公开(公告)号：JP2009002876A

公开(公告)日：2009-01-08

申请号：JP2007165802

申请日：2007-06-25

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： TAKAHASHI MAKOTO ,  NAKATANI MASAYA ,  USHIO KOJI

IPC: G01N27/416 ,  G01N27/28 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To facilitate the suppression and removal of air bubbles, and to raise the reliability related to the measurement of a cell electrophysiology sensor. SOLUTION: The cell electrophysiology sensor includes a diaphragm 2 having at least one through hole 1, and a frame 3 that supports this diaphragm 2 and has a cavity 4. Since the shape of an end 5 of the frame 3 is made to have different heights, and the occurrence of air bubbles can be suppressed and the removal of the remaining air bubbles is facilitated. Therefore, the reliability in the measurement by the cell electrophysiology sensor can be raised. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：为了促进气泡的抑制和去除，并且提高与细胞电生理学传感器的测量相关的可靠性。 解决方案：细胞电生理学传感器包括具有至少一个通孔1的隔膜2和支撑该隔膜2并具有空腔4的框架3.由于框架3的端部5的形状被制成 具有不同的高度，并且可以抑制气泡的发生，并且便于除去剩余的气泡。 因此，可以提高细胞电生理学传感器的测量的可靠性。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2008304304A

公开(公告)日：2008-12-18

申请号：JP2007151404

申请日：2007-06-07

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： NAKATANI MASAYA ,  USHIO KOJI ,  HIRAOKA SOICHIRO ,  OSHIMA AKIYOSHI ,  TAKAHASHI MAKOTO

IPC: G01N27/28 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To solve the problem that, as conventionally a micropipette is attached to an electrode holder with a screw and an O ring to ensure airtightness, such a method makes the work complicated and reduces the measurement efficiency. SOLUTION: The microprobe includes: a micropipette 10; a socket 7 having a first opening part 8 and a second opening part 9; a measuring electrode 4; a sleeve 2; and a connection member 3 provided with a pressure connection port 5, wherein, the back end of the micropipette 10 is inserted into the first opening part 8 of the socket 7, and the sleeve 2 is inserted into the second opening part 9 of this socket 7. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 解决的问题为了解决这样一个问题，像以往那样将微量移液器安装在具有螺钉和O形环的电极座上以确保气密性，这种方法使工作变得复杂并且降低了测量效率。 解决方案：微探针包括：微量移液管10; 具有第一开口部8和第二开口部9的插座7; 测量电极4; 套筒2; 以及设置有压力连接口5的连接部件3，其中，微量吸管10的后端插入到插座7的第一开口部分8中，套筒2插入该插座的第二开口部分9中 7.版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2011112594A

公开(公告)日：2011-06-09

申请号：JP2009271379

申请日：2009-11-30

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： YAMAMOTO KENJU ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO ,  HIRAOKA SOICHIRO

IPC: G01N27/28 ,  C12M1/34 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To provide a sensor chip for securely adsorbing or trapping a spherical substance, such as a particle or a cell, and also to provide a sensor device using the same. SOLUTION: The sensor chip is equipped with a sheet and a frame body to support the periphery of the sheet, in which the sheet has at least a through-hole to penetrate a first surface and a second surface facing the first surface and a recess continuously provided from the through-hole has a diameter greater than the bore diameter of the through-hole and a narrow-down portion on the first surface side. The structure provides a sensor chip improving the adhesiveness between the spherical substance, such as an particle and a cell, and the recess. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供用于可靠地吸附或捕获诸如颗粒或电池的球形物质的传感器芯片，并且还提供使用该传感器芯片的传感器装置。 解决方案：传感器芯片配备有片材和框架体，以支撑片材的周边，其中片材具有至少一个通孔以穿透第一表面和面向第一表面的第二表面， 从通孔连续设置的凹部的直径大于通孔的孔径和第一表面侧的缩小部分。 该结构提供了改善诸如颗粒和电池的球形物质与凹部之间的粘合性的传感器芯片。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010223655A

公开(公告)日：2010-10-07

申请号：JP2009069471

申请日：2009-03-23

Applicant: PANASONIC CORP

Inventor： OSHIMA AKIYOSHI ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO

IPC: G01N33/543 ,  C12M1/00 ,  G01N33/553

Abstract: PROBLEM TO BE SOLVED: To provide a sensor enhanced in sensitivity. SOLUTION: The sensor includes a base material 5, the vapor deposition layer 6 comprising a plurality of the particles 8 accumulated on the base material 5 in a branched state to be integrally bonded to each other and a plurality of the functional molecules 7 joined to the surfaces of the particles 8 of the vapor deposition layer 6, and the surfaces of the respective particles 8 contains aluminum oxide as the main component. By this constitution, the surface area of the base material 5 is magnified and the functional molecules 7 can be fixed in high density. As a result, the sensitivity of the sensor is enhanced. COPYRIGHT: (C)2011,JPO&INPIT

公开(公告)号：JP2009168794A

公开(公告)日：2009-07-30

申请号：JP2008194473

申请日：2008-07-29

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： USHIO KOJI ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO

IPC: G01N27/28 ,  C12M1/42

CPC classification number: G01N33/48728

Abstract: PROBLEM TO BE SOLVED: To aim at manufacturing of a cellular electrophysiological sensor with high measurement precision.
SOLUTION: In order to achieve the purpose, following processes are included in the present invention: the process of holding sensor chips 14; the process of holding glass tubes 13 enclosing the outer circumference of the lateral surface of the sensor chips 14; and the process of melting the glass tubes 13 to glass-deposit with the lateral surface of the sensor chip 14, while giving wind pressure towards the lateral surface of the glass tube 13 from outside of the glass tube 13. Thereby, the present invention allows to encircle the outer circumference of the sensor chips 14 with the glass tube 13 of high hydrophilicity, resulted in possible manufacturing of cellular electrophysiological sensor with high measurement precision.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：针对制造具有高测量精度的细胞电生理传感器。 解决方案：为了实现该目的，本发明包括以下处理：保持传感器芯片14的过程; 保持包围传感器芯片14的侧表面的外周的玻璃管13的过程; 以及熔融玻璃管13以与传感器芯片14的侧表面玻璃沉积的过程，同时从玻璃管13的外部向玻璃管13的侧表面施加风压。由此，本发明允许 以高亲水性的玻璃管13环绕传感器芯片14的外周，导致可能制造具有高测量精度的细胞电生理传感器。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009072130A

公开(公告)日：2009-04-09

申请号：JP2007244828

申请日：2007-09-21

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： USHIO KOJI ,  NAKATANI MASAYA ,  TAKAHASHI MAKOTO

IPC: C12M1/34 ,  G01N27/28 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To improve the measuring precision of a cellular electrophysiological sensor. SOLUTION: This device for the cellular electrophysiological sensor is equipped with a holding plate 11, a storage vessel 12 installed above the holding plate 11, a flow passage 13 installed below the holding plate 11, a tubular chip-holding part 15 inserted into the perforation 14 of the holding plate 11 and a sensor chip 16 inserted into the lower end of the chip-holding part 15, and the sensor chip 16 has a cell-holding plate 17 formed with a conductive hole 20. The lower surface 17A of the cell-holding plate is positioned below the lower surface 11A of the holding plate. Thereby, the sensor can flow bubbles off by the flow of liquid even if the bubbles attach in the vicinity of the conductive hole 20 on the side of the flow passage 13, and as a result, the measuring precision of the cellular electrophysiological sensor is improved. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提高细胞电生理传感器的测量精度。 解决方案：用于细胞电生理传感器的装置配备有保持板11，安装在保持板11上方的储存容器12，安装在保持板11下方的流动通道13，插入的管状芯片保持部15 进入保持板11的穿孔14和插入芯片保持部15的下端的传感器芯片16，并且传感器芯片16具有形成有导电孔20的电池保持板17.下表面17A 位于保持板的下表面11A的下方。 因此，即使气泡附着在流路13一侧的导电孔20附近，传感器也能够通过液体流动气泡，结果提高了细胞电生理传感器的测定精度 。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009058461A

公开(公告)日：2009-03-19

申请号：JP2007227734

申请日：2007-09-03

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： NAKATANI MASAYA ,  USHIO KOJI ,  HIRAOKA SOICHIRO ,  OSHIMA AKIYOSHI ,  TAKAHASHI MAKOTO

IPC: G01N1/00 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide a dispensing apparatus capable of dispensing prescribed liquid and solid components while extracting/moving the solid component into other liquid in approximate synchronism with its dispensing operation.
SOLUTION: The dispensing apparatus is composed of a component separating section and a pipette section 11. The component separating section includes an introducing channel 7 for introducing a first solution 6 containing solid particles 4, a flow channel 2 for introducing a second solution 9, concentration gradient generating means 3 for generating a concentration gradient of the solid particles 4 in the middle portion of the flow channel 2, and a lead-out channel 8 for leading out the first solution 6. The pipette section 11 is disposed so as to communicate with an end of the flow channel 2 from which the second solution 9 containing separated solid particles 4 moved from the first solution 6 into the second solution 9 by the concentration gradient generating means 3 is discharged.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种能够在与其分配操作大致同步地提取/移动固体组分到其它液体的同时分配规定的液体和固体组分的分配装置。 分配装置由分离部分和移液管部分11组成。部件分离部分包括用于引入含有固体颗粒4的第一溶液6的引入通道7，用于引入第二溶液的流动通道2 如图9所示，用于产生固体颗粒4在流动通道2的中间部分的浓度梯度的浓度梯度产生装置3以及用于引出第一溶液6的引出通道8.移液管部分11设置成 与通过浓度梯度发生装置3将分离的固体颗粒4从第一溶液6移动到第二溶液9的第二溶液9从该流路2的一端排出。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2008306968A

公开(公告)日：2008-12-25

申请号：JP2007157213

申请日：2007-06-14

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： USHIO KOJI ,  NAKATANI MASAYA ,  HIRAOKA SOICHIRO ,  OSHIMA AKIYOSHI ,  TAKAHASHI MAKOTO

IPC: C12M1/34 ,  G01N27/28 ,  G01N27/327

Abstract: PROBLEM TO BE SOLVED: To improve the measuring accuracy of a cell electrophysiological sensor. SOLUTION: A device for the cell electrophysiological sensor is equipped with a cell-holing chip 11 and a substrate 9 for covering the sides of the cell-holding chip 11 so as to attain the objectives. Furthermore, the cell-holing chip 11 is provided with a conducting hole 14 connecting the upper and the lower surfaces thereof. The cell-holding chip 11 comprises silicon as the principal component. The substrate 9 is formed of glass and a hydrophilic film 16, composed of at least either silicon oxide or silicon nitride, is formed on each side of the cell-holing chip 11. The substrate 9 is heat-fused to the hydrophilic film 16. Thus, gaps between the sides of the cell-holding chip 11 and the substrate 9 can be reduced to raise airtightness and as a result, improve the measurement accuracy of the cell electrophysiological sensor. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提高细胞电生理传感器的测量精度。 解决方案：用于细胞电生理传感器的装置配备有电池保持芯片11和用于覆盖电池保持芯片11的侧面的基板9，以达​​到目的。 此外，电池开孔芯片11设置有连接其上表面和下表面的导电孔14。 电池保持片11包含硅作为主要成分。 基板9由玻璃形成，并且在电池孔洞芯片11的每一侧形成由至少一种氧化硅或氮化硅构成的亲水性膜16.基板9被热熔合到亲水膜16。 因此，可以减小电池保持用芯片11和基板9的两侧之间的间隙，以提高气密性，结果提高电池电生理传感器的测量精度。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2014013232A

公开(公告)日：2014-01-23

申请号：JP2013106863

申请日：2013-05-21

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： TAKAHASHI MAKOTO ,  ARIMOTO SATOSHI

IPC: G01N27/416

CPC classification number: G01N27/416 ,  G01N27/3274

Abstract: PROBLEM TO BE SOLVED: To provide a method for accurately determining the quantity of a chemical substance contained in a sample solution with an extremely low concentration of 1×10M or less.SOLUTION: There is provided a measurement system which includes a counter electrode 13, a first reference electrode 12, a first working electrode 11a, a second working electrode 11b, and a second reference electrode 14. Subsequently, a voltage (V1>V2) of V1 volt and V2 volt respectively is applied to the first working electrode 11a and the second working electrode 11b for a first predetermined period t1. When a first predetermined period t1 has elapsed, the application of the voltage to the second working electrode 11b is stopped. A sample solution 15 is left for a second predetermined period t2. Finally, a voltage difference ΔE between the second working electrode 11b and the second reference electrode 14 is measured and the concentration of the chemical substance is calculated based on the ΔE.

Abstract translation: 要解决的问题：提供一种用于精确测定1×10M以下浓度极低的试样溶液中所含的化学物质的量的方法。提供了一种测量系统，其包括对电极13， 第一参考电极12，第一工作电极11a，第二工作电极11b和第二参考电极14.随后，将V1伏特和V2伏的电压（V1> V2）分别施加到第一工作电极11a和 第二工作电极11b，第一预定时段t1。 当经过第一预定时段t1时，停止向第二工作电极11b施加电压。 样品溶液15留下第二预定时段t2。 最后，测量第二工作电极11b和第二参考电极14之间的电压差Dgr; E，并根据＆Dgr; E计算化学物质的浓度。

公开(公告)号：JP2013044587A

公开(公告)日：2013-03-04

申请号：JP2011181246

申请日：2011-08-23

Applicant: Panasonic Corp ,  パナソニック株式会社

Inventor： OKUMURA YASUAKI ,  TAKAHASHI MAKOTO ,  KAWAMURA TATSURO

IPC: G01N27/333 ,  G01N27/30 ,  G01N27/327 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To quickly and highly accurately quantify a chemical substance in a sample solution without being affected by an adsorptive inhibitor contained in the sample solution.SOLUTION: A sensor chip for quantifying a chemical substance contained in a sample solution comprises a metal electrode formed on a part or the whole surface of a solid support body. The surface of the metal electrode is covered with a self-assembly of alkyl thiol compound. The carbon number of alkyl part is 6 to 16, and the terminal group of the alkyl thiol compound includes ethylene glycol. The sample solution includes an electron carrier, and the electron carrier is 1-methoxy-5-methylphenazinium.

Abstract translation: 要解决的问题：快速，高精度地量化样品溶液中的化学物质，而不受样品溶液中所含的吸附抑制剂的影响。 解决方案：用于对包含在样品溶液中的化学物质进行定量的传感器芯片包括形成在固体支撑体的一部分或整个表面上的金属电极。 金属电极的表面被烷基硫醇化合物的自组装覆盖。 烷基部分的碳原子数为6〜16，烷基硫醇化合物的末端基包括乙二醇。 样品溶液包含电子载体，电子载体为1-甲氧基-5-甲基吩嗪。 版权所有（C）2013，JPO＆INPIT