公开(公告)号：JPH0347132A

公开(公告)日：1991-02-28

申请号：JP10985390

申请日：1990-04-24

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MATSUNO TOSHIMI ,  HARIGUCHI FUMIO ,  OKAMOTO TSUTOMU

IPC: C07H15/04 ,  A61K31/335 ,  A61K31/35 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/715 ,  A61K36/00 ,  A61K36/185 ,  A61K36/45 ,  A61K36/54 ,  A61K45/06 ,  A61P33/02

Abstract: PURPOSE:To obtain preventive and curing drug exhibiting synergistic effect and capable of suppressing protozoa disease with practically possible range of administration dose by combining plant component having antiprotozoal activity and ionophores antibiotic. CONSTITUTION:The aimed preventive and curing drug for protozoa disease is composed of (A) plant component having antiprotozoal activity, e.g. condensed type tannin, resinous glucoside, magnolol, derivative of said substances or plant body containing said substances and (B) ionophores antibiotic, e.g. monensin, narasin, salinomycin, lasalocid, carriomycin or maduramicin. Said drug is preferably administrated with adding to feed and the adding amount is suitably 0.01-1.5wt.%, preferably 0.02-1.0wt.% the component A and 1/2 amount-same amount of normally admired adding amount of ionophores antibiotic to feed of the component B. By said method, using amount of ionophores antibiotic, and also possibility of acquirement of resistance to ionophores, are able to be reduced.

公开(公告)号：JPS5388330A

公开(公告)日：1978-08-03

申请号：JP320277

申请日：1977-01-14

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD ,  NIPPON SEIBUTSU KAGAKU KENKIYU

Inventor： MATSUNO TOSHIMI ,  IMAI KINICHI

IPC: C07D241/18 ,  A61K31/495 ,  A61P33/02 ,  C07D241/26

Abstract: PURPOSE:To provide a low-toxic prophylactic and remedy effective to coccidium in general, containing pirazine carboxylic acid derivative as an effective component.

公开(公告)号：JPS5436292A

公开(公告)日：1979-03-16

申请号：JP10134977

申请日：1977-08-23

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD ,  NIPPON SEIBUTSU KAGAKU KENKIYU

Inventor： MATSUNO TOSHIMI ,  IMAI KINICHI

IPC: C07D473/34 ,  A61K31/52 ,  A61P33/02

Abstract: PURPOSE:An adenine derivative of formula I (R is H, C1-3 alkyl; R is C1-3 alkyl, allyl; R , R are halogen), or its salt.

公开(公告)号：JPS5423133A

公开(公告)日：1979-02-21

申请号：JP8650077

申请日：1977-07-18

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD ,  NIPPON SEIBUTSU KAGAKU KENKIYU

Inventor： MATSUNO TOSHIMI ,  IMAI KINICHI

IPC: A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P33/02 ,  C07H19/04

Abstract: PURPOSE:To provide a prophylactic and remedy for coccidiosis, containing specific pirazine derivative as an effective component.

公开(公告)号：JPS5283801A

公开(公告)日：1977-07-13

申请号：JP123776

申请日：1976-01-01

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： IMADA SATORU ,  NOZAKI YUKIMASA ,  HASEGAWA TOORU ,  MATSUNO TOSHIMI ,  DOUMOTO KENJI

IPC: C12P7/00 ,  A01N63/02 ,  A61K35/74 ,  A61K39/00 ,  A61K45/00 ,  C07G11/00 ,  C12R1/465

Abstract: PURPOSE:A liposoluble polyether antibiotic, having excellent antibacterial action on the various bacteria, especially gram-negative bacteria and acid fast bacteria, and excellent inhibiting action on protozoans such as Eimeria tenella, obtained from an actinomyces belonging to the streptomyces family.

公开(公告)号：JPS5135495A

公开(公告)日：1976-03-25

申请号：JP10728174

申请日：1974-09-17

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： IMADA SATORU ,  NOZAKI YUKIMASA ,  HASEGAWA TOORU ,  MATSUNO TOSHIMI ,  DOMOTO KENJI

IPC: A01N63/02 ,  A61K35/74 ,  A61K39/00 ,  A61K45/00 ,  A61P31/04 ,  C07G11/00 ,  C12P1/06 ,  C12R1/465