公开(公告)号：JP2009247230A

公开(公告)日：2009-10-29

申请号：JP2008096164

申请日：2008-04-02

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: C12Q1/68 ,  C12N15/09

Abstract: PROBLEM TO BE SOLVED: To provide a primer for detecting VKORC1 (1173C>T) and CYP2C9 (1075A>C) of single nucleotide polymorphism effective for prediction of individual difference in warfarin metabolic ability. SOLUTION: The VKORC1 (1173C>T) forward primer, the VKORC1 (1173C>T) reverse primer, the CYP2C9 (1075A>C) forward primer, and the CYP2C9 (1075A>C) reverse primer are the primers for detecting VKORC1 (1173C>T) in the base at the 1173 position when A of an initiation codon (ATG) of human VKORC1 gene is 1 position, wherein the base at the 3' terminus is a base G complementary to the base C at 1172 position of the VKORC1 gene, the base at the second position from the 3' terminus is a base corresponding to the base at 1173 position of the VKORC1 gene, and the base at the third position from the 3' terminus is a base T non-complementary to the base C at 1174 position of the VKORC1 gene. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于检测VKORC1（1173C> T）和CYP2C9（1075A> C）的单核苷酸多态性的引物，用于预测华法林代谢能力的个体差异。 解决方案：VKORC1（1173C> T）正向引物，VKORC1（1173C> T）反向引物，CYP2C9（1075A> C）正向引物和CYP2C9（1075A> C）反向引物是用于检测的引物 人类VKORC1基因的起始密码子（ATG）的A为1位时，碱基中的VKORC1（1173C> T）为1173位，其中3'末端的碱基为在1172位置与碱基C互补的碱基G 的VKORC1基因的第二位的碱基是与VKORC1基因的1173位的碱基相应的碱基，3'末端的第3位的碱基是非互补碱基 到VKORC1基因的1174位的碱基C。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2011004977A

公开(公告)日：2011-01-13

申请号：JP2009151476

申请日：2009-06-25

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU ,  KIMURA KAYU ,  KOSEKI HIROAKI ,  TOGAWA TAKESHI ,  FUKAZAWA HIROHIDE

IPC: A61M25/00

Abstract: PROBLEM TO BE SOLVED: To provide a catheter which can ameliorate the blocking of a through-hole by bio-tissue while retaining the effective size of the through-hole necessary for discharging and suction.SOLUTION: The catheter 1 is inserted into the bio-tissue of a mammal including a human being, and has a lumen 7 in the interior and a slender body 2 having at least one through-hole 6 communicating with the lumen 7. In the through-hole 6, the cross-sectional area in the direction vertical to the axis (a) of the through-hole 6 is unevenly formed, and a narrowest site A exists in the position other than the position where the depth from the surface of the body 2 is zero, and the brim of a site B nearer to the surface of the body 2 than to the narrowest site A in the through-hole 6 functions as a contact prevention portion which prevents the narrowest site A of the through-hole 6 from coming into direct contact with the bio-tissue.

Abstract translation: 要解决的问题：提供一种导管，其可以通过生物组织改善通孔的阻塞，同时保持排出和抽吸所需的通孔的有效尺寸。解决方案：导管1插入生物组织中， 包括人的哺乳动物的组织，并且在内部具有内腔7和细长体2，其具有与内腔7连通的至少一个通孔6.在通孔6中，截面积 与通孔6的轴线（a）垂直的方向不均匀地形成，并且在距离主体2的表面的深度为零的位置以外的位置处存在最窄的位置A，并且位置的边缘 B比通孔6中最狭窄的位置A更靠近主体2的表面的功能用作防止通孔6的最窄位置A与生物组织直接接触的接触防止部分。

公开(公告)号：JP2010273989A

公开(公告)日：2010-12-09

申请号：JP2009131367

申请日：2009-05-29

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KOSEKI HIROAKI ,  FUKAZAWA HIROHIDE ,  KIMURA KAYU ,  KIYOHARA MASANOBU ,  TOGAWA TAKESHI

IPC: A61M5/00

Abstract: PROBLEM TO BE SOLVED: To provide a medicine administration device, heightening the workability of installing a catheter in a living body before a fluid such as a medicine is discharged into the living body. SOLUTION: This medicine administration device includes: the catheter 2 which is an elongated tubular skeleton having an internal channel and has a first fluid intake port 3 for taking a fluid into the internal channel, a second fluid intake port 4 for taking the liquid into the internal channel, and at least one through hole 7 located between the first fluid intake port 3 and the second fluid intake port 4 in the side surface of the tubular skeleton and communicating the internal channel with the outside; a pump A communicated with the first fluid intake port 3; a pump B communicated with the second fluid intake port 4; and a control part 5 for controlling the drive of the pumps A, B. The control part 5 has a first operation mode of delivering saline from the pump A to the pump B through the interior of the internal channel of the catheter 2. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供一种药剂管理装置，在将诸如药物的流体排出到生物体之前，提高将活体中的导管安装在生物体中的可操作性。 解决方案：该药剂管理装置包括：导管2，其是具有内部通道的细长管状骨架，并具有用于将流体引入内部通道的第一流体吸入口3， 液体进入内部通道，以及位于管状骨架侧表面中的位于第一流体进入口3和第二流体进入口4之间的至少一个通孔7，并将内部通道与外部连通; 与第一流体吸入口3连通的泵A; 与第二流体吸入口4连通的泵B; 以及用于控制泵A，B的驱动的控制部分5.控制部件5具有通过导管2的内部通道的内部将盐水从泵A输送到泵B.第一操作模式。

版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010082262A

公开(公告)日：2010-04-15

申请号：JP2008255561

申请日：2008-09-30

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KOSEKI HIROAKI ,  KIMURA KAYU ,  KIYOHARA MASANOBU

IPC: A61M25/02

Abstract: PROBLEM TO BE SOLVED: To provide a catheter which can be directly fixed to not only a hollow organ which has a space inside, such as stomach and intestine, but also a non-hollow organ which has no space inside, such as liver and kidney. SOLUTION: The catheter 1, used for mammals including humans, is provided with a long and thin conduit 2 which has an opening at its end and a fixing part 3 forming a flange which is arranged near the end of the conduit 2 and is fixed to the outer surface of an organ 101 of the mammal. The fixing part 3 is provided with through-holes 4, and the organ 101 and the fixing part 3 are fixed by suture thread 4a through the through-holes 4. As a result, the catheter 1 is fixed to the organ 101. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种导管，其不仅可以直接固定在内部具有空间的中空器官，例如胃和肠，而且还可以是内部没有空间的非中空器官，例如 肝肾。 解决方案：用于包括人类的哺乳动物的导管1设置有长而薄的导管2，其在其端部具有开口，并且固定部分3形成布置在导管2的端部附近的凸缘， 固定在哺乳动物的器官101的外表面。 固定部3设置有通孔4，通过通孔4将缝合线4a固定在器官101和固定部3上。结果，导管1被固定在器官101上。

版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2009285344A

公开(公告)日：2009-12-10

申请号：JP2008143585

申请日：2008-05-30

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： MURAKI KAYU ,  KIYOHARA MASANOBU ,  KOSEKI HIROAKI

IPC: A61M5/00 ,  A61D7/00

Abstract: PROBLEM TO BE SOLVED: To properly and stably administer a medicine including a multi-medicine combined use to mammals. SOLUTION: This medicine administrating apparatus 1 for mammals is embedded in or loaded on a dog 3, and administrates medicines to the dog 3. The medicine administrating apparatus 1 includes a plurality of medicine tanks 10a to 10c which each contains a plurality of kinds of medicines to be administrated to the dog 3, and a plurality of conduits 13a to 13c which are installed in each of the plurality of the medicine tanks 10a to 10c for introducing the contained medicines into the body from each of the plurality of the medicine tanks 10a to 10c. The medicine administrating apparatus 1 also includes pumps 12a to 12c which drive a medicine contained in each of the plurality of the medicine tanks 10a to 10c toward each of the plurality of the conduits 13a to 13c, and a control section C which controls the administration of a plurality of medicines to the dog 3. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：适当和稳定地将包括哺乳动物的多药联合用药物。 解决方案：将哺乳动物的药剂管理装置1嵌入或装载在狗3上，向狗3施用药剂。药剂管理装置1包括多个药液容器10a〜10c， 向狗3施用的药物种类，以及多个管道13a〜13c，其安装在多个药液容器10a〜10c的每一个中，用于将所含的药物从多种药物中的每一种引入体内 罐10a至10c。 药剂管理装置1还包括将多个药液容器10a〜10c各自容纳的药物朝向多个导管13a〜13c中的每一个驱动的泵12a〜12c，以及控制部C 多种药物给狗3.版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2008134189A

公开(公告)日：2008-06-12

申请号：JP2006321948

申请日：2006-11-29

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： KIYOHARA MASANOBU

IPC: G01N33/53 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a probe solidifying reaction array capable of determining the liquid leakage state between sections and guaranteeing the integrity of each inspection result.
SOLUTION: This array can detect the liquid leakage by spotting a probe also in a region where a partition for partitioning each section comes into contact with a bio-chip and by using the probe as a liquid leakage detection probe. The probe solidifying reaction array comprises a channel formed of a substrate and a section partitioning base material, a detection probe solidified to the channel on the substrate, and the liquid leakage detection probe fixed to the adhesion surface of the substrate on the substrate with the section partitioning base material.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供能够确定各部分之间的液体泄漏状态并确保每个检查结果的完整性的探针凝固反应阵列。 解决方案：该阵列还可以在用于分隔每个部分的分隔件与生物芯片接触的区域中并且通过使用探针作为液体泄漏检测探针来检测探针来检测液体泄漏。 探针固化反应阵列包括由基板形成的通道和部分分隔基材，固化到基板上的通道的检测探针，以及固定到基板上的基板的粘合表面上的液体泄漏检测探针， 分割基材。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2004191253A

公开(公告)日：2004-07-08

申请号：JP2002361165

申请日：2002-12-12

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： OHASHI YOKO ,  SHINOHARA ETSUO ,  KIYOHARA MASANOBU

IPC: G01N33/53 ,  C07K17/00 ,  C12N15/09 ,  G01N33/566 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a probe solid phase reaction array excellent in reaction efficiency and reproducibility and enabling visually easy confirmation. SOLUTION: In the probe solid phase reaction array wherein probes are converted to a solid phase on a support, the support is internally equipped with the first - n-th reaction parts (wherein n is an integer of 2 or more) and the probes are grouped corresponding to the first - n-th reaction parts to be arranged. The fixing positions of the probes in the respective reaction parts are the same positions of the respective reaction parts so that the probes are positioned on one or more lines present at the same distance from the terminals of the respective reaction parts. COPYRIGHT: (C)2004,JPO&NCIPI

Abstract translation: 要解决的问题：提供反应效率和再现性优异的视觉上容易确认的探针固相反应阵列。 解决方案：在其中探针在载体上转化为固相的探针固相反应阵列中，载体内部配备有第n-n个反应部分（其中n为2以上的整数）和 对应于要布置的第n-n个反应部件对探针进行分组。 各反应部中的探针的固定位置与各反应部的位置相同，使得探针位于与各反应部的端子相同距离的一条或多条线上。 版权所有（C）2004，JPO＆NCIPI