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    1,2,4-TRIAZINE-3,5-DIONE DERIVATIVES, THEIR PRODUCTION AND USE THEREOF
    21.
    发明专利
    1,2,4-TRIAZINE-3,5-DIONE DERIVATIVES, THEIR PRODUCTION AND USE THEREOF 未知

    公开(公告)号：CA2214256A1

    公开(公告)日：1998-02-28

    申请号：CA2214256

    申请日：1997-08-29

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： MIKI HIDEKI ,  IWANAGA KOICHI ,  HAYASHI TOSHIKATSU ,  AOKI ISAO

    IPC: C07D253/075 ,  C07D401/10 ,  A61K31/53 ,  A01N43/707

    Abstract: The present invention relates to compounds represented by the formula: wherein R1 is (1) an optionally substituted alkyl group which may be bonded through a hetero atom, (2) an optionally substituted acyl group, (3) an alkylsulfonyl group, (4) an alkylsulfinyl group, or (5) an optionally substituted sulfamoyl group; A is -N= or -CH=; R2 is a hydrogen atom or an alkyl group which may optionally be substituted with halogen and which may be bonded through a hetero atom; X1 is halogen or a lower alkyl group; X2 is a hydrogen atom or a fluorine atom; R3 is a hydrogen atom, halogen or a lower alkyl group; and R4 is a hydrogen atom, an optionally substituted alkyl group or an acyl group, provided that when R1 is (1) a C1-4 alkanoyl group, (2) benzoyl, (3) trifluoroacetyl, (4) sulfamoyl which may optionally be substituted with a C1-4 alkyl group, (5) a C1-4 alkyl group which may optionally be substituted with hydroxy, halogen or a C1-3 alkoxy group, (6) amino which is substituted with a C1-4 alkyl group, A is -CH=, R2 is a hydrogen atom, X1 is a chlorine atom, R3 is a chlorine atom, and X2 is a hydrogen atom, then R4 is an optionally substituted alkyl group or an optionally substituted acyl group; or salts thereof, their production and use thereof. These compounds and salts thereof are useful as anti-protozoal agents.

    Triazine derivative, production and use thereof.
    30.
    发明专利
    Triazine derivative, production and use thereof. 未知

    公开(公告)号：GR3029856T3

    公开(公告)日：1999-07-30

    申请号：GR990400944

    申请日：1999-04-05

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： MIKI HIDEKI ,  IWANAGA KOICHI ,  MATSUNO TOSHIMI

    IPC: A23K50/15 ,  A61K31/53 ,  A61P33/02 ,  C07D253/06 ,  C07D253/075 ,  C07D401/04 ,  C07D401/10 ,  C07D403/12 ,  C07D413/10 ,  C07D417/10 ,  C07D253/07

    Abstract: The present invention provides a novel triazine derivative of the formula wherein ring A is an optionally substituted aromatic group which be; X is an oxygen or sulfur atom; R and R are each a hydrogen atom or an optionally substituted hydrocarbon residue or heterocyclic group which may bound through a heteroatom; R and R are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen or sulfur atom, or taken together, represent =S; R and R are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen, nitrogen or sulfur atom; R and R , and R and R , may each bind together to form a chemical bond; provided that where ring A is a phenyl group having at least a halogen atom in position-2 or 4 and X is an oxygen atom, R and R do not conjoinedly represent a chemical bond and an antiprotozoan composition containing the same or salt thereof.

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