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    COMPOSITE MATERIAL AND ARTIFICIAL BAIT
    21.
    发明申请
    COMPOSITE MATERIAL AND ARTIFICIAL BAIT 审中-公开
    复合材料和人造品

    公开(公告)号：WO1987007476A1

    公开(公告)日：1987-12-17

    申请号：PCT/US1987001307

    申请日：1987-06-10

    Applicant: UNIVERSITY OF FLORIDA

    Inventor： UNIVERSITY OF FLORIDA ,  CARR, William, E., S. ,  BEATTY, Charles, L.

    IPC: A01K97/04

    CPC classification number: A01K85/01 ,  A01K97/045

    Abstract: A composite artificial bait material comprising a foamed plastic (12) attached to a coating (10) containing an attractant for fish, the foamed plastic (12) being insoluble in but rendered soft when immersed in water and the coating (10) comprising a suspension of the attractant in a hydrophilic, water-insoluble matrix which releases the attractant upon immersion upon water.

    Abstract translation: 一种复合人造诱饵材料，包括附着到含有鱼引诱剂的涂层（10）上的泡沫塑料（12），所述发泡塑料（12）浸入水中时不溶于柔软，所述涂层（10）包含悬浮液 的引诱剂在亲水性，水不溶性基质中，浸入水中时释放引诱剂。

    ANTICHOLINERGIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT
    22.
    发明申请
    ANTICHOLINERGIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATMENT 审中-公开
    抗生素化合物，药物组合物和治疗方法

    公开(公告)号：WO1987005603A1

    公开(公告)日：1987-09-24

    申请号：PCT/US1987000533

    申请日：1987-03-17

    Applicant: UNIVERSITY OF FLORIDA ,  HAMMER, Richard, H. ,  BODOR, Nicholas, S.

    Inventor： UNIVERSITY OF FLORIDA

    IPC: C07D451/10

    CPC classification number: C07D451/10

    Abstract: A compound having formula (I), wherein R is the esterification residue of an alcohol (R -OH) having from 1 to 8 carbon atoms; R is a substituted or unsubstituted aryl, cycloalkyl or alkyl group having from 1 to 8 carbon atoms; R is H or R ; n is an integer from 0 to 4; X is (II), (III), (IV), (V), (VI), (VII) or (VIII); m is an integer from 0 to 4; R is an 8-aza-bicyclo[3.2.1]octane residue or its 6,7-epoxy derivative, (IX) or (X), ortho, meta- or para- substituted alkyl pyridine, (XI) or (XII). The esters are prepared in two steps to the tertiary compounds and in three steps to the quaternary compounds from the phenylmalonic acid. Provided are anticholinergic compounds which exhibit anticholinergic properties and which induce mydriasis as well as pharmaceutical compositions and methods of treatment embodying those compounds which are more effective and less toxic than those presently available.

    Abstract translation: 具有式（I）的化合物，其中R 1是具有1至8个碳原子的醇（R 1 -OH）的酯化残基; R 2是具有1至8个碳原子的取代或未取代的芳基，环烷基或烷基; R 3是H或R 2; n为0〜4的整数; X为（II），（III），（IV），（V），（VI），（VII）或（VIII） m为0〜4的整数; R 4是8-氮杂 - 双环[3.2.1]辛烷残基或其6,7-环氧衍生物，（IX）或（X），邻，间 - 或对 - 取代的烷基吡啶，（XI）或 （XII）。 所述酯分两步制备为叔化合物，并在三个步骤中由苯基丙二酸制备季铵化合物。 提供了抗胆碱能化合物，其表现出抗胆碱能性并且诱导瞳孔散化以及药物组合物和治疗方法，其包含比目前可获得的化合物更有效和毒性更低的那些化合物。

    METHODS AND COMPOSITIONS TO CONTROL TEPHRITIDAE FRUIT FLIES
    23.
    发明申请
    METHODS AND COMPOSITIONS TO CONTROL TEPHRITIDAE FRUIT FLIES 审中-公开
    控制水果的方法和组合物

    公开(公告)号：WO1999013724A1

    公开(公告)日：1999-03-25

    申请号：PCT/US1997016475

    申请日：1997-09-16

    Applicant: UNIVERSITY OF FLORIDA

    Inventor： UNIVERSITY OF FLORIDA ,  NIGG, Herbert, N.

    IPC: A01N59/14

    CPC classification number: A01N25/006 ,  A01N59/14

    Abstract: Methods and compositions, which rely upon borax toxicants, to control Tephritidae fruit fly populations below economic thresholds are disclosed. More particularly, methods and compositions which utilize borax toxicants are disclosed which cause the Tephritidae fruit flies to die prematurely or which interfere with the female Tephritidae fruit flies to produce eggs for a period of about seven days. A preferred borax toxicant is borax wherein an effective amount in the compositions to accomplish the above is between at least about 0.01M and about 0.12M or more. A lethal amount of borax that should be consumed by the fruit flies in about a 24 hour period is believed to be between at least about 5mM and about 10mM or more, whereas the amount of borax that should be consumed by the female fruit flies within about a 24 hour period to prevent the female fruit flies from producing eggs for about seven days or longer is believed to be at least about 2.5mM and 5mM or more.

    Abstract translation: 公开了依赖硼砂有毒物质控制Tephritidae果蝇种群低于经济阈值的方法和组合物。 更具体地，公开了利用硼砂毒物的方法和组合物，其使得Tephritidae果蝇过早死亡或干扰雌性Tephritidae果蝇以产生约七天的时间。 优选的硼砂毒性剂是硼砂，其中实现上述组合物中的有效量为至少约0.01M至约0.12M或更大。 在大约24小时内，果蝇应该消耗的致死量的硼砂被认为在至少约5mM至约10mM或更多之间，而女性果实应消耗的硼砂的量在约 一个24小时的时间段，以防止女性果蝇产卵大约七天或更长时间被认为是至少约2.5mM和5mM或更多。

    IL-10 AND TGF-BETA FOR TREATING AUTOIMMUNE DISEASE
    24.
    发明申请
    IL-10 AND TGF-BETA FOR TREATING AUTOIMMUNE DISEASE 审中-公开
    用于治疗自身免疫疾病的IL-10和TGF-β

    公开(公告)号：WO1998024469A1

    公开(公告)日：1998-06-11

    申请号：PCT/US1997022221

    申请日：1997-12-05

    Applicant: UNIVERSITY OF FLORIDA

    Inventor： UNIVERSITY OF FLORIDA ,  JOHNSON, Howard, M. ,  MUJTABA, Mustafa, G. ,  SOOS, Jeanne, M.

    IPC: A61K38/20

    CPC classification number: A61K38/2066 ,  A61K38/21 ,  A61K2300/00

    Abstract: The subject invention pertains to novel methods for treating autoimmune-related diseases, such as Multiple Sclerosis (MS). One embodiment of the method of the invention comprises administering interleukin-10 (IL-10) and transforming growth factor-beta (TGF- beta ), in combination, to a person afflicted with or predisposed to an autoimmune disease. When administered in combination, these cytokines act in a synergistic manner as suppressor factors to inhibit the activation of self-reactive T cells that are involved in autoimmune disease.

    Abstract translation: 本发明涉及用于治疗自身免疫相关疾病（例如多发性硬化症（MS））的新方法。 本发明方法的一个实施方案包括将白细胞介素-10（IL-10）和转化生长因子-β（TGF-β）组合施用于患有或易患自身免疫性疾病的人。 当组合施用时，这些细胞因子以协同的方式作为抑制因子来抑制参与自身免疫疾病的自身反应性T细胞的活化。

    MATERIALS AND METHODS FOR DETECTING OXALATE
    27.
    发明申请
    MATERIALS AND METHODS FOR DETECTING OXALATE 审中-公开
    用于检测氧化物的材料和方法

    公开(公告)号：WO1997045552A1

    公开(公告)日：1997-12-04

    申请号：PCT/US1997009019

    申请日：1997-05-30

    Applicant: UNIVERSITY OF FLORIDA

    Inventor： UNIVERSITY OF FLORIDA ,  MANS, Rusty, Jay ,  BATICH, Christopher, D. ,  McFETRIDGE, Ian

    IPC: C12Q01/26

    CPC classification number: C12N9/0008 ,  C12Q1/26 ,  C12Q1/28 ,  Y10S435/814

    Abstract: The subject invention pertains to a novel assay device for detecting oxalate in a sample. The assay device comprises enzyme and dye compositions immobilized on a solid carrier matrix. The subject invention can also be used to measure the concentration of oxalate in a sample. The subject invention further pertains to a novel oxalate oxidase composition and methods of preparing the subject enzyme composition. The oxalate oxidase composition can be used in the assay device of the subject invention.

    Abstract translation: 本发明涉及用于检测样品中草酸盐的新型测定装置。 测定装置包括固定在固体载体基质上的酶和染料组合物。 本发明还可以用于测量样品中草酸盐的浓度。 本发明进一步涉及新型草酸氧化酶组合物和制备本发明酶组合物的方法。 草酸氧化酶组合物可用于本发明的测定装置中。

    MULTI-SUBTYPE FIV VACCINES
    28.
    发明申请
    MULTI-SUBTYPE FIV VACCINES 审中-公开
    多亚型FIV疫苗

    公开(公告)号：WO1997007817A1

    公开(公告)日：1997-03-06

    申请号：PCT/US1996013580

    申请日：1996-08-23

    Applicant: UNIVERSITY OF FLORIDA ,  REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  YAMAMOTO, Janet, K.

    Inventor： UNIVERSITY OF FLORIDA ,  REGENTS OF THE UNIVERSITY OF CALIFORNIA

    IPC: A61K39/21

    CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/515 ,  A61K2039/5156 ,  A61K2039/5252 ,  A61K2039/552 ,  C07K16/1045 ,  C07K2319/40 ,  C12N2740/15034 ,  G01N33/56966 ,  G01N33/56983 ,  G01N33/56988 ,  G01N2333/155

    Abstract: The subject invention pertains to novel methods and compositions for protecting cats from infection by a broad range of FIV strains using a multi-subtype FIV vaccine. Multi-subtype FIV vaccines comprising either cell free whole virus or cell lines infected with viruses are described. Methods for vaccinating cats with the subject vaccine compositions are also described. Cats vaccinated according to the methods and compositions of the subject invention exhibit protective humoral and cellular immune responses to FIV when challenged with homologous or heterologous strains of FIV. The subject invention also pertains to novel feline cell lines that are susceptible to infection by FIV and their methods of use.

    Abstract translation: 本发明涉及使用多亚型FIV疫苗来保护猫免受广泛范围的FIV毒株感染的新方法和组合物。 描述了包含无细胞全病毒或感染病毒的细胞系的多亚型FIV疫苗。 还描述了用本发明疫苗组合物接种猫的方法。 根据本发明的方法和组合物接种的猫在用同源或异源FIV毒株攻击时表现出对FIV的保护性体液和细胞免疫应答。 本发明还涉及易受FIV感染的新型猫科动物细胞系及其使用方法。

    OPTICAL FIBER CATHETER AND METHOD
    29.
    发明申请
    OPTICAL FIBER CATHETER AND METHOD 审中-公开
    光纤导管和方法

    公开(公告)号：WO1996039963A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996008958

    申请日：1996-06-07

    Applicant: ABELA LASER SYSTEMS, INC. ,  UNIVERSITY OF FLORIDA

    Inventor： ABELA LASER SYSTEMS, INC. ,  UNIVERSITY OF FLORIDA ,  ABELA, George, S. ,  FRIEDL, Stephan, E. ,  MATHEWS, Eric, D.

    IPC: A61B17/36

    CPC classification number: A61B18/24 ,  A61B2017/00026 ,  A61B2017/00243 ,  A61B2018/00196

    Abstract: A catheter uses a steerable outer catheter with an inner catheter (14) rotatable and extendable with respect to the outer catheter (12). The outer catheter (12) may be positioned within a patient's heart and a portion of the outer catheter (12) may provide movement like that of a windshield wiper by manipulation of a spring (40). By combining the windshield wiper-type movement with the extension and rotation of the inner catheter (14) relative to the outer catheter (12), a large area within a patient's heart may be readily mapped for conduction tissue and be subjected to laser ablation if appropriate. Various configurations provide flexibility in relatively positioning of windows (16) used to apply laser energy and ring electrodes used to sense conduction tissue. Some embodiments provide only laser ablation (no mapping).

    Abstract translation: 导管使用具有可相对于外导管（12）旋转和延伸的内导管（14）的可操纵外导管。 外导管（12）可以定位在患者的心脏内，并且外导管（12）的一部分可以通过操纵弹簧（40）来提供类似于挡风玻璃刮水器的运动。 通过将挡风玻璃刮水器运动与内导管（14）相对于外导管（12）的延伸和旋转相结合，患者心脏内的大面积可以容易地映射为传导组织，并且如果 适当。 各种配置在用于施加用于感测传导组织的激光能量和环形电极的窗口（16）的相对定位中提供灵活性。 一些实施例仅提供激光烧蚀（无映射）。

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