公开(公告)号：EP3965833A1

公开(公告)日：2022-03-16

申请号：EP20802974.4

申请日：2020-05-06

Applicant: University Health Network

Inventor： ZHENG, Gang ,  CHEN, Juan ,  HOU, Wenxiu ,  BU, Jiachuan

IPC: A61K49/00 ,  A61K31/337 ,  A61K41/00 ,  A61K47/44 ,  A61K9/107 ,  A61K9/14 ,  C07D305/14 ,  C07D487/22

公开(公告)号：EP3283493B1

公开(公告)日：2020-11-18

申请号：EP16779355.3

申请日：2016-04-14

Applicant: University Health Network (UHN)

Inventor： ZHENG, Gang ,  KECA, Joseph

IPC: C07F9/10 ,  A61K41/00 ,  A61K49/22 ,  A61K49/10 ,  A61K9/14 ,  A61K9/51 ,  C07D487/22 ,  C07F9/6561 ,  C12P17/18

公开(公告)号：EP2229411B1

公开(公告)日：2019-02-27

申请号：EP08859772.9

申请日：2008-12-12

Applicant: University Health Network

Inventor： ZHENG, Gang ,  ZHANG, Zhihong ,  CORBIN, Ian ,  CHEN, Juan

IPC: C07K17/02 ,  A61K48/00 ,  A61K49/00 ,  A61K51/04 ,  A61P35/00 ,  C12N15/10 ,  C12N15/11 ,  G01N33/566 ,  G01N33/574 ,  C07K14/485 ,  C07K14/71 ,  C12N15/87 ,  A61K47/62

公开(公告)号：EP2788508A1

公开(公告)日：2014-10-15

申请号：EP12855406.0

申请日：2012-12-05

Applicant: University Health Network

Inventor： ZHENG, Gang ,  LOVELL, Jonathan ,  HUYNH, Elizabeth

IPC: C12Q1/68 ,  B01J13/02 ,  C12N11/04 ,  C12P1/00 ,  C12Q1/00 ,  C12N15/88

CPC classification number: C12Q1/6806 ,  A61K41/0028 ,  B01J13/02 ,  C12N11/04 ,  C12N13/00 ,  C12N15/88 ,  C12P1/00 ,  G01N1/28 ,  Y10T436/143333

Abstract: There is provided herein vesicles comprising a bilayer comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipids, wherein the vesicle is 1-100 microns in diameter.

公开(公告)号：EP2717857A1

公开(公告)日：2014-04-16

申请号：EP12796842.8

申请日：2012-05-25

Applicant: University Health Network (UHN)

Inventor： ZHENG, Gang ,  LOVELL, Jonathan

IPC: A61K9/127 ,  A61K31/704 ,  A61K47/22 ,  A61K49/00 ,  A61K51/12 ,  A61K9/14 ,  B01J13/02 ,  C12P17/18 ,  C12P41/00 ,  C07F9/6561

CPC classification number: C12P17/182 ,  A61K8/14 ,  A61K8/553 ,  A61K31/704 ,  A61K41/0071 ,  A61K47/544 ,  A61K2800/10 ,  A61Q19/00 ,  B01J13/02 ,  C07F9/106 ,  C07F9/6561 ,  C09B67/0097 ,  C09B69/108

Abstract: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.