM YOUNGSOOK
IPC: A01N25/02 , A01N65/00 , A01P1/00 , B29C48/305 , B29C48/92
Abstract: A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
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公开(公告)号：MX390246B
公开(公告)日：2025-03-20
申请号：MX2017003293
申请日：2017-03-13
Applicant: KIMBERLY CLARK CO
Inventor： VANDEN HEUVEL AMY LYNN , UTTECHT CATHLEEN MAE , MOLINE DAVID ANDREW , KOENIG DAVID WILLIAM , JOHNSON JEFFREY JANNE , ROGERS JESSICA CAROLINE , ZAWADZKI MICHAEL ANDREW , VONGSA REBECCA ANN , PARK SANGHA , KIM YOUNGSOOK
IPC: A61K31/733 , A61K9/06 , A61K9/08 , A61K9/70 , A61K31/185 , A61K31/191 , A61K31/194 , A61K31/702 , A61K45/06 , A61K47/26 , A61P1/00 , A61P17/00 , A61P43/00
Abstract: La presente invención se refiere a composiciones y formulaciones prebióticas que comprenden un a-hidroxiácido y sus sales, tales como ácido láctico, glicólico, cítrico, tartárico o málico y un agente prebiótico, tal como inulina, fructooligosacárido (FOS), lactulosa, galactooligosacárido (GOS), rafinosa, estaquiosa, isomaltooligosacárido, y xilooligosacárido. Las composiciones prebióticas de la presente invención proporcionan un efecto prebiótico sorprendentemente sinérgico y pueden administrarse de varias formas a un usuario, tales como por aplicación a un sustrato de limpieza prehumedecido o papel sanitario seco.
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