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21.发明授权Magnetic particles for nucleic acid sequencing and method of sequencing nucleic acid using the same 失效用于核酸测序的磁性颗粒和使用其的测序核酸的方法公开(公告)号：US08361717B2
公开(公告)日：2013-01-29
申请号：US12580325
申请日：2009-10-16
Applicant: Su-hyeon Kim
Inventor： Su-hyeon Kim
CPC classification number: C12Q1/6874
Abstract: Provided are magnetic particles for nucleic acid sequencing and a method of sequencing nucleic acid using the same. The nucleotide sequence of a target nucleic acid may be efficiently determined using the magnetic particles and the method of sequencing nucleic acid using the same.
Abstract translation: 提供用于核酸测序的磁性颗粒和使用其进行核酸测序的方法。 靶核酸的核苷酸序列可以使用磁性粒子和使用其进行核酸测序的方法有效地测定。
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公开(公告)号：US07910343B2
公开(公告)日：2011-03-22
申请号：US12059250
申请日：2008-03-31
Applicant: Su-hyeon Kim , Jeong-gun Lee
Inventor： Su-hyeon Kim , Jeong-gun Lee
IPC: C12N13/00
CPC classification number: C12M47/06 , B01L3/5027 , C12N1/066 , C12N13/00 , G01N1/44 , Y10T137/2496 , Y10T436/25
Abstract: A cell lysis device for lysing cells or viruses, comprising a cell lysis tube having a sample inlet; a pump connected to the cell lysis tube for transferring a sample into the tube; a sealing unit for reversibly sealing a specific region of the tube; and a laser source for generating a laser is provide. Further, a method of lysing cells or viruses using the cell lysis device is provide. The method comprises introducing a sample containing cells or viruses and optionally magnetic beads to the cell lysis tube through the sample inlet; transferring the sample to a specific region in the cell lysis tube by means of the pump; temporarily sealing the region of the cell lysis tube where the sample is placed with the sealing unit; irradiating the sample with the laser; removing the sealing unit from the cell lysis tube; and discharging the sample from the cell lysis tube by means of the pump.
Abstract translation: 一种用于裂解细胞或病毒的细胞裂解装置，包括具有样品入口的细胞裂解管; 连接到细胞裂解管的泵，用于将样品转移到管中; 用于可逆地密封管的特定区域的密封单元; 并提供用于产生激光的激光源。 此外，提供使用细胞裂解装置裂解细胞或病毒的方法。 该方法包括通过样品入口将含有细胞或病毒的样品和任选的磁珠引入细胞裂解管; 通过泵将样品转移到细胞裂解管中的特定区域; 用密封单元临时密封放置样品的细胞溶解管的区域; 用激光照射样品; 从细胞裂解管中取出密封单元; 并通过泵从细胞裂解管中排出样品。
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公开(公告)号：US20070035567A1
公开(公告)日：2007-02-15
申请号：US11503786
申请日：2006-08-14
Applicant: Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
Inventor： Su-hyeon Kim , Jeong-gun Lee , Jong-suk Chung , Hye-jung Cho , Nam Huh , In-seok Kang , Beom-seok Lee
IPC: B41J29/38
CPC classification number: B41J2/06 , B01J19/0046 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B41J2/04535 , B41J2/0456 , B41J2/04576
Abstract: A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.
Abstract translation: 用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔 使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。
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公开(公告)号：US20060185584A1
公开(公告)日：2006-08-24
申请号：US11341033
申请日：2006-01-27
Applicant: Su-hyeon Kim , Jun-hong Min , Kak Namkoong
Inventor： Su-hyeon Kim , Jun-hong Min , Kak Namkoong
IPC: C30B11/00
CPC classification number: B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2400/0409 , Y10T117/10
Abstract: Provided are a microfluidic chip and a microfluidic manipulating apparatus including the same. The microfluidic chip includes at least one microfluidic manipulating unit formed in a substrate. The microfluidic manipulating unit includes: a plurality of microchannels formed in the substrate; an inlet formed at a first end of the microchannel and exposed through the substrate; a trap formed at the microchannel; a chamber connected to a second end of the microchannel; and an outlet connected to the chamber and exposed through the substrate.
Abstract translation: 提供了一种微流控芯片和包括该微流控芯片的微流控操纵装置。 微流体芯片包括形成在基板中的至少一个微流体操纵单元。 微流体操纵单元包括：形成在基板中的多个微通道; 入口，其形成在所述微通道的第一端处并暴露于所述基底; 在微通道处形成的陷阱; 连接到所述微通道的第二端的室; 以及连接到室并通过基板暴露的出口。
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25.发明申请Novel hydrogel copolymer, substrate coated with the copolymer, method of producing microarray using the copolymer, and microarray produced by the method 有权新型水凝胶共聚物，用共聚物涂布的基材，使用该共聚物制造微阵列的方法，以及通过该方法制备的微阵列公开(公告)号：US20060160120A1
公开(公告)日：2006-07-20
申请号：US11334145
申请日：2006-01-17
Applicant: In-ho Lee , Jun-hong Min , Su-hyeon Kim
Inventor： In-ho Lee , Jun-hong Min , Su-hyeon Kim
CPC classification number: C12N11/06 , B82Y30/00 , B82Y40/00 , C08F220/28 , C08F220/56 , C08F220/60 , C08F230/08 , C12Q1/6837 , G01N2035/00158 , Y10S524/916
Abstract: A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the hydrogel copolymer makes efficient removal of protein and high integration of nucleic acid and protein on a substrate for a microarray possible.
Abstract translation: 提供一种新型水凝胶共聚物，用共聚物涂布的基材，使用该共聚物制备微阵列的方法，以及通过该方法制备的微阵列。 使用水凝胶共聚物可有效去除蛋白质，核基酸和蛋白质在基质上的高度整合可用于微阵列。
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Patent Agency Ranking
公开(公告)号：US08597572B2
公开(公告)日：2013-12-03
申请号：US12128680
申请日：2008-05-29
Applicant: Su-hyeon Kim , Yoon-kyoung Cho , Jeong-gun Lee
Inventor： Su-hyeon Kim , Yoon-kyoung Cho , Jeong-gun Lee
IPC: G01N33/50
CPC classification number: G01N35/00732 , G01N35/00069 , G01N35/08 , G01N2035/00752 , Y10T436/11
Abstract: Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantization of a test.
Abstract translation: 本发明提供一种微流体系统的自动分析方法和装置。 该装置包括用于识别微流体系统中的盘或芯片的装置，通过根据识别的类型自动加载DB执行操作和检测，并执行测试的量化。
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公开(公告)号：US07784911B2
公开(公告)日：2010-08-31
申请号：US11747043
申请日：2007-05-10
Applicant: Kui-hyun Kim , Byung-chul Kim , Kwang-ho Cheong , Su-hyeon Kim
Inventor： Kui-hyun Kim , Byung-chul Kim , Kwang-ho Cheong , Su-hyeon Kim
IPC: B41J2/06
CPC classification number: B01J19/0046 , B01J2219/00371 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/0262 , B01L2300/0819 , B01L2400/027 , C40B60/14
Abstract: An apparatus and method which print a biomolecular droplet onto a solid substrate using an electric charge concentration effect comprises: a needle shaped electric field forming electrode which is made of a conductive material, is disposed vertically, and comprises an accommodating area and a nozzle formed on a bottom end of the accommodating area; a solid substrate which is electrically grounded, is disposed below the electric field forming electrode, and comprises a moisture thin film and a target surface onto which the biomolecular droplet is discharged from the nozzle of the electric field forming electrode; and an open circuit type voltage applying unit which is electrically connected to the electric field forming electrode, applies a charge to the electric field forming electrode, and causes the biomolecular droplet to be ejected onto the target surface.
Abstract translation: 使用电荷浓度效应将生物分子液滴印刷到固体基质上的装置和方法包括：由导电材料制成的针形电场形成电极垂直设置，并且包括容纳区域和形成在 容纳区域的底端; 电气接地的固体基板设置在电场形成电极的下方，并且包括湿气薄膜和生物分子液滴从电场形成电极的喷嘴排出的目标表面; 以及与电场形成电极电连接的开路型电压施加单元，向电场形成电极施加电荷，并使生物分子液滴喷射到目标表面上。
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28.发明授权Optical detection apparatus, optical detection method, and microfluidic system including the optical detection apparatus 有权光学检测装置，光学检测方法和包括光学检测装置的微流体系统公开(公告)号：US07692794B2
公开(公告)日：2010-04-06
申请号：US11972266
申请日：2008-01-10
Applicant: Su-hyeon Kim , Jeong-gun Lee
Inventor： Su-hyeon Kim , Jeong-gun Lee
IPC: G01N21/25
CPC classification number: G01N21/07 , G01N21/253 , G01N21/276 , G01N21/314
Abstract: Provided are an optical detection apparatus, a microfluidic system including the same, and an optical detection method. The optical detection apparatus including: at least one light emission unit which emits light of a predetermined wavelength band; at least one light receiving unit which is disposed such that the light receiving unit receives the light emitted from the light emission unit and generates an electrical signal according to the intensity of the light received, wherein the number of light receiving units is the same as the number of light emission units; a rotation operating unit which rotates a disk-type microfluidic apparatus comprising at least one detection chamber in which a sample is to be loaded such that the detection chamber is disposed in a light pathway between the light emission unit and the light receiving unit; and a processor which measures a property of the sample contained in the detection chamber using the electrical signal generated by the light receiving unit.
Abstract translation: 提供了一种光学检测装置，包括该光学检测装置的微流体系统和光学检测方法。 所述光学检测装置包括：发射预定波长带的光的至少一个发光单元; 至少一个光接收单元，其设置成使得所述光接收单元接收从所述发光单元发射的光并根据所接收的光的强度产生电信号，其中所述光接收单元的数量与 发光单位数量; 旋转操作单元，其旋转盘式微流体装置，其包括至少一个检测室，其中样品将被装载，使得所述检测室设置在所述发光单元和所述光接收单元之间的光路径中; 以及处理器，其使用由光接收单元生成的电信号来测量包含在检测室中的样品的性质。
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29.发明授权Hydrogel copolymer, substrate coated with the copolymer, method of producing microarray using the copolymer, and microarray produced by the method 有权水凝胶共聚物，用共聚物涂布的基材，使用共聚物制备微阵列的方法，以及通过该方法制备的微阵列公开(公告)号：US07572644B2
公开(公告)日：2009-08-11
申请号：US11334145
申请日：2006-01-17
Applicant: In-ho Lee , Jun-hong Min , Su-hyeon Kim
Inventor： In-ho Lee , Jun-hong Min , Su-hyeon Kim
IPC: G01N33/547 , G01N33/544 , G01N33/53 , C12M1/34 , C07K1/14 , C07D207/00
CPC classification number: C12N11/06 , B82Y30/00 , B82Y40/00 , C08F220/28 , C08F220/56 , C08F220/60 , C08F230/08 , C12Q1/6837 , G01N2035/00158 , Y10S524/916
Abstract: A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the hydrogel copolymer makes efficient removal of protein and high integration of nucleic acid and protein on a substrate for a microarray possible.
Abstract translation: 提供一种新型水凝胶共聚物，用共聚物涂布的基材，使用该共聚物制备微阵列的方法，以及通过该方法制备的微阵列。 使用水凝胶共聚物可有效去除蛋白质，核基酸和蛋白质在基质上的高度整合可用于微阵列。
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公开(公告)号：US07465545B2
公开(公告)日：2008-12-16
申请号：US11341033
申请日：2006-01-27
Applicant: Su-hyeon Kim , Jun-hong Min , Kak Namkoong
Inventor： Su-hyeon Kim , Jun-hong Min , Kak Namkoong
CPC classification number: B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2400/0409 , Y10T117/10
Abstract: Provided are a microfluidic chip and a microfluidic manipulating apparatus including the same. The microfluidic chip includes at least one microfluidic manipulating unit formed in a substrate. The microfluidic manipulating unit includes: a plurality of microchannels formed in the substrate; an inlet formed at a first end of the microchannel and exposed through the substrate; a trap formed at the microchannel; a chamber connected to a second end of the microchannel; and an outlet connected to the chamber and exposed through the substrate.
Abstract translation: 提供了一种微流控芯片和包括该微流控芯片的微流控操纵装置。 微流体芯片包括形成在基板中的至少一个微流体操纵单元。 微流体操纵单元包括：形成在基板中的多个微通道; 入口，其形成在所述微通道的第一端处并暴露于所述基底; 在微通道处形成的陷阱; 连接到所述微通道的第二端的室; 以及连接到室并通过基板暴露的出口。
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