公开(公告)号：JP2012187252A

公开(公告)日：2012-10-04

申请号：JP2011052709

申请日：2011-03-10

Applicant: Sony Corp ,  ソニー株式会社

Inventor： KISHIMOTO TAKUYA ,  TAMADA SAKUYA

IPC: A61B3/12 ,  A61B3/10

CPC classification number: A61B3/10 ,  A61B3/1015 ,  A61B3/12 ,  A61B5/0071

Abstract: PROBLEM TO BE SOLVED: To provide a fundus imaging apparatus that can correct optical aberration by an anterior component of eyes by optimizing a wavefront shape without using a wavefront sensor.SOLUTION: The fundus imaging apparatus includes a wavefront adjuster and a detector. The wavefront adjuster is configured to adjust a wavefront of a femtosecond pulsed laser beam incident on an ocular fundus to be examined. The detector is configured to detect fluorescence generated in a multi-photon excitation process by the femtosecond pulsed laser beam incident on the ocular fundus to be examined. The wavefront adjuster provides the fundus imaging apparatus for adjusting the wavefront so that an intensity of the fluorescence detected by the detector becomes maximum or an optical aberration correction apparatus.

Abstract translation: 要解决的问题：提供一种眼底成像装置，其可以通过优化波前形状而不使用波前传感器来校正眼睛前部分量的光学像差。 解决方案：眼底成像装置包括波前调节器和检测器。 波前调整器被配置为调整入射到待检查的眼底的飞秒脉冲激光束的波前。 检测器被配置为检测通过入射到待检查的眼底的飞秒脉冲激光束在多光子激发过程中产生的荧光。 波前调整器提供用于调整波前的眼底成像装置，使得由检测器检测到的荧光的强度变得最大，或者光学像差校正装置。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2012032368A

公开(公告)日：2012-02-16

申请号：JP2011037790

申请日：2011-02-24

Applicant: Sony Corp ,  ソニー株式会社

Inventor： MATSUI ERIKO ,  TAMADA SAKUYA ,  KISHIMOTO TAKUYA ,  YASUDA AKIO

IPC: G01N21/65 ,  A61B3/12 ,  A61B3/14

CPC classification number: A61B3/1173 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/4088 ,  G01N21/65 ,  G01N33/54373 ,  G01N33/6896 ,  G01N2800/2821

Abstract: PROBLEM TO BE SOLVED: To provide a technology for non-invasively detecting substance in a biological tissue.SOLUTION: A biological substance detection system includes: a spectral data analysis device for calculating the rate of the spectral strength of a C-H band of a Raman spectrum corresponding to the substance existing in a biological tissue to the spectral strength of an amide I band, and for automatically determining the presence/absence of an amyloid beta in the substance based on the rate; and measuring equipment, for acquiring the Raman spectrum corresponding to the substance existing in the biological tissue, which is connected to the spectral data analysis device.

Abstract translation: 要解决的问题：提供用于在生物组织中非侵入性检测物质的技术。 生物物质检测系统包括：光谱数据分析装置，用于计算对应于生物组织中存在的物质的拉曼光谱的CH波段的光谱强度与酰胺I的光谱强度的比率 并且用于基于速率自动确定物质中淀粉样蛋白β的存在/不存在; 以及测量设备，用于获取与存在于生物组织中的物质相对应的拉曼光谱，其连接到光谱数据分析装置。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2011212115A

公开(公告)日：2011-10-27

申请号：JP2010081399

申请日：2010-03-31

Applicant: Sony Corp ,  Tokyo Medical & Dental Univ ,  ソニー株式会社 ,  国立大学法人 東京医科歯科大学

Inventor： TAMADA SAKUYA ,  KISHIMOTO TAKUYA ,  YASUDA AKIO ,  ONO KYOKO ,  MORITA IKUO

IPC: A61F9/007 ,  A61N5/06

Abstract: PROBLEM TO BE SOLVED: To provide a posterior sclera curing apparatus which cures the posterior sclera by irradiating the posterior sclera with light not by way of the cornea.SOLUTION: The posterior sclera curing apparatus comprises a light source for irradiating the posterior sclera with light having a wavelength corresponding to absorption characteristics of a sensitizer for collagen cross-linking reaction, a sheet-like transmission section for transmitting the light, a plate-like irradiating section for forward irradiation with the light introduced from the transmission section into sides of the plate, and a wire surrounding the irradiating section and extending along the sides of the transmission section.

Abstract translation: 要解决的问题：提供一种后巩膜固化装置，其通过用不通过角膜的光照射后巩膜来固化后巩膜。解决方案：后巩膜固化装置包括用于用后述的巩膜照射光的光源， 对应于胶原交联反应敏化剂的吸收特性的波长，用于透射光的片状透射部分，用于从从透射部分引入到板的侧面的光正向照射的板状照射部分， 以及围绕照射部并且沿着透射部的侧面延伸的线。

公开(公告)号：JP2011085578A

公开(公告)日：2011-04-28

申请号：JP2010148819

申请日：2010-06-30

Applicant: Sony Corp ,  ソニー株式会社

Inventor： MACHIDA KENZO ,  KISHII NORIYUKI ,  SAKAMOTO NAOHISA ,  ICHIMURA MARI ,  ITO KAZUTAKA ,  KISHIMOTO TAKUYA

IPC: G01N21/64 ,  G01N21/78 ,  G01N33/543

CPC classification number: G01N33/54366 ,  G01N21/6452

Abstract: PROBLEM TO BE SOLVED: To provide a microbead analysis method capable of highly accurately detecting fluorescence from a fluorescent material or the like used for labeling a target substance without requiring complicated preparation processes by excluding the effects of noise fluorescence caused by an identification pattern. SOLUTION: A microbead 1 is formed in a columnar shape comprising an upper surface 11 and a lower surface 12 opposed to each other approximately in parallel with each other and sides 13 continuous to these surfaces. The identification pattern is formed at least in either the upper surface 11 or the lower surface 12, and a solid phase of a substance having affinity to a substance to be detected is formed in the surface of the microbead 1. Fluorescence to be detected in the surface of the microbead 1 on the basis of the interaction between the substance to be detected and the substance having affinity to the substance to be detected is detected from a region including both of a region 112 in which the identification pattern is not formed among the upper surface 11 and the lower surface 12 and the sides 13 in the microbead analysis method. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 解决方案：提供一种能够高效准确地检测用于标记目标物质的荧光材料等的荧光的微珠分析方法，而不需要复杂的制备方法，通过排除由识别图案引起的噪声荧光的影响 。 解决方案：微珠1形成为包括彼此大致平行地彼此相对的上表面11和下表面12以及与这些表面连续的侧面13的柱状。 识别图案至少形成在上表面11或下表面12中，并且在微珠1的表面中形成对被检测物质具有亲和性的物质的固相。荧光在 基于待检测物质与对待检测物质具有亲和性的物质之间的相互作用的微珠1的表面，从包含未形成识别图案的区域112的区域中检测出来 表面11和下表面12以及侧面13的微珠分析方法。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010043983A

公开(公告)日：2010-02-25

申请号：JP2008208844

申请日：2008-08-14

Applicant: Sony Corp ,  ソニー株式会社

Inventor： KISHIMOTO TAKUYA ,  WATANABE HIDETOSHI ,  ONISHI MICHIHIRO

IPC: G01N21/64

Abstract: PROBLEM TO BE SOLVED: To provide an optical measuring device capable of analyzing a trace substance with high sensitivity by efficiently applying excitation light from a light source to a sample and efficiently guiding light emitted from the sample to a photodetector.
SOLUTION: In the optical measuring device A, an optical path is composed by a bundle of optical fibers 4, where optical fibers 4a-4c for excitation light for guiding light emitted from light sources 1a-1c to the sample for illumination and an optical fiber 4d for radiation light for guiding radiation light emitted from the excited sample to the photodetector 8 are bundled by surrounding one optical fiber 4d for radiation light positioned at the center by the plurality of optical fibers 1a-1c for excitation light.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种能够通过有效地将来自光源的激发光施加到样品并且有效地将从样品发射的光引导到光电检测器的方式来高灵敏度地分析痕量物质的光学测量装置。 解决方案：在光学测量装置A中，光路由一束光纤4组成，其中用于将从光源1a-1c发射的光引导到用于照明的样品的激发光的光纤4a-4c，以及 将用于将从被激发的样品发射的辐射光引导到光电检测器8的辐射光的光纤4d通过围绕用于激发光的多个光纤1a-1c位于中心的用于辐射光的一个光纤4d而被捆扎。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2010005062A

公开(公告)日：2010-01-14

申请号：JP2008166731

申请日：2008-06-26

Applicant: Sony Corp ,  ソニー株式会社

Inventor： KISHIMOTO TAKUYA ,  ONISHI MICHIHIRO ,  WATANABE HIDETOSHI

IPC: A61B10/00 ,  G01N21/65 ,  G01N33/72

CPC classification number: G01N21/65 ,  A61B5/14546 ,  A61B5/1455 ,  G01N2021/653 ,  G01N2021/656

Abstract: PROBLEM TO BE SOLVED: To provide a method of measuring the quantity of an in-vivo substance capable of measuring with easier operation than the usual method of measuring the quantity of in-vivo substance, and detecting even the in-vivo substance in a biological tissue.
SOLUTION: A method provided for measuring the quantity of an in-vivo substance includes the steps of: irradiating an in-vivo substance with two near infrared femtosecond laser beams of different frequencies; detecting coherent anti-Stokes Raman scattering light emitted from the in-vivo substance due to coincidence of the frequency difference between the two near infrared femtosecond laser beams with a natural frequency of the in-vivo substance; and measuring the quantity of the in-vivo substance based on a peak intensity of an obtained Raman scattering spectrum.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种比通常测量体内物质量的常规方法更容易操作的能够测量的体内物质的量的测量方法，甚至检测体内物质 在生物组织中。 解决方案：用于测量体内物质的量的方法包括以下步骤：用两个不同频率的近红外飞秒激光照射体内物质; 检测由于体内物质的固有频率引起的两个近红外飞秒激光束之间的频率差的一致性，检测从体内物质发射的相干反斯托克斯拉曼散射光; 并且基于获得的拉曼散射光谱的峰强度来测量体内物质的量。 版权所有（C）2010，JPO＆INPIT