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    PRODUCTION OF (S)-2-(4-CHLOROPHENYL) 3-METHYLBUTYRATE
    22.
    发明专利
    PRODUCTION OF (S)-2-(4-CHLOROPHENYL) 3-METHYLBUTYRATE 失效

    公开(公告)号：JPH05227981A

    公开(公告)日：1993-09-07

    申请号：JP3325992

    申请日：1992-02-20

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MURAI RIKA ,  MASUTOMO SHIYUNICHI ,  KUMAGAI KAZUO ,  MITSUTA MASARU

    IPC: A01N63/02 ,  C07C233/11 ,  C12N1/20 ,  C12P7/40 ,  C12R1/38

    Abstract: PURPOSE:To produce the subject compound of high optical purity useful as a raw material of an insecticide in a high yield by allowing a microorganism belonging to Pseudomonas to react on (chlorophenyl)-methyl butyronitrile. CONSTITUTION:The objective compound of formula III is obtained by allowing a microorganism [preferably Pseudomonas sp. B21C9 strain (FERMBP-3737)] belonging to Pseudomonas to react on 2-(4-chlorophenyl)-3-methylbutyronitrile of formula I or 2-(4-chlorophenyl)-3-methylbutylamide of formula II. The above- mentioned reaction is carried out with stirring preferably at pH 6 to 9 and at 20 to 40 deg.C. The reaction time is recommendably 1 to 40hr in general.

    NEW MICROORGANISM
    25.
    发明专利
    NEW MICROORGANISM 失效

    公开(公告)号：JPH04234991A

    公开(公告)日：1992-08-24

    申请号：JP47491

    申请日：1991-01-08

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MITSUTA MASARU ,  KOMAKI RYOHEI ,  NABESHIMA NARIYASU

    IPC: C12N1/20 ,  C12P7/40 ,  C12R1/06

    Abstract: PURPOSE:To provide a method for biologically producing (+)-chrysanthemumic acid ester or (+)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid by the use of a microorganism. CONSTITUTION:Arthrobacter SC-6-98-28 strain (FERM P-11851) having a high esterase activity and obtained by treating Arthrobacter.globiformis IFO-12958 strain with NTG. The microorganism hydrolyzes racemic chrysanthemumic acid or racemic 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid ester into the (+)-chrysanthemumic acid or the (+)-3-(2,2-dichlorovinyl)-2,2- dimethylcyclopropanecarboxylic acid.

    BIOCHEMICAL PRODUCTION OF (R)-4-HYDROXY-2-CYCLOPENTENONE
    27.
    发明专利
    BIOCHEMICAL PRODUCTION OF (R)-4-HYDROXY-2-CYCLOPENTENONE 失效

    公开(公告)号：JPS62244396A

    公开(公告)日：1987-10-24

    申请号：JP9024386

    申请日：1986-04-18

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MITSUTA MASARU ,  ANDO YASUMITSU ,  KISHIMOTO FUMITAKA

    IPC: C12P41/00

    Abstract: PURPOSE:To obtain the titled cyclopentenone at a low cost, by reacting a specific compound with an esterase of a microorganism of the genus Alcaligenes and reacting the resultant optically active cyclopentenone containing the (R)- isomer, etc., with an organic carboxylic acid anhydride, etc. CONSTITUTION:An esterase (ES) derived from a microorganism of the genus Alcaligenes is reacted with an organic carboxylic acid ester (CE) of a racemic 4-hydroxy-2-cyclopentenone (4HS) expressed by formula I (R is 1-18C alkyl, 2-18C alkenyl or 2-18C alkynyl) to carry out asymmetric hydrolysis and give an optically active 4HS containing >=75% (R)-isomer. An organic carboxylic acid halide expressed by formula II (X is Cl or Br) or organic carboxylic acid anhydride expressed by formula III to afford CE of optically active 4HS expressed by formula IV (mark * indicates asymmetric carbon atom), which is then reacted with the above-mentioned ES to give optically active 4HS containing >=90% (R)-isomer. The resultant optically active isomer is further reacted with the carboxylic acids expressed by formulas I-II, etc., to afford CE of the optically active 4HS, which is then reacted with the above-mentioned ES to provide the aimed (R)-4HS containing >=97% (R)-isomer.

    BIOCHEMICAL PRODUCTION OF OPTICALLY ACTIVE 1-ETHYNYL-2-METHYL-2-PENTENOL
    28.
    发明专利
    BIOCHEMICAL PRODUCTION OF OPTICALLY ACTIVE 1-ETHYNYL-2-METHYL-2-PENTENOL 失效

    公开(公告)号：JPS6229993A

    公开(公告)日：1987-02-07

    申请号：JP16955585

    申请日：1985-07-30

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MITSUTA MASARU ,  ANDO YASUMITSU ,  HIROHARA HIDEO

    IPC: C12P41/00 ,  C12P7/02 ,  C12P7/62 ,  C12R1/01 ,  C12R1/025 ,  C12R1/05 ,  C12R1/06 ,  C12R1/38

    Abstract: PURPOSE:To obtain (S)-1-ethynyl-2-methyl-2-pentenol in high optical purity and yield, by reacting esterase produced by a specific microorganism with an organic carboxylic acid ester of a specific (R,S)-1-ethynyl-2-methyl-2-pentenol to asymmetrically hydrolyze the ester. CONSTITUTION:Esterase produced by a microorganism of the genus Arthrobacter, Alcaligenes, Achromobacter, Chromobacterium, Humicola (Thermomyces) or Pseudomonas is reacted with an organic carboxylic acid ester of (R,S)-1-ethynyl-2-methyl-2-pentenol expressed by the formula (R is H, 1-18C alkyl group, 2-18C alkenyl group or 2-18C alkynyl group) to asymmetrically hydrolyze the ester into the organic carboxylic acid ester of (S)-1-ethynyl-2- methyl-2-pentenol [referred to as S-isomer] and (R)-1-ethynyl-2-methyl-2-pentenol, which are then separated and recovered. The resultant organic carboxylic acid ester of the S-isomer is then deacylated.

    EXTRACTION OF GLUCOSE ISOMERASE
    29.
    发明专利
    EXTRACTION OF GLUCOSE ISOMERASE 失效

    公开(公告)号：JPS54154594A

    公开(公告)日：1979-12-05

    申请号：JP6289378

    申请日：1978-05-25

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： HIROHARA HIDEO ,  NABESHIMA NARIYASU ,  MITSUTA MASARU ,  NAGASE TSUNEYUKI

    IPC: C12N1/06 ,  C12N9/92

    Abstract: PURPOSE:A specific method is applied to the extraction of glucose isomerase from microorganisms including the enzyme, thus obtaining the enzyme in high activity yield (over 100%) with industrial advantage. CONSTITUTION:The extraction of glucose isomerase from the suspended cells of microoranism containing the same is effected by the high pressure diffierentiation process using a suspension with a concentration of 1-20, preferably 3-12wt% under a pressure of 400-700, preferably 450-600 kg/cm . For example, the cell dispersion pressurized to above pressure is jectted out of fine gaps as high speeds over 10 km/min and reduced instantaneously to the atmospheric or lower pressure. Thus, the dispersion is homogenized and the extraction is effected.

    PROTEIN, ITS GENE AND THEIR USE
    30.
    发明专利
    PROTEIN, ITS GENE AND THEIR USE 失效

    公开(公告)号：JP2000342276A

    公开(公告)日：2000-12-12

    申请号：JP2000075752

    申请日：2000-03-17

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： TAKASHIMA YOSHIKI ,  WIESER MARCO ,  MITSUTA MASARU

    IPC: C12N15/09 ,  C07K14/35 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P13/00 ,  C12P21/02

    Abstract: PROBLEM TO BE SOLVED: To provide a new protein having a specific amino acid sequence, capable of converting acetophenone into optically active 1-phenylethylamine in the presence of racemic sec-butylamine and useful for the production of optically active amino compound, etc. SOLUTION: This new protein contains the amino acid sequence expressed by formula, an amino acid sequence obtained by substituting a part of amino acids of the amino acid sequence expressed by the formula with other amino acids or an amino acid sequence of a protein capable of converting acetophenone into optically active 1-phenylethylamine in the presence of racemic sec- butylamine and having an amino acid homology of >=60% with the amino acid sequence expressed by formula and is useful for the production of an optically active amino compound in high efficiency. The protein can be produced by culturing Mycobacterium aurum SC-S423 strain in a culture medium, centrifuging the cultured liquid to collect the cultured bacterial cell, disintegrating and extraction-treating the cell and fractionating and purifying the extracted liquid.

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