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    23.
    发明专利
    未知

    公开(公告)号：FR2726762A1

    公开(公告)日：1996-05-15

    申请号：FR9413564

    申请日：1994-11-10

    Applicant: OREAL

    Inventor： RIBIER ALAIN ,  BIATRY BRUNO

    IPC: A61K47/16 ,  A61K8/02 ,  A61K8/04 ,  A61K8/06 ,  A61K8/34 ,  A61K8/42 ,  A61K8/68 ,  A61K9/127 ,  A61Q19/00 ,  A61Q19/08 ,  B01J13/00 ,  C07C31/22 ,  C07C271/12 ,  A61K9/10 ,  A61K7/48

    Abstract: Dispersions comprise 60-98% of aq. phase in which 2-40% of an oily phase is dispersed and stabilised by particles of cubic gel formed from: (i) 0.1-15 wt. % 3,7,11,15-tetramethyl- 1,2,3-hexadecanetriol or phytantriol, N-2-alkoxycarbonyl derivs. of N-methyl glucamine or unsatd. fatty acid monoglycerides; and (ii) 0.05-3 wt.% of a dispersing and stabilising agent (II) which is a water soluble surfactant at room temp. contg. an aliphatic opt. satd. 8-22C chain. The oily phase is pref. in the form of droplets of 0.1-10 mu m. The cpd. in step (i) is present in a relative wt. ratio of 0.02-1/1 (pref. 0.05-0.5/1) cf. the oily phase and 2-200 cf. (II). N-2-Alkoxycarbonyl N-methyl glucamine derivs. are of formula (I), pref. N-2-hexyldecyl, N-2-ethylhexyl or N-butyloctyl- oxycarbonyl-N-methyl-glucamine. RO-CO-N(CH3)-CH2-(CHOH)4-CH2OH (I) R = branched 6-18C alkyl. The cubic gel may contain a mixt. of 10-30 wt.% phytantriol and 70-90 wt.% of at least one N-methylglucamine N-2-alkoxycarbonyl, as well as a hydrophilic and/or a lipophilic active ingredient. The unsatd. fatty acid may be 50-99 (pref. 70-90) wt.% glyceryl monooleate or monolineate, present in a mixt. with 1-50 (pref. 10-30) wt.% phytantriol.

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