公开(公告)号：JP2005130722A

公开(公告)日：2005-05-26

申请号：JP2003367392

申请日：2003-10-28

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： NAGAOKA TOMONORI ,  ITO TOMOKO ,  HORII TOSHINOBU

IPC: C12N15/09 ,  C12M1/00 ,  C12Q1/68 ,  C12R1/445

Abstract: PROBLEM TO BE SOLVED: To provide a method for analyzing the genotype of a staphylococcus, by which the arrangement and mutation of the gene group of a clinically important genus staphylococcus can rapidly and quickly be analyzed, to provide a probe capable of being suitably used, when the genotype of a staphylococcus is used, to provide a microarray, and to provide a method for preparing a sample for hybridization. SOLUTION: A probe group each containing a specific base sequence and used for specifying the genotype of the staphylococcus. A microarray loaded with the probes. The probe or microarray is used to identify the genotype of the staphylococcus. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 待解决的问题：提供一种用于分析葡萄球菌基因型的方法，通过该方法可以快速，快速地分析临床上重要的葡萄球菌基因组的排列和突变，以提供能够被 当使用葡萄球菌的基因型时，适当使用提供微阵列，并提供制备用于杂交的样品的方法。 解决方案：每个含有特定碱基序列并用于指定葡萄球菌基因型的探针组。 装有探针的微阵列。 探针或微阵列用于鉴定葡萄球菌的基因型。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2011185705A

公开(公告)日：2011-09-22

申请号：JP2010050491

申请日：2010-03-08

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： NAGAOKA TOMONORI ,  KONNO JUNSUKE

IPC: G01N35/04

Abstract: PROBLEM TO BE SOLVED: To rightly treat all of biosamples by certainly preventing the mistake of the installation position of a container in the case where a plurality of containers, which house the biosamples, are treated at the same time.
SOLUTION: The biomolecule separator 1 is equipped with: a plurality of separation container support parts 5 for supporting the separation containers for housing the biosamples, a number-of-container input means for permitting the input of the number of the separation containers supported on the separation container support part 5; a separation position indication means 12 for indicating the separation container support part 5, which is arranged at the position corresponding to the number of the separation containers inputted by the number-of-container input means, of a plurality of the separation container support parts 5 on an operator; and a treatment means 6 for applying treatment for separating target biomolecules to the biosamples in the separation containers supported on the separation container support parts 5 indicated by the separation position indication means 12.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：在容纳生物样品的多个容器同时处理的情况下，通过肯定地防止容器的安装位置的错误来正确地处理所有生物样品。 解决方案：生物分子分离器1配备有：用于支撑用于容纳生物样品的分离容器的多个分离容器支撑部件5，用于允许输入数量的分离容器的多个容器输入装置 支撑在分离容器支撑部5上; 用于指示分离容器支撑部分5的分离位置指示装置12，该分离容器支撑部分5布置在与由容器数量输入装置输入的分离容器的数量相对应的位置处的多个分离容器支撑部分5 在操作员身上 以及处理装置6，用于将分离目标生物分子的处理用于分离容器支撑部分5中支撑的分离容器中的生物样品的分离位置指示装置12。（C）2011，JPO和INPIT

公开(公告)号：JP2007014266A

公开(公告)日：2007-01-25

申请号：JP2005199068

申请日：2005-07-07

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： NAGAOKA TOMONORI

IPC: C12N15/09 ,  C12Q1/68

Abstract: PROBLEM TO BE SOLVED: To provide a gene detection method using a normalized orthogonal sequence having improved quantitative determination accuracy. SOLUTION: The method for converting to a normalized orthogonal sequence specific to a base-substitution type of a target nucleic acid is composed of a step to anneal the target nucleic acid with an upstream primer having a normalized orthogonal sequence and a sequence region complementary to the target nucleic acid, having a normalized orthogonal sequence at the 5' terminal and a sequence complementary to the base substitution part on the 3' terminal, a step to extend the complementary chain of the target nucleic acid from the upstream primer, a step to modify the extended complementary chain to a single-stranded nucleic acid, a step to anneal the single-stranded nucleic acid with a downstream primer constituting a part of the target nucleic acid and having a downstream sequence of the region hybridizing the upstream primer, and a step to extend the complementary chain of the normalized orthogonal sequence from the downstream primer. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供使用具有改进的定量确定精度的归一化正交序列的基因检测方法。 解决方案：用于转换为靶核酸的碱基取代型特异性的归一化正交序列的方法包括使靶核酸与具有归一化正交序列和序列区的上游引物退火的步骤 与目标核酸互补，在5'末端具有归一化的正交序列和与3'末端上的碱基取代部分互补的序列，扩增来自上游引物的靶核酸的互补链的步骤， 将扩增的互补链修饰为单链核酸的步骤，将构建一部分靶核酸的下游引物与单链核酸退火并具有与上游引物杂交的区域的下游序列的步骤， 以及从下游引物扩展归一化正交序列的互补链的步骤。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006141343A

公开(公告)日：2006-06-08

申请号：JP2004339091

申请日：2004-11-24

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： NAGAOKA TOMONORI ,  SAKAMOTO MICHIKO

IPC: C12N5/10 ,  A01K67/027 ,  A61K38/16 ,  A61K48/00 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68

Abstract: PROBLEM TO BE SOLVED: To provide a new DDS (drug delivery system) capable of continuously producing a peptide, a protein, a physiologically active substance useful for a living body, required to be fixed in the body for a long period, and capable of being maintained for the long period. SOLUTION: A symbiotic or parasitic organism is provided based on a result of an assiduous study in which a gene recombinant is prepared by introducing a foreign gene useful for a host into an organism species having ability of symbiotically or parasitically living with the host, then the gene recombinant is made to symbiotically or parasitically live with the host, and therefore a gene product of the gene is expressed in a cell of the host for the long period, wherein the parasitic organism comprises the gene recombinant containing the foreign gene, so that the foreign gene which expresses the gene product in the host is incorporated into the gene recombinant. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供能够连续生产长期固定在体内的肽，蛋白质，可用于生物体的生理活性物质的新型DDS（药物递送系统） 并能够长期维持。 解决方案：基于进行研究的结果提供了共生或寄生生物，其中通过将可用于宿主的外源基因引入具有与宿主共生或寄生的能力的生物体中来制备基因重组体 然后使基因重组体与宿主共生或寄生生活，因此该基因的基因产物长期在宿主的细胞中表达，其中寄生生物体包含含外来基因的基因重组体， 使得在宿主中表达基因产物的外源基因并入重组基因。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2006029953A

公开(公告)日：2006-02-02

申请号：JP2004208660

申请日：2004-07-15

Applicant: Olympus Corp ,  オリンパス株式会社

Inventor： ITO TOMOKO ,  NAGAOKA TOMONORI ,  FUKUOKA TAKAHISA

IPC: G01N33/53 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/78 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a solidification carrier for living body-related substance detection, a probe solidification method, and a living body-related substance analysis method, for efficiently analyzing living body-related substances in a specimen with high reliability.
SOLUTION: As to this solidification carrier for living body-related substance detection, a plurality of probes for detecting living body-related substances are solidified at the same address and a ratio at which the substances are solidified is known. The probe solidification method comprises a first step for preparing a plurality of probes for detecting one or more living body-related substances, a second step for mixing the plurality of probes to obtain a mixed probe, and a third step for bringing the mixed probe into contact with the same address of the carrier. The ratio of the plurality of probes is measured between the first and second steps, or between the second and third steps, or after the third step. The living body-related substance analysis method uses the solidification carrier.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种用于生物体相关物质检测的固化载体，探针固化方法和与活体相关的物质分析方法，用于有效地分析具有高可靠性的样品中的活体相关物质 。 解决方案：对于这种生物体相关物质检测用凝固载体，多个用于检测活体相关物质的探针以相同的地址固化，并且物质固化的比例是已知的。 探针凝固法包括：制备用于检测一种或多种生物体相关物质的多个探针的第一步骤，用于混合多个探针以获得混合探针的第二步骤，以及将混合探针置于 与承运人的地址相同。 在第一步骤和第二步骤之间或在第二步骤和第三步骤之间或在第三步骤之后测量多个探针的比率。 生物体相关物质分析方法使用凝固载体。 版权所有（C）2006，JPO＆NCIPI