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公开(公告)号：JP2581808B2
公开(公告)日：1997-02-12
申请号：JP25999389
申请日：1989-10-06
Applicant: SAGAMI CHEM RES
Inventor： NAGASE YUTAKA , AOYANAGI TAKAO
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公开(公告)号：JPH0733844A
公开(公告)日：1995-02-03
申请号：JP20196593
申请日：1993-07-23
Applicant: SAGAMI CHEM RES
Inventor： NAGASE YUTAKA , AOYANAGI TAKAO , MIYATA FUSAE
IPC: C08F299/02 , C08F290/00 , C08F299/04
Abstract: PURPOSE:To obtain the subject material consisting of a gel containing a specific aliphatic polyester as a main component, capable of controlling a thermal transition temperature, enabling ON-OFF control in release of a medicine in arbitrary temperature range and suitable for medicine transfer system, etc. CONSTITUTION:The objective material is composed of a gel consisting essentially of an aliphatic polyester obtained by polymerizing (A) a polyester-based polyfunctional macromonomer of formula I [R is H or 1-6C alkyl; X is H, halogen, cyano, 1-6C alkyl or phenyl; A is aliphatic polyester chain; m is 0 or 1; p is 0-6] and (B) a polyethylene glycol having a polymerization group at the end of formula II [X is X ; Y is H, alkyl, C(=0)C(X )=CH2; (n) is 5-50] in a weight ratio of the component A to the component B of (99/1 to 70/30) and average polymerization degree of the polyester chain is in the range of 5-500.
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公开(公告)号：JPH06245991A
公开(公告)日：1994-09-06
申请号：JP6142893
申请日：1993-02-26
Applicant: SAGAMI CHEM RES
Inventor： NAGASE YUTAKA , AOYANAGI TAKAO , MORIMOTO YASUNORI , SUGIBAYASHI KENJI , NATSUME HIDESHI
IPC: A61L27/00 , C08F20/10 , C08F20/26 , C08F30/08 , C08F220/02 , C08F220/28 , C08F230/08
Abstract: PURPOSE:To provide a membrane material exhibiting the nature of the skin permeability of drugs resembling the skin permeability of the drugs of the human skin by forming a copolymer of a monomer having a hydroxyalkyl group and a macromonomer having a polyorgano-siloxane chain of a prescribed copolymer compsn. CONSTITUTION:This skin model membrane consists of the copolymer having the repeating units expressed by general formulas (I) and (II), the molar ratio of the repeating unit expressed by the general formula (I) and the repeating unit expressed by (II) in an 80/20 to 1/99 range and >=1000 number average mol.wt. In the general formula (I), R is a hydrogen atom, halogen atom, cyano group, 1 to 6C alkyl group or phenyl group; R is a hydroxyalkyl group. In the formula (II), X is a hydrogen atom, halogen atom, cyano group, 1 to 6C alkyl group or phenyl group; R to R are alkyl groups or phenyl groups which may be the same or different; (p) is an integer from 2 to 6; (n) is an integer from 1 to 10.
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公开(公告)号：JPH0616799A
公开(公告)日：1994-01-25
申请号：JP5128993
申请日：1993-02-18
Applicant: SAGAMI CHEM RES
Inventor： NAGASE YUTAKA , AOYANAGI TAKAO , MIYATA FUSAE
IPC: C07C69/67 , C07C255/23 , C08F290/00 , C08F299/02 , C08G63/52 , C08G63/91 , C08L101/16
Abstract: PURPOSE:To produced a polyester-based polyfunctional macromonomer which is composed of a specific structural unit and useful in giving biodegradable polymer materials, a drug release-controlling materials or the like because of its excellent mechanical properties and tensile elongation. CONSTITUTION:The macromonomer is represented by the formula I [R is H, 1 to 16C alkyl; X is H, halogen, cyano, 1 to 6C alkyl, phenyl; A is a polyester chain comprising the recurring units of formula II (R is H, methyl, ethyl; q if 0 to 6); m is 0, 1; p is 0 to 6] and has an average degree of polymerization of 1 to 500. The compound of formula I is obtained, for example, by reaction of a triol or tetraol of formula III with a cyclic ester of formula IV followed by reaction of the product with an acid chloride of formula V. The polymerization of the macromonomer gives a polyester gel.
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公开(公告)号：JPH05139997A
公开(公告)日：1993-06-08
申请号：JP32501791
申请日：1991-11-14
Applicant: SAGAMI CHEM RES
Inventor： NAGASE YUTAKA , AOYANAGI TAKAO , AKIMOTO TOMOKO
Abstract: PURPOSE:To provide the subject low irritant and low toxic absorption accelerating agent containing a specific polyorganosiloxane and having a good percutaneous absorption-accelerating activity for medicines. CONSTITUTION:The objective absorption-accelerating agent contains a polyorganosiloxane having a carboxylic acid residue at one molecular end and represented by formula I (R -R are 1-6C alkyl, phenyl; A is 2-13C divalent alkylene or divalent alkylene bonded to a methylenephenylene; n is 1 or larger) or formula II (M is alkali metal). The compound of formula I is obtained e.g. by reacting a polyorganosiloxane having a halomethylphenyl group at one molecular end and represented by formula III with water and carbon monoxide in the presence of a group VIII transition metal element and a base. The compound of formula II is also obtained by reacting the compound of formula I with an alkali metal hydroxide. The absorption-accelerating agent is dissolved together with a medicine to be administered in a solvent such as water or an alcohol and subsequently added to a tinctura, an ointment, etc.
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Patent Agency Ranking
公开(公告)号：JPH03123787A
公开(公告)日：1991-05-27
申请号：JP25999389
申请日：1989-10-06
Applicant: SAGAMI CHEM RES
Inventor： NAGASE YUTAKA , AOYANAGI TAKAO
Abstract: NEW MATERIAL:The compound of formula I (X is H, 1-6C hydrocarbon group or halogen; R is 1-4C hydrocarbon group; R is 8-30C hydrocarbon group; Y is 1-6C bivalent hydrocarbon group). USE:A transcutaneous absorbefacient. PREPARATION:The objective compound can be produced by (1) reacting phosphorus oxychloride used as a starting raw material with a higher alcohol of formula R OH optionally in a solvent to synthesize the compound of formula II, (2) reacting the intermediate compound of formula II with the compound of formula III to synthesize the compound of formula IV as the 2nd intermediate and finally (3) reacting the intermediate with a lower alcohol of formula R OH.
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公开(公告)号：JPH01204931A
公开(公告)日：1989-08-17
申请号：JP2774788
申请日：1988-02-10
Applicant: SAGAMI CHEM RES
Inventor： MATSUI KIYOHIDE , MORI SHIGEHIRO , NAGASE YUTAKA
IPC: C08G73/10 , B01D71/64 , C08G77/42 , C08G77/455 , C08G77/48
Abstract: PURPOSE:To improve gas and liq. permeability and separability when used as a raw material of a membrane while mechanical strength, heat resistance and solvent resistance are kept, by reacting a tetracarboxylic acid dianhydride with a specified polyorganosiloxane. CONSTITUTION:A polyamic acid contg. siloxane is obtd. by reacting a tetracarboxylic acid dianhydride (a) of formula I (wherein A is a tetravalent org. group having an arom. group) and a polyorganosiloxane (b) being about equimolar to the component (a) having a diaminophenyl group on one of its terminals of formula II [wherein B is a divalent org. group; R are each a (substd.)alkyl or (substd.)phenyl provided that R and R may be each optionally different on every repeating unit; m is 1 or larger]. Then, this polyamic acid is heated and dehydrated at 100-400 deg.C to obtain the title polyimide contg. repeating units of formula III (wherein A and B may be each different on every repeating unit) and repeating units of formula IV (wherein A is a divalent org. group having an arom. group provided that A and A may be each different on every repeating unit) at a molar ratio of 100-1/0-99.
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公开(公告)号：JPS6386726A
公开(公告)日：1988-04-18
申请号：JP22956086
申请日：1986-09-30
Applicant: SAGAMI CHEM RES
Inventor： MATSUI KIYOHIDE , NAGASE YUTAKA , MORI SHIGEHIRO
Abstract: PURPOSE:To obtain a copolymer useful for selective gas separation membranes which has high oxygen permeability and outstanding separability and strength, by reaction between poly-disubstituted acetylene and polyorganosiloxane in the presence of a hydrosilylating catalyst. CONSTITUTION:The objective poly-disubstituted acetylene/polyorganosiloxane graft copolymer carrying polyorganosiloxane in the side chain can be obtained by reaction, in the presence of a hydrosilylating catalyst, between (A) a poly- disubstituted acetylene carrying C=C bond-contg. group in the side chain {pref. a copolymer constituted of recurring units of formula I [A is (substituted)alkyl, (substituted)phenyl, etc.] and recurring units of formula II (Y is C=C bond-contg. group)} and (B) a polyorganosiloxane of formula III [R -R are each (substituted)alkyl or (substituted) phenyl, in which R and R may differ with each recurring unit].
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公开(公告)号：JPS6386725A
公开(公告)日：1988-04-18
申请号：JP22955986
申请日：1986-09-30
Applicant: SAGAMI CHEM RES
Inventor： MATSUI KIYOHIDE , NAGASE YUTAKA , MORI SHIGEHIRO
IPC: C08G77/42
Abstract: PURPOSE:To readily obtain a copolymer by grafting, through a novel process, polyorganosiloxane side chain to a poly-disubstituted acetylene to introduce any quantity of polyorganosiloxane component without decreasing the molecular weight of the product. CONSTITUTION:First, a poly-disubstituted acetylene carrying C=C bond-contg. group in the side chain is allowed to react, pref. at and R are each alkyl, phenyl, etc.; m is integer, 3-6). Thence, a triorganohalogenosilane compound of formula II (R -R are each the same as R ; X is halogen) is added to the reaction system to terminate the reaction, thus obtaining the objective poly-disubstituted acetylene/polyorganosiloxane graft copolymer carrying polyorganosiloxane in the side chain. The poly-disubstituted acetylene mentioned above is, e.g., poly(2-hexyne).
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公开(公告)号：JPS61242603A
公开(公告)日：1986-10-28
申请号：JP8449685
申请日：1985-04-22
Applicant: SAGAMI CHEM RES
Inventor： MATSUI KIYOHIDE , ISHIHARA KAZUHIKO , TAJIMA RIIKO , NAGASE YUTAKA
Abstract: PURPOSE:To perform separation or concentration of a liquid mixture with extremely high efficiency by using a polymer constituted of polystyrene chain having a polysiloxane chain in a phenyl group and polystyrene chain having no polysiloxane chain. CONSTITUTION:A separation membrane is formed of two-component graft polymer comprising a recurrent unit expressed by the formula I and recurrent unit expressed by the formula II. Suitable proportion of the recurrent unit expressed by the formula I is 1-95mol%. Further, preferred mol.wt. of the copolymer is >=10,000, and the preferred film thickness is 0.01-300mum. The membrane is useful for the separation of a liquid mixture, particularly, for the separation of water-alcohol mixture. The separation is performed at -30-150 deg.C and atmospheric pressure - 100atm.
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