公开(公告)号：US10004737B2

公开(公告)日：2018-06-26

申请号：US15039092

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Julien Alistair Brown ,  Mark Daniel Calmiano ,  Elizabeth Pearl Jones ,  Boris Kroeplien ,  James Thomas Reuberson ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Zhaoning Zhu

IPC: A61K31/506 ,  A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/4985 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K45/06

Abstract: A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5-α]pyridine derivatives, and analogs thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20180134728A1

公开(公告)日：2018-05-17

申请号：US15580059

申请日：2016-06-07

Applicant: UCB Biopharma SPRL

Inventor： Gareth Neil Brace ,  Prafulkumar Tulshibhai Chovatia ,  Gregory Foulkes ,  James Andrew Johnson ,  Severine Danielle Jones ,  Boris Kroeplien ,  Fabien Claude Lecomte ,  Pui Leng Loke ,  Martin Alexander Lowe ,  Ajay Mandal ,  Timothy John Norman ,  Christopher Francis Palmer ,  Yolanda Pérez-Fuertes ,  John Robert Porter ,  Donald Smyth ,  Giancarlo Trani ,  Muhammed Uddin ,  Zhaoning Zhu

IPC: C07D498/04 ,  A61P29/00 ,  A61P25/00 ,  A61P3/00 ,  A61P27/02 ,  A61P23/00 ,  A61P9/00 ,  A61P35/00 ,  A61K31/5383 ,  C07D413/14 ,  A61K31/538 ,  C07D413/06 ,  C07D471/04 ,  C07D413/12 ,  A61K31/473 ,  A61K31/4375 ,  A61K31/4725 ,  A61K31/444 ,  A61K31/423 ,  A61K31/4545 ,  A61K31/55 ,  C07D519/00

CPC classification number: C07D498/04 ,  A61K31/423 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/473 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/55 ,  A61P3/00 ,  A61P9/00 ,  A61P23/00 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  C07D401/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D519/00

Abstract: A series of substituted 3,4-di-hydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20170128445A1

公开(公告)日：2017-05-11

申请号：US15039092

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Julien Alistair Brown ,  Mark Daniel Calmiano ,  Elizabeth Pearl Jones ,  Boris Kroeplien ,  James Thomas Reuberson ,  Matthew Duncan Selby ,  Michael Alan Shaw ,  Zhaoning Zhu

IPC: A61K31/506 ,  A61K31/437 ,  A61K31/444 ,  C07D487/04 ,  A61K31/5377 ,  C07D471/04 ,  C07D519/00

CPC classification number: A61K31/506 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K2300/00

Abstract: A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5-α]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20160304470A1

公开(公告)日：2016-10-20

申请号：US15101283

申请日：2014-12-08

Applicant: UCB BIOPHARMA SPRL

Inventor： Rikki Peter Alexander ,  Gregory Foulkes ,  Martin Clive Hutchings ,  Victoria Elizabeth Jackson ,  Boris Kroeplien ,  James Thomas Reuberson ,  Sarah Margaret Rook ,  Zhaoning Zhu

IPC: C07D239/74 ,  C07D215/14 ,  A61K31/47 ,  C07D241/42 ,  A61K31/472 ,  C07D237/28 ,  A61K31/502 ,  C07D403/04 ,  A61K31/506 ,  C07D217/16 ,  A61K31/517 ,  A61K31/498

CPC classification number: C07D239/74 ,  A61K31/47 ,  A61K31/472 ,  A61K31/498 ,  A61K31/502 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  C07D215/06 ,  C07D215/14 ,  C07D217/16 ,  C07D237/28 ,  C07D237/32 ,  C07D241/42 ,  C07D241/44 ,  C07D403/04 ,  A61K2300/00

Abstract: A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract translation: 因此，含有两个融合的六元环的一系列取代的杂芳族化合物（tivity）在治疗和/或预防各种人类疾病中有益，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。

公开(公告)号：US20150191482A1

公开(公告)日：2015-07-09

申请号：US14414299

申请日：2013-07-05

Applicant: UCB Biopharma SPRL

Inventor： Jonathan Mark Bentley ,  Daniel Christopher Brookings ,  Julien Alistair Brown ,  Thomas Paul Cain ,  Laura Jane Gleave ,  Alexander Heifetz ,  Victoria Elizabeth Jackson ,  Craig Johnstone ,  Deborah Leigh ,  James Madden ,  John Robert Porter ,  Matthew Duncan Selby ,  Zhaoning Zhu

IPC: C07D491/107 ,  A61K31/5377 ,  C07D451/02 ,  A61K31/506 ,  C07D487/04 ,  C07D471/08 ,  A61K31/5513 ,  A61K31/4985

CPC classification number: C07D491/107 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5513 ,  C07D451/02 ,  C07D471/08 ,  C07D487/04

Abstract: A series of imidazo[1,2-α]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorder; and oncological disorders.

Abstract translation: 因此，作为人TNFα活性的有效调节剂的一系列咪唑并[1,2-α]吡嗪衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病 和肿瘤疾病。