公开(公告)号：KR1020020089304A

公开(公告)日：2002-11-29

申请号：KR1020027006232

申请日：2000-11-15

Applicant: (주)다이아칩

Inventor： 김선영 ,  박은진 ,  나영순 ,  유승신

IPC: C12Q1/70

CPC classification number: C07K16/1036

Abstract: PURPOSE: Provided is a method for detecting replication competent viruses in the sera of subjects receiving gene therapy. CONSTITUTION: In the method for detecting a replication competent virus in a subject receiving gene therapy using a viral vector, it comprises the steps of: reacting the subject's serum with an antigen protein encoded by a gene that is not present in the viral vector but present in the genome of the virus from which the viral vector is derived ; and measuring the antibody protein in the subject's serum, wherein the viral vector is derived from a retrovirus, an Adenovirus, an adeno-associated virus or a lentivirus; and the antigen protein is a portion of Gag or Env protein of murine leukemia virus(wherein, the portion of Gag protein of murine leukemia virus has the amino acid sequence of SEQ ID NO:2, and the portion of Env protein of murine leukemia virus has the amino acid sequence of SEQ ID NO:6).

Abstract translation: 目的：提供一种检测接受基因治疗的受试者血清中复制型病毒的方法。 构成：在使用病毒载体接受基因治疗的受试者检测可复制感染性病毒的方法中，其包括以下步骤：使受试者的血清与由病毒载体中不存在的但不存在的基因编码的抗原蛋白质反应 在病毒载体衍生的病毒的基因组中; 并测量受试者血清中的抗体蛋白质，其中病毒载体衍生自逆转录病毒，腺病毒，腺相关病毒或慢病毒; 抗原蛋白是鼠白血病病毒的Gag或Env蛋白质的一部分（其中，鼠白血病病毒的Gag蛋白的部分具有SEQ ID NO：2的氨基酸序列，小鼠白血病病毒的Env蛋白部分 具有SEQ ID NO：6的氨基酸序列）。

公开(公告)号：KR1020000071901A

公开(公告)日：2000-12-05

申请号：KR1019990050510

申请日：1999-11-15

Applicant: 김선영

Inventor： 박은진 ,  나영순 ,  유승신 ,  김선영

IPC: C12Q1/70 ,  G06F19/20

CPC classification number: C07K16/1036

Abstract: PURPOSE: A diagnosis kit against antibody replication competent virus(RCV) for gene therapy is provided. Thereby, RCV(replication competent virus) production in vivo is confirmed correctly and easily. CONSTITUTION: An analysis method of replication competent virus(RCV) is characterized by comprising the following steps: (i)preparing specimen from animal and human body undergoing gene therapy with viral vector; (ii)qualitative analyzing or quantitative analyzing an antibody for an antigen protein derived from virus genome, which is contained in the viral vector. The qualitative or the quantitative analysis method of RCV is characterized by using ELISA(enzyme linked immunosorbent assay) or FLISA(fluorescence linked immunosorbent assay) method. The antigen protein of RCV analysis method is fixed on biological microchip using 50% of ethanol.

Abstract translation: 目的：提供抗病毒复制合成病毒（RCV）用于基因治疗的诊断试剂盒。 由此，能够正确容易地确认体内RCV（复制型病毒）的生成。 构成：复制合格病毒（RCV）的分析方法的特征在于包括以下步骤：（i）用病毒载体进行基因治疗的动物和人体制备标本; （ii）定性分析或定量分析病毒载体中包含的源自病毒基因组的抗原蛋白的抗体。 RCV的定性或定量分析方法的特点是使用ELISA（酶联免疫吸附测定法）或FLISA（荧光联合免疫吸附测定法）。 使用50％乙醇将RCV分析方法的抗原蛋白固定在生物微芯片上。

公开(公告)号：US10059758B2

公开(公告)日：2018-08-28

申请号：US15794541

申请日：2017-10-26

Applicant: GENEURO SA

Inventor： Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

IPC: A61K39/395 ,  C07K16/10 ,  A61K39/00

CPC classification number: C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: A ligand includes each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or any sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1 (SEQ ID No.1), from 0 to 2 in CDR2 (SEQ ID No.2), from 0 to 2 in CDR3 (SEQ ID No.3), from 0 to 1 in CDR4 (SEQ ID No.4), from 0 to 4 in CDR5 (SEQ ID No.5), from 0 to 2 in CDR6 (SEQ ID No.6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

公开(公告)号：US20180208663A1

公开(公告)日：2018-07-26

申请号：US15922921

申请日：2018-03-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I WANG ,  Peter BRAUER ,  Siok Ping YEO ,  Hwee Ching TAN ,  John Edward CONNOLLY

IPC: C07K16/28 ,  A61K47/68

CPC classification number: C07K16/2866 ,  A61K38/1709 ,  A61K39/3955 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/57 ,  C07K16/1036 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

公开(公告)号：US20180195137A1

公开(公告)日：2018-07-12

申请号：US15580042

申请日：2016-06-08

Applicant: Swansea University

Inventor： Paul Dyson ,  Miranda Whitten

IPC: C12R1/01 ,  C12N15/113 ,  C07K16/10 ,  A01N63/02 ,  A01N37/46 ,  C12N15/74 ,  A01N25/00

CPC classification number: C12R1/01 ,  A01N25/006 ,  A01N37/46 ,  A01N63/00 ,  A01N63/02 ,  C07K16/1036 ,  C12N15/113 ,  C12N15/746 ,  C12N2310/14

Abstract: The invention relates to a genetically transformed or transfected bacterial cell of a gut symbiont of an insect belonging to the Order Thysanoptera wherein said cell is transformed to express double-stranded RNA (dsRNA) active against at least one selected insect gene; a vector for transforming or transfecting said bacterial cell; an insect including said transformed bacterial cell and a method of pest control employing the use of said bacterial cell and/or said insect.

公开(公告)号：US20170334952A1

公开(公告)日：2017-11-23

申请号：US15495627

申请日：2017-04-24

Applicant: Rutgers, The State University of New Jersey

Inventor： Vincent K. Tsiagbe ,  Yu Li

IPC: C07K14/15 ,  C12Q1/68 ,  C07K16/10 ,  G01N33/574 ,  C12Q1/70 ,  A61K38/00

CPC classification number: C07K14/15 ,  A61K38/00 ,  C07K7/08 ,  C07K14/005 ,  C07K16/1036 ,  C07K16/1063 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/55 ,  C12N2710/14143 ,  C12N2740/10022 ,  C12N2740/13022 ,  C12Q1/68 ,  C12Q1/702 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57426 ,  G01N2333/15

Abstract: The present invention relates to methods and kits for diagnosis of cancer in a subject by detecting human endogenous retrovirus env (HERV-WL) polypeptides.

公开(公告)号：US20140302040A2

公开(公告)日：2014-10-09

申请号：US13894865

申请日：2013-05-15

Applicant: Daiichi Sankyo Company, Limited

Inventor： Satomichi Yoshimura ,  Tatsuya Kurihara ,  Kayoko Kawashima ,  Masato Hoshino ,  Kumiko Kadoshima ,  Maki Tsujimoto ,  Takako Kimura ,  Jun Hasegawa

IPC: C07K16/10 ,  A61K45/06 ,  A61K39/42 ,  G01N33/68

CPC classification number: C07K16/1036 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/564 ,  G01N33/6893

Abstract: The present invention provides an antibody that recognizes a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 15 in the Sequence Listing and has an anti-arthritic function, or a functional fragment thereof.

公开(公告)号：US20130040369A1

公开(公告)日：2013-02-14

申请号：US13551286

申请日：2012-07-17

Applicant: Robert H. Silverman ,  Eric A. Klein ,  Graham Casey ,  Joseph DeRisi ,  Don Ganem

Inventor： Robert H. Silverman ,  Eric A. Klein ,  Graham Casey ,  Joseph DeRisi ,  Don Ganem

IPC: C12N7/00 ,  C07K14/15

CPC classification number: C12N7/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1036 ,  C12N9/22 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12Q1/6886 ,  C12Q1/70 ,  C12Q1/701 ,  C12Q2600/136

Abstract: The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.

Abstract translation: 本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

公开(公告)号：US08183349B2

公开(公告)日：2012-05-22

申请号：US12828161

申请日：2010-06-30

Applicant: Xiaoxing Qiu ,  John R. Hackett, Jr. ,  Ka-Cheung X. Luk ,  Priscilla Swanson

Inventor： Xiaoxing Qiu ,  John R. Hackett, Jr. ,  Ka-Cheung X. Luk ,  Priscilla Swanson

IPC: C07K16/18

CPC classification number: C07K16/1036 ,  A61K39/00 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2740/13022

Abstract: The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities.

Abstract translation: 本发明一般涉及用于检测嗜酸性白血病病毒相关逆转录病毒（“XMRV”）和与XMRV感染有关的疾病的检测方法。 此外，本发明涉及能够诱导免疫原性应答的特异性XMRV抗原以及具有显着诊断，筛选和治疗效用的XMRV相关核酸。

公开(公告)号：US08133727B2

公开(公告)日：2012-03-13

申请号：US12622379

申请日：2009-11-19

Applicant: Xin Luo ,  Lili Yang ,  David Baltimore

Inventor： Xin Luo ,  Lili Yang ,  David Baltimore

IPC: C12N5/08 ,  C12N5/00 ,  C12N5/02

CPC classification number: C12N5/0635 ,  C07K16/00 ,  C07K16/1036 ,  C07K16/1045 ,  C12N2501/056 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2501/52 ,  C12N2502/1394 ,  C12N2510/02

Abstract: The present disclosure relates to systems, methods and compositions for the generation of antibody-producing B cells in vitro. Some embodiments are related to an in vitro system for generating antibody-producing B cells from hematopoietic stem/progenitor cells (HSPCs).

Abstract translation: 本公开涉及用于在体外产生产生抗体的B细胞的系统，方法和组合物。 一些实施方案涉及用于从造血干细胞/祖细胞（HSPC）产生产生抗体的B细胞的体外系统。