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    PREPARATION OF DIPEPTIDE-ALKYLESTERS
    21.
    发明专利
    PREPARATION OF DIPEPTIDE-ALKYLESTERS 未知

    公开(公告)号：CA1003408A

    公开(公告)日：1977-01-11

    申请号：CA156314

    申请日：1972-11-14

    Applicant: STAMICARBON

    Inventor： BOESTEN WILHELMUS H J

    IPC: C07C231/00 ,  A23L27/30 ,  C07C67/00 ,  C07C231/14 ,  C07D307/66 ,  C07K5/075

    Abstract: A process for preparing aspartyl alpha -amino acid lower alkyl esters is disclosed, wherein an N-protected aspartic acid anhdyride is reacted with an alpha -amino acid lower alkyl ester at a temperature of about -10 to +50 DEG C, and at a pH of 4-12, in an aqueous solvent. After the reaction, the N-protective group is removed to produce the desired aspartyl alpha -amino acid lower alkyl ester which has a peptide linkage.

    PROCESS FOR THE PREPARATION OF ASPARTYLPHENYLALANINE METHYL ESTER FROM N-FORMYLASPARTYLPHENYLALANINE METHYL ESTER
    22.
    发明专利
    PROCESS FOR THE PREPARATION OF ASPARTYLPHENYLALANINE METHYL ESTER FROM N-FORMYLASPARTYLPHENYLALANINE METHYL ESTER 未知

    公开(公告)号：CA1322626C

    公开(公告)日：1993-09-28

    申请号：CA565465

    申请日：1988-04-29

    Applicant: STAMICARBON

    Inventor： BOESTEN WILHELMUS H J ,  DASSEN BERNARDUS H N

    IPC: C07K1/06 ,  C07K5/06 ,  C07K5/075

    Abstract: AE 5682 The invention relates to a process for the preparation of aspartylphenylalanine methyl ester from N-formylaspartylalanine methyl ester by treatment with an acid, characterized in that N-formyl-aspartylalanine methyl ester is treated at 30-60.degree.C with at least 0.5 molar equivalent oxalic acid per mole of N-formyl-aspartylphenyl-alanine methyl ester in a solvent mixture in which N-formylaspartylphenylalanine methyl ester dissolves well and in which the oxalic acid salt of aspartylphenylalanine methyl ester is poorly soluble, after which the oxalic acid salt of aspartylphenylalanine methyl ester is removed by filtration, dissolved in water and subsequently neutralized with the aid of an inorganic base with formation of free aspartylphenylalanine methyl ester.

    PROCESS FOR RACEMIZING AN OPTICALLY ACTIVE N-BENZYLIDENE AMINO-ACID AMIDE
    23.
    发明专利
    PROCESS FOR RACEMIZING AN OPTICALLY ACTIVE N-BENZYLIDENE AMINO-ACID AMIDE 未知

    公开(公告)号：CA1292434C

    公开(公告)日：1991-11-26

    申请号：CA506281

    申请日：1986-04-10

    Applicant: STAMICARBON

    Inventor： BOESTEN WILHELMUS H J ,  SCHOEMAKER HANS E ,  DASSEN BERNARDUS H N

    IPC: C07B55/00 ,  C07B31/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/16 ,  C07C237/06 ,  C07C237/30 ,  C07C241/00 ,  C07C251/02 ,  C12P13/04 ,  C12P13/08 ,  C12P41/00 ,  C12P13/02

    Abstract: AE 3631 The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base per litre solution. The invention further relates to a process for preparing an L-amino acid by enzymatic separation of the corresponding DL-amino-acid amide with an enzyme preparation from Pseudomonas putida, in which process also unconverted D-amino-acid amide is left behind in solution, characterized in that benzaldehyde is added to the solution, during which addition a precipitate of D-N-benzylidene aminoacid amide is being formed, this precipitate is subsequently, after being separated off, dissolved in an acetone-water mixture, 0.08-0.15 mole KOH/Litre solution is subsequently added, the resulting solution is stirred for 1-20 hours at 20-60.degree.C, sulphuric acid is then added until the pH of the solution is 5 and the resulting sulphuric acid salt of the DL-amino-acid amide is finally, after isolation at pH 8-10, converted into the DL-amino-acid amide and this DL-amino-acid is used again. 22772-1062

    26.
    发明专利
    未知

    公开(公告)号：DK526385A

    公开(公告)日：1986-05-16

    申请号：DK526385

    申请日：1985-11-14

    Applicant: STAMICARBON

    Inventor： KERKHOFFS PIETER LAURENS ,  BOESTEN WILHELMUS H J

    IPC: C12P41/00 ,  C12N9/80 ,  C12P13/04 ,  C12P13/08 ,  C12R1/40 ,  C12P

    Abstract: @ The invention relates to a process for the preparation of L-a-amino acid and D-a-amino acid amide from DL-a-aminoacid amide by contacting the DL-a-amino acid amide in an aqueous solution with an a-amino acyl amidase containing preparation obtained from a culture of Pseudomonas putida in the presence of traces of bivalent metal ions as activator, characterized in that the aqueous solution also contains a potassium salt selected from the group consisting of potassium sulphate and potassium chloride.The invention further relates to a process for the preparation of a L-α-amino acid and D-α-amino acid amide starting from the corresponding aldehyde, potassium cyanide and ammoniumsulphate, subsequent treatment with a ketone and potassiumhydroxide and finally subjecting to enzymatic hydrolysis with a preparation obtained from Pseudomonas putida.

    PREPARATION OF PEPTIDES
    29.
    发明专利
    PREPARATION OF PEPTIDES 未知

    公开(公告)号：CA955933A

    公开(公告)日：1974-10-08

    申请号：CA105466

    申请日：1971-02-16

    Applicant: STAMICARBON

    Inventor： DAHLMANS JOHANNES J ,  BOESTEN WILHELMUS H J

    IPC: C07K1/02 ,  C07K1/08

    Abstract: 1331714 Peptides STAMICARBON NV 19 April 1971 [18 Feb 1970] 23565/71 Heading C2C Peptides are prepared by reacting a free amino hydrogen of an amino acid or an initial peptide or a compound derived therefrom (e.g. an ester or amide or an amino acid or peptide bound to a solid polymeric carrier by its C- terminal COOH group) with a 2-thionooxazolidone-5 compound of formula wherein R 1 is H or an α-amino acid residue, R 2 is H or optionally substituted C 1-3 alkyl and R 3 is H or C 1-3 alkyl, or wherein R 1 and R 3 together represent a C 1-3 alkylene group forming an α-amino acid residue in which the amino group forms part of a ring. N-thiocarboxylated derivative is first which may be dethiocarboxylated by lowering the pH below 5. The first step is preferably carried out at a pH between 8 and 12.

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