公开(公告)号：US07589329B1

公开(公告)日：2009-09-15

申请号：US12108446

申请日：2008-04-23

Applicant: Daniel W. Youngner

Inventor： Daniel W. Youngner

IPC: G01N21/64

CPC classification number: G01L9/002 ,  G01N2201/06193

Abstract: An optical-based sensor system that detects emitted light. An exemplary embodiment of an optical-based sensor has a substrate with a surface and an internal region; a shell disposed above the substrate surface, the shell operable to receive incident light characterized by a first wavelength; a beam disposed below the shell; a photodiode on the substrate surface below the beam, and in response to receiving a first portion of the incident light, the photodiode is operable to generate a charge such that a motion is induced to resonate at a resonate frequency; and a phosphor in the substrate internal region and operable to receive a second portion of the incident light, the phosphor further operable to emit light characterized by at least one second wavelength that is different from the first wavelength of the incident light, the phosphor emitted light transmitted through the photodiode, the beam, and the shell.

Abstract translation: 一种检测发射光的光学传感器系统。 光学传感器的示例性实施例具有具有表面和内部区域的基板; 壳体，其设置在所述衬底表面上方，所述壳体可操作以接收以第一波长为特征的入射光; 设置在壳体下方的梁; 在光束下面的衬底表面上的光电二极管，并且响应于接收到入射光的第一部分，光电二极管可操作地产生电荷，使得运动被感应为谐振频率谐振; 以及在所述基板内部区域中的荧光体，并且可操作以接收所述入射光的第二部分，所述荧光体还可操作以发射特征在于与所述入射光的第一波长不同的至少一个第二波长的光，所述荧光体发射光 透过光电二极管，光束和外壳。

公开(公告)号：US20070281322A1

公开(公告)日：2007-12-06

申请号：US11805185

申请日：2007-05-21

Applicant: Claudia Jaffe ,  Steven Jaffe ,  Michieal Jones

Inventor： Claudia Jaffe ,  Steven Jaffe ,  Michieal Jones

IPC: G01N33/53 ,  G01J3/427

CPC classification number: G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

Abstract translation: 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。

公开(公告)号：US20070249917A1

公开(公告)日：2007-10-25

申请号：US11811083

申请日：2007-06-08

Applicant: Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

Inventor： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC: A61B5/00

CPC classification number: A61B5/0066 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/4795 ,  G01N21/6428 ,  G01N2021/1787 ,  G01N2201/06193 ,  Y10S436/805 ,  Y10T436/144444

Abstract: There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and/or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa). As such, some or all (or substantially all) of the receptor molecules within a given layer may bind with the analyte, which results in a change in the optical properties of one or more of the layers. These layer(s) may be examined or interrogated, via optical techniques, whereby the optical response of the layers and/or, in particular, the substance within the layer(s), may be measured, evaluated and/or analyzed.

公开(公告)号：USRE39672E1

公开(公告)日：2007-06-05

申请号：US10056335

申请日：2002-01-23

Applicant: Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

Inventor： Ramez E. N. Shehada ,  Vasilis Z. Marmarelis ,  Warren S. Grundfest

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

Abstract: The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

Abstract translation: 激光诱导荧光衰减光谱法（LIFAS）方法和装置优选地包括适于发射针对样品中的样品体积的辐射以产生来自样品的返回光的源，这种返回光包括由调制的调制的返回光 样品，第一传感器，离开样品体积第一距离，用于监测返回光并产生指示返回光强度的第一信号;第二传感器，其从样品体积中移出第二距离，用于监测 返回光并产生指示返回光强度的第二信号，以及与第一传感器和第二传感器相关联并适于处理第一和第二信号以便确定样本的调制的处理器。 本发明的方法和装置特别适用于确定样品的波长相关衰减，并使用衰减来恢复样品的固有激光诱导荧光。 反过来，衰减和固有的激光诱导荧光可用于确定感兴趣的特征，例如生物组织的缺血或缺氧状况。

公开(公告)号：US5039868A

公开(公告)日：1991-08-13

申请号：US439943

申请日：1989-11-22

Applicant: Shigeki Kobayashi ,  Hideaki Takahara

Inventor： Shigeki Kobayashi ,  Hideaki Takahara

IPC: G01N21/956

CPC classification number: G01N21/95684 ,  G01N2021/6439 ,  G01N2021/8887 ,  G01N2021/95646 ,  G01N2201/06193

Abstract: Disclosed is a substrate inspecting method in which light is projected to a part (21) mounted on a substrate (20) from a ring-shaped light source (29), reflected light form the surface of a soldered portion (44) is imaged by an imaging unit (32) and the nature of the soldered portion is inspected by its imaged pattern, characterized by applying fluorescent agents (70) to at least the periphery of the soldered portion of the mounted part on the surface of the substrate, exposing the surface coated with the fluorescent agents to light from the ring-shaped light source to excite the fluorescent agents, exposing the surface of the soldered portion to secondary illuminating light produced by the fluorescent agents to image its reflected light.

Abstract translation: 公开了一种基板检查方法，其中光从环形光源（29）投射到安装在基板（20）上的部分（21）上，形成焊接部分（44）的表面的反射光通过 成像单元（32）和焊接部分的性质通过其成像图案进行检查，其特征在于将荧光剂（70）至少施加到基板表面上的安装部分的焊接部分的周边， 将荧光剂表面涂覆到来自环形光源的光以激发荧光剂，将焊接部分的表面暴露于由荧光剂产生的二次照明光以对其反射光进行成像。

公开(公告)号：WO2017098223A1

公开(公告)日：2017-06-15

申请号：PCT/GB2016/053823

申请日：2016-12-05

Applicant: BAE SYSTEMS PLC

Inventor： LAYCOCK, Leslie Charles

IPC: G01S7/481 ,  G01S7/497 ,  G01S17/74 ,  G01S17/95 ,  G01N21/63 ,  G02B26/06 ,  G01S7/48

CPC classification number: G01S17/74 ,  G01K11/20 ,  G01N21/63 ,  G01N21/643 ,  G01N21/6489 ,  G01N2021/1793 ,  G01N2201/06193 ,  G01S7/4802 ,  G01S7/481 ,  G01S7/4811 ,  G01S7/497 ,  G01S17/95 ,  G02B26/06 ,  Y02A90/19

Abstract: A system for remotely sensing light from within a monitored environment containing one or more retro-reflective optical elements. The system includes an illuminator including a light source and a reflector unit comprising a deformable mirror arranged to receive light from the light source and to reflect the received light. This outputs illumination light from the illuminator for illuminating the optical element(s) within the monitored environment. A detector is arranged to receive light returned by the one or more retro-reflective optical elements in response to the illumination light. The detector determines a wavefront of the returned light and detects a property of the monitored environment according to the returned light. The reflector unit is arranged to deform the deformable mirror according to the determined wavefront such that light from the light source is reflected by the deformable mirror so deformed to output illumination light with a modified wavefront.

Abstract translation: 用于从包含一个或多个回射光学元件的监视环境内遥测光的系统。 该系统包括照明器，该照明器包括光源和反射器单元，反射器单元包括可变形反射镜，该可变形反射镜被布置成接收来自光源的光并且反射所接收的光。 这输出来自照明器的照明光以照亮被监测环境内的光学元件。 检测器被布置成响应于照明光而接收由一个或多个回射光学元件返回的光。 检测器确定返回的光的波前，并根据返回的光检测所监测的环境的特性。 反射器单元被布置成根据所确定的波前使可变形反射镜变形，使得来自光源的光被变形反射镜反射，从而变形以输出具有修改的波前的照明光。

公开(公告)号：WO2011092259A1

公开(公告)日：2011-08-04

申请号：PCT/EP2011/051168

申请日：2011-01-27

Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  HOENES, Joachim ,  WEHOWSKI, Frederic ,  MISCHLER, Reinhold ,  HARTTIG, Herbert

Inventor： HOENES, Joachim ,  WEHOWSKI, Frederic ,  MISCHLER, Reinhold ,  HARTTIG, Herbert

IPC: G01N21/31 ,  G01N21/86 ,  G01N33/487

CPC classification number: G01N21/3151 ,  G01N21/8483 ,  G01N2021/3155 ,  G01N2201/06193 ,  G01N2201/0696

Abstract: Die Erfindung betrifft ein Messsystem insbesondere zur Blutzuckerbestimmung mit einer photometrischen Messeinheit (16), die eine Lichtquelle (22) und einen Detektor (24) umfasst, und einem mit einer Probe, insbesondere einer Körperflüssigkeit beaufschlagbaren und für einen optischen Nachweis eines Analyten in einen Strahlengang (18) zwischen der Lichtquelle (22) und dem Detektor (24) bringbaren analytischen Testelement (14). Für eine verbesserte Mehrwellenlängenmessung wird vorgeschlagen, dass die Lichtquelle (22) einen in einem ersten Wellenlängenbereich zur Aussendung von pulsierendem Wechsellicht (28) ansteuerbaren ersten Strahler (26) und einen in einem zweiten Wellenlängenbereich zur Emission von Fluoreszenzlicht (32) anregbaren zweiten Strahler (30) aufweist.

Abstract translation: 本发明涉及一种测量系统，特别是用于确定与光度测量单元（16）包括光源（22）和一个检测器（24），并与样品的可加载，特别是体液血糖和用于分析物的中的光束路径的光学检测 （18）能够在光源（22）和检测器（24）的分析测试元件（14）之间被带到。 一种改进的多波长测量建议，所述光源（22）刺激的可控在两个第一波长范围内发射脉动交变光（28）的第一散热器（26）和在第二波长范围内发射光的荧光（32）第二散热器（30 ）了。

公开(公告)号：WO2009076678A1

公开(公告)日：2009-06-18

申请号：PCT/US2008/086886

申请日：2008-12-15

Applicant: BIOVIGILANT SYSTEMS, INC. ,  BINNIE, Erik, H. ,  MORRIS, Gregory, Scott

Inventor： BINNIE, Erik, H. ,  MORRIS, Gregory, Scott

IPC: H01J40/14

CPC classification number: G01N15/1434 ,  G01N1/2247 ,  G01N1/2273 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/6486 ,  G01N2015/0088 ,  G01N2015/025 ,  G01N2015/1486 ,  G01N2015/1493 ,  G01N2201/06113 ,  G01N2201/06193

Abstract: A method and apparatus for detecting pathogens and particles in a fluid in which particle size and intrinsic fluorescence of a simple particle is determined, comprising a sample cell; a light source on one side of the sample cell for sending a focused beam of light through the sample, whereby portions of the beam of light are scattered at various angles by particles of various sizes present in the sample area; a particle size detector positioned in the light path for detecting a portion of forward scattered light; a pair of fluorescence detectors positioned off axis from the beam of light; and a pair of elliptical mirrors positioned such that an intersection of the incoming particle stream and the light beam are at one foci of each ellipsoid, and one of said pair of fluorescence detectors lies at the other foci.

Abstract translation: 一种用于检测流体中病原体和颗粒的方法和装置，其中确定了简单颗粒的粒度和固有荧光，包括样品池; 在样品池的一侧上的光源，用于发射聚焦光束穿过样品，由此部分光束以各种尺寸的颗粒以样品区域中存在的各种尺寸散射; 位于光路中的用于检测前向散射光的一部分的粒度检测器; 位于离光束离轴的一对荧光检测器; 以及一对椭圆镜，其定位成使得进入的粒子流和光束的交点处于每个椭圆体的一个焦点处，并且所述一对荧光检测器中的一个位于另一个焦点。

公开(公告)号：EP3260845A3

公开(公告)日：2018-05-02

申请号：EP17168073.9

申请日：2017-04-25

Applicant: Fujifilm Corporation

Inventor： KOBAYASHI, Takashi

IPC: G01N21/64 ,  G01T1/20 ,  G01N27/447

CPC classification number: G01N21/6456 ,  G01N21/6428 ,  G01N21/6486 ,  G01N27/44717 ,  G01N27/44721 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2201/06193 ,  G01N2201/11

Abstract: There are provided a control device of an image reading apparatus, an operation method and an operation program thereof, and an image detection system capable of quickly and easily outputting an image having an appropriate density for analysis from an image reading apparatus. An image receiving unit (80) receives a pre-image output in pre-scanning performed before main scanning for outputting a main image for analysis in an image reading apparatus (11). A region information receiving unit (81) receives information of a region in the pre-image designated by a user. A calculation unit (83) calculates an appropriate voltage value (HVM) that is a voltage value of the photomultiplier (31) at which a density of the region becomes an appropriate density for analysis. A scanning conditions setting unit (84) sets the appropriate voltage value (HVM) as temporary scanning conditions (76M) of main scanning.

Abstract translation: 提供了图像读取装置的控制装置，其操作方法和操作程序以及图像检测系统，其能够从图像读取装置快速且容易地输出具有适当分辨率的图像。 图像接收单元（80）接收在主扫描之前执行的预扫描中输出的预图像输出，以在图像读取装置（11）中输出用于分析的主图像。 区域信息接收单元（81）接收用户指定的预先图像中的区域的信息。 计算单元（83）计算作为光电倍增管（31）的电压值的适当电压值（HVM），在该电压值处该区域的密度变为用于分析的适当密度。 扫描条件设定部（84）将适当的电压值（HVM）设定为主扫描的临时扫描条件（76M）。

公开(公告)号：EP3224208A1

公开(公告)日：2017-10-04

申请号：EP15863754.6

申请日：2015-11-20

Applicant: Baker Hughes Incorporated

Inventor： FELIPE, Mary, Jane ,  SANDU, Corina ,  FULMER, David, N. ,  GUO, Bing, Bing

IPC: C02F5/00 ,  C02F1/52

CPC classification number: G01N21/64 ,  C02F5/10 ,  C02F2103/023 ,  C02F2103/08 ,  C02F2303/08 ,  C02F2303/22 ,  G01N33/18 ,  G01N33/1826 ,  G01N2201/06193

Abstract: Water-soluble polymers may be added to an aqueous system to inhibit or decrease scale deposition within the aqueous system. In a non-limiting embodiment, the water-soluble polymer(s) may be or include polymaleates, polyacrylates, copolymers thereof, and combinations thereof. The treated aqueous system may include a decreased amount of scale deposition as compared to an otherwise identical aqueous system absent the water-soluble polymer(s).

Abstract translation: 可以将水溶性聚合物加入含水体系中以抑制或减少含水体系内的水垢沉积。 在一个非限制性实施方案中，水溶性聚合物可以是或包括聚马来酸酯，聚丙烯酸酯，其共聚物及其组合。 与没有水溶性聚合物的另外相同的含水体系相比，经处理的含水体系可包括减少的水垢沉积量。