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公开(公告)号：US20150081012A1
公开(公告)日：2015-03-19
申请号：US14552261
申请日：2014-11-24
Applicant: The Regents of the University of California
Inventor： Seyedhamed Alavi , Arash Kheradvar
CPC classification number: A61F2/2418 , A61F2/07 , A61F2/2415 , A61F2/90 , A61F2240/001 , A61K35/12 , A61L27/047 , A61L27/34 , A61L27/3804 , A61L27/3808 , A61L27/3826 , A61L27/3886 , A61L27/446 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/18 , A61L2430/20 , C12N5/0068 , C12N5/0691 , C12N2501/15 , C12N2533/10 , C12N2533/54 , C08L89/06
Abstract: A scaffold to form tissue membranes, comprising: at least one layer of mesh having a first side and a second side, the layer of mesh being either a woven wire metal mesh or a flat metal sheet that is acid-etched such that the layer of mesh includes a network of holes passing directly through the mesh from the first side to the second side; and at least one layer of cells at each side of the mesh enclosing the layer of mesh, such that the at least one layer of cells on the first side interacts with the at least one layer of cells on the second side through the network of holes to provide for structure integration.
Abstract translation: 一种用于形成组织膜的支架，包括：具有第一侧和第二侧的至少一层网眼，所述网格层是编织金属丝网或被平均刻蚀的平板金属片，使得该层 网格包括从第一侧到第二侧直接通过网的孔网; 以及围绕所述网格层的所述网的每一侧的至少一层细胞，使得所述第一侧上的所述至少一层细胞与所述第二侧上的所述细胞的所述至少一层通过孔网络相互作用 提供结构整合。
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22.发明授权公开(公告)号：US11990224B2
公开(公告)日：2024-05-21
申请号：US17214442
申请日：2021-03-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Hamid Jafarkhani , Saeed Karimi-Bidhendi , Arash Kheradvar
CPC classification number: G16H30/40 , G06F18/2148 , G06F18/2185 , G06F18/2193 , G06N3/08 , G06N7/01 , G06T7/0012 , G06T7/143 , G06V10/82 , G06T2207/10088 , G06T2207/20084 , G06T2207/30048 , G06V2201/031
Abstract: Methods, devices, and systems that are related to facilitating an automated, fast and accurate model for cardiac image segmentation, particularly for image data of children with complex congenital heart disease are disclosed. In one example aspect, a generative adversarial network is disclosed. The generative adversarial network includes a generator configured to generate synthetic imaging samples associated with a cardiovascular system, and a discriminator configured to receive the synthetic imaging samples from the generator and determine probabilities indicating likelihood of the synthetic imaging samples corresponding to real cardiovascular imaging sample. The discriminator is further configured to provide the probabilities determined by the discriminator to the generator and the discriminator to allow the parameters of the generator and the parameters of the discriminator to be adjusted iteratively until an equilibrium between the generator and the discriminator is established.
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公开(公告)号：US20230263627A1
公开(公告)日：2023-08-24
申请号：US18308239
申请日：2023-04-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar , Daryl C. Nguyen
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2433 , A61F2210/0057
Abstract: A growth-accommodating prosthetic valve system that can accommodate a patient's growth over time. The system features an expandable stent that can expand from a contracted configuration to an expanded configuration and leaflets attached to the scaffold that is sewn along a path such that the length of the path stays generally the same as the scaffold moves from the contracted configuration to the expanded configuration.
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公开(公告)号：US11666444B2
公开(公告)日：2023-06-06
申请号：US16636170
申请日：2018-08-02
Applicant: The Regents of the University of California
Inventor： Arash Kheradvar , Gregory S. Kelley
IPC: A61F2/24
CPC classification number: A61F2/2487 , A61F2/2415 , A61F2/2418 , A61F2210/0014 , A61F2220/0025
Abstract: Described is a collapsible atrial cage for percutaneous delivery and implantation of an atrioventricular valve within an atrium of the heart. The atrial cage includes an atrial portion and a ventricular portion. The ventricular portion is attached with and separated from the atrial portion by a valve juncture portion. Notably, the cage includes at least one interlock shaped to lock with and secure an atrioventricular valve proximate the valve juncture portion. Thus, when deployed and expanded, the atrioventricular valve is secured at the atrioventricular juncture.
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25.发明授权公开(公告)号：US10758347B2
公开(公告)日：2020-09-01
申请号：US15627360
申请日：2017-06-19
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Arash Kheradvar , Gregory S Kelley
Abstract: Described is a delivery system for percutaneous delivery and implantation of a heart valve. The delivery system includes a handle with a sheath extending therefrom. A splay shaft extends from the handle through the sheath. At least two arms extend from the handle through the splay shaft. The at least two arms are operable for holding a heart valve. A sheath controller is housed within the handle and is operable for selectively advancing or retracting the sheath to constrain or expose a heart valve as attached with the at least two arms. A splay shaft controller is housed within the handle for allowing the user to selectively advance or retract the splay shaft to constrain or expose the at least two arms. Finally, a valve release is attached with the handle to allow a user to selectively release a heart valve as attached with the at least two arms.
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Patent Agency Ranking
公开(公告)号：US10345132B2
公开(公告)日：2019-07-09
申请号：US13886680
申请日：2013-05-03
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmad Falahatpisheh , Arash Kheradvar
Abstract: A multi-planar velocimetry approach to characterize 3D incompressible flows based on 2D perpendicular (or otherwise complementary) velocity fields is described. Two-dimensional velocity fields acquired on the planes are reconstructed into a 3D velocity field through interpolation and the imposition of a fluid incompressibility constraint.
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公开(公告)号：US20190151509A1
公开(公告)日：2019-05-23
申请号：US16198116
申请日：2018-11-21
Applicant: The Regents of the University of California
Inventor： Arash Kheradvar , Ramin Zareian
CPC classification number: A61L27/3808 , A61F2/2415 , A61L27/06 , A61L27/18 , A61L27/34 , A61L27/3604 , A61L27/3826 , A61L27/507 , A61L2430/20 , C08L75/04 , C08L89/06
Abstract: A hybrid tissue engineered heart valve leaflet including a polyurethane core, such as a polycarbonate-based thermoplastic polyurethane like carbothane. The polyurethane core is enclosed within one or more layer of a patient's cells and collagen. Also disclosed are hybrid tissue engineered heart valves, including a frame; and at least two leaflets attached thereto in a configuration of a heart valve, wherein the leaflets are hybrid tissue engineered heart valve leaflets, and methods of making a hybrid tissue engineered heart valve for deployment in a patient.
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公开(公告)号：US10134127B2
公开(公告)日：2018-11-20
申请号：US15102853
申请日：2014-12-10
Applicant: The Regents of the University of California
Inventor： Ahmad Falahatpisheh , Arash Kheradvar
Abstract: A method for generating fluid flow images of a region of interest is disclosed. The method includes: scanning the region of interest to acquire a set of 4D-Flow magnetic resonance images, wherein the set comprises an anatomical magnitude image, a first velocity component image, a second velocity component image, and a third velocity component image; isolating the anatomical magnitude image, the first velocity component image, the second velocity component image, and the third velocity component image from the set of 4D-Flow magnetic resonance images; converting the first, second, and third velocity component images into a velocity vector field; modeling a location of an anatomical wall within the region of interest; calculating at least one flow dynamics parameter for the region of interest; and generating a visual representation of the anatomical wall and the at least one flow dynamics parameter.
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公开(公告)号：US20180253854A1
公开(公告)日：2018-09-06
申请号：US15973321
申请日：2018-05-07
Applicant: The Regents of the University of California
Inventor： Ahmad Falahatpisheh , Arash Kheradvar
CPC classification number: G06T7/20 , A61B8/06 , A61B8/065 , A61B8/463 , A61B8/466 , A61B8/483 , A61B8/488 , A61B8/5223 , G06K9/00577 , G06K9/4604 , G06K9/4661 , G06T7/0012 , G06T2200/04 , G06T2207/10136 , G06T2207/30104
Abstract: The disclosure relates to method of processing three-dimensional images or volumetric datasets to determine a configuration of a medium or a rate of a change of the medium, wherein the method includes tracking changes of a field related to the medium to obtain a deformation or velocity field in three dimensions. In some cases, the field is a brightness field inherent to the medium or its motion. In other embodiments, the brightness field is from a tracking agent that includes floating particles detectable in the medium during flow of the medium.
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公开(公告)号：US09968445B2
公开(公告)日：2018-05-15
申请号：US14898048
申请日：2014-06-13
Applicant: The Regents of the University of California
Inventor： Arash Kheradvar
CPC classification number: A61F2/2412 , A61B90/37 , A61B2090/3782 , A61F2/2418 , A61F2230/0095
Abstract: Described is a transcatheter mitral valve. The mitral valve includes a saddle-shaped annulus frame with two prongs extending therefrom. Two leaflets are attached with the frame and prongs to form a bi-leaflet mitral valve. The frame is collapsible to a collapsed configuration that allows for delivery and implantation at a mitral position. When at the mitral position, the mitral valve expands into an open configuration and is secured in place by a fixture, such as clamps that extend from the frame.
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