公开(公告)号：EP2856109A2

公开(公告)日：2015-04-08

申请号：EP13838060.5

申请日：2013-01-07

Applicant: CONCORDIA LABORATORIES INC.

Inventor： ROBERTS, Michael, S.

IPC: G01N21/25 ,  A61K41/00

CPC classification number: G01N33/5011 ,  A61K41/00 ,  C12N13/00 ,  C12Q1/22 ,  F21V5/00 ,  F21V5/04 ,  F21V7/00 ,  F21V9/04 ,  F21V13/02 ,  F21V13/14 ,  G01N21/255 ,  G01N2201/061 ,  G01N2201/0633 ,  G01N2201/0686

Abstract: Presently disclosed is a lighting system and methods of using the lighting system for in vitro potency assay for photofrin. The lighting system includes a lamp housing, a first lens, an infrared absorbing filter, an optical filter, and a second lens. The lamp housing includes a lamp and a light-port. In operation, broad spectrum light from the lamp exits the lamp housing by passing through the light-port. The first lens then collimates the broad spectrum light that exits the lamp housing through the light-port. The infrared absorbing filter then passes a first portion of the collimated broad spectrum light to the optical filter and absorbs infrared light of the broad spectrum light. The optical filter then passes a second portion of the collimated broad spectrum light to the second lens. The second lens then disperses the second portion of the collimated light to provide uniform irradiation of a cell culture plate. A method of using the lighting system for studying a photosensitizer is also disclosed.

公开(公告)号：EP2818846A1

公开(公告)日：2014-12-31

申请号：EP12869106.0

申请日：2012-11-30

Applicant: Sharp Kabushiki Kaisha

Inventor： FUJITA, Hideaki ,  KAMIYAMA, Haruki ,  KAMO, Tomonori ,  SUZUKI, Akihiro

IPC: G01N15/06 ,  G01N15/00 ,  G01N21/64

CPC classification number: G01N21/6486 ,  B03C3/41 ,  B03C3/47 ,  B03C2201/06 ,  B03C2201/24 ,  C12Q1/04 ,  F24F3/1603 ,  G01N15/0612 ,  G01N21/645 ,  G01N33/54313 ,  G01N2001/4038 ,  G01N2201/061 ,  G01N2201/0686

Abstract: There is provided a particle detector that detects biogenic particles with high sensitivity. The particle detector includes a collecting member 10 having a principal surface and configured to electrostatically collect particles on the principal surface, an irradiation unit 21 configured to irradiate the particles collected on the principal surface with excitation light, a light receiving unit 34 configured to receive fluorescence emitted from the particles by irradiation of the particles with the excitation light, and a detection unit configured to detect biogenic particles from the particles collected on the principal surface on the basis of a fluorescence intensity in the light receiving unit. The particle detector further includes a filter 37 disposed between the principal surface and the light receiving unit cut light with a wavelength emitted by irradiation of the excitation light from a substance that is generated on the principal surface when the particles are electrostatically collected.

Abstract translation: 提供了一种以高灵敏度检测生物颗粒的粒子检测器。 粒子检测器包括具有主表面并被构造为在主表面上静电收集颗粒的收集构件10，被配置为用激发光照射收集在主表面上的颗粒的照射单元21，被配置为接收荧光的光接收单元34 通过用激发光照射粒子而从粒子射出的检测单元，以及检测单元，其构成为根据受光单元中的荧光强度从主表面收集的粒子检测生物源粒子。 粒子检测器还包括设置在主表面和光接收单元之间的滤光器37，其在静电收集颗粒时，通过从主表面上产生的物质照射激发光而发出波长发射的光。

公开(公告)号：EP3165906A4

公开(公告)日：2018-01-17

申请号：EP15815411

申请日：2015-06-11

Applicant: MURATA MANUFACTURING CO

Inventor： YASUDA MASAAKI

IPC: G01N21/61 ,  G01N21/03 ,  G01N21/3504 ,  G01N33/00

CPC classification number: G01N21/3504 ,  G01N21/61 ,  G01N33/004 ,  G01N2201/0686

Abstract: A gas concentration measurement device (100) includes a waveguide member (90) including an entrance portion (91) and an exit portion (92); a rotating member; a first band pass filter (41) and a second band pass filter (42) that are provided on the rotating member and located on a pair of planes that intersect each other; and a rotational driving unit. The rotating member is rotated by the rotational driving unit so that the first band pass filter (41) and the second band pass filter (42) are selectively located at a transmitting position. When a portion of the rotating member, the first band pass filter (41), or the second band pass filter (42), the portion having a maximum radius of gyration around a rotating shaft, is defined as a maximum radius portion (38), and when a rotation locus obtained by imaginarily rotating the maximum radius portion (38) around the rotating shaft in a view along the rotating shaft is defined as a reference circle (C), the exit portion (92) is located in the reference circle (C).

公开(公告)号：EP3165904A4

公开(公告)日：2018-01-03

申请号：EP15814117

申请日：2015-06-11

Applicant: MURATA MANUFACTURING CO

Inventor： YASUDA MASAAKI ,  TSUBONO MASANORI ,  OGUSHI NAOKI

IPC: G01N21/61 ,  G01N21/3504 ,  G01N33/00

CPC classification number: G01N21/3504 ,  G01N21/61 ,  G01N33/004 ,  G01N2201/0686

Abstract: A gas concentration measurement device (100) measures a gas concentration based on an absorbance of sample gas in a region between a light source (20) that emits infrared light and a detector (60) that detects the infrared light. The gas concentration measurement device (100) includes a rotating member that is rotatable, a first band pass filter (41) and a second band pass filter (42) provided on the rotating member, and a rotational driving unit. The first band pass filter (41) and the second band pass filter (42) are located on a pair of planes that intersect each other. The rotational driving unit rotates the rotating member around the rotating shaft to switch between a first state, in which the infrared light from the light source (20) is transmitted through the first band pass filter (41), and a second state, in which the infrared light from the light source (20) is transmitted through the second band pass filter (42).

公开(公告)号：EP3166493A1

公开(公告)日：2017-05-17

申请号：EP15745255.8

申请日：2015-07-10

Applicant: Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO

Inventor： KLOMP, Dolf Jaap ,  WIERINGA, Fokko Pieter ,  STATHAM, Andrew

IPC: A61B5/1455 ,  G01N21/71 ,  G01N21/85

CPC classification number: G01N21/718 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/1605 ,  A61M1/3609 ,  A61M2205/3306 ,  G01N21/05 ,  G01N21/85 ,  G01N33/4875 ,  G01N2201/0686

Abstract: A spectroscopy device is disclosed for inline monitoring of analytes in bulk fluid streams, capable of maintaining sterile conditions. The device comprises a cassette suitable for holding a fluid analyte (151) and having a laser entry wall part and a detector wall part, the laser entry wall part arranged to be optically transparent to laser radiation of a predetermined wavelength and the detector wall part arranged to be optically transparent for spectral parts of interest. Laser transmission optics are provided to focus a laser beam to produce a breakdown plasma discharge within the fluid inside the cassette. A photodetector substrate is provided comprising an array of photosensors, tuned to detect characteristic emission lines from the plasma. The photodetector substrate is conformal to at least the detector wall part of the cassette. A placement provision is arranged for user removable placement of the cassette. Dichroic hot and cold mirrors are applied to selectively transmit/reflect excitation laser light and light emitted by the plasma.

Abstract translation: 公开了一种光谱学装置，用于在线监测散装流体流中的分析物，能够维持无菌条件。 该装置包括适于容纳流体分析物（151）并且具有激光入口壁部分和检测器壁部分的盒子，该激光入口壁部分被布置成对于预定波长的激光辐射是光学透明的并且检测器壁部分被布置 对感兴趣的光谱部分是光学透明的。 提供激光透射光学器件以聚焦激光束以在盒内的流体内产生击穿等离子体放电。 提供包括光电传感器阵列的光电检测器衬底，其经调谐以检测来自等离子体的特征发射线。 光电探测器衬底至少与盒的探测器壁部分共形。 放置设置被安排用于使用者可移除盒的放置。 应用二向色冷热镜以选择性地透射/反射由等离子​​体发射的激发激光和光。

公开(公告)号：WO2016007012A1

公开(公告)日：2016-01-14

申请号：PCT/NL2015/050509

申请日：2015-07-10

Applicant: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Inventor： KLOMP, Dolf Jaap ,  WIERINGA, Fokko Pieter ,  STATHAM, Andrew

IPC: A61B5/1455 ,  G01N21/71 ,  G01N21/85

CPC classification number: G01N21/718 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/1605 ,  A61M1/3609 ,  A61M2205/3306 ,  G01N21/05 ,  G01N21/85 ,  G01N33/4875 ,  G01N2201/0686

Abstract: A spectroscopy device is disclosed for inline monitoring of analytes in bulk fluid streams, capable of maintaining sterile conditions. The device comprises a cassette suitable for holding a fluid analyte (151) and having a laser entry wall part and a detector wall part, the laser entry wall part arranged to be optically transparent to laser radiation of a predetermined wavelength and the detector wall part arranged to be optically transparent for spectral parts of interest. Laser transmission optics are provided to focus a laser beam to produce a breakdown plasma discharge within the fluid inside the cassette. A photodetector substrate is provided comprising an array of photosensors, tuned to detect characteristic emission lines from the plasma. The photodetector substrate is conformal to at least the detector wall part of the cassette. A placement provision is arranged for user removable placement of the cassette. Dichroic hot and cold mirrors are applied to selectively transmit/reflect excitation laser light and light emitted by the plasma.

Abstract translation: 公开了一种用于在体液流中分析物的在线监测的光谱装置，其能够保持无菌条件。 所述装置包括适于保持流体分析物（151）并具有激光入口壁部分和检测器壁部分的盒，所述激光入口壁部分布置成对于预定波长的激光辐射是光学透明的，并且所述检测器壁部分布置 对于感兴趣的光谱部分来说是光学透明的。 提供激光传输光学器件以聚焦激光束以在盒内的流体内产生击穿等离子体放电。 提供了一种光电检测器基板，其包括被调谐以检测来自等离子体的特征发射线的光电传感器阵列。 光电检测器基板至少与盒的检测器壁部分共形。 布置放置用于盒的用户可移除放置。 应用二向色冷热反射镜以选择性地透射/反射激发激光和由等离子体发射的光。

公开(公告)号：WO2015091358A1

公开(公告)日：2015-06-25

申请号：PCT/EP2014/077755

申请日：2014-12-15

Applicant: UNIVERSITÄT WIEN ,  ÖSTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN

Inventor： ZEILINGER, Anton ,  RAMELOW, Sven ,  LAPKIEWICZ, Radek ,  BORISH, Victoria ,  BARRETO LEMOS, Gabriela

IPC: G02F1/39 ,  G06N99/00 ,  G01N21/64

CPC classification number: G01N21/35 ,  G01N21/4795 ,  G01N21/636 ,  G01N21/64 ,  G01N2201/06113 ,  G01N2201/0686 ,  G02F1/39

Abstract: A method comprising the steps of: generating one or more first, correlated photon pairs, each pair consisting of two photons with a wavelength λ 1 and a wavelength λ 2 , respectively, thereby generating a first and a second photon beam with wavelengths λ 1 and λ 2 , respectively, wherein preferably λ 1 ≠ λ 2 ; separating the photons of wavelength λ 1 and the photons of wavelength λ 2 ; illuminating an object with the photons having the wavelength generating one or more second, correlated photon pairs, each pair consisting of two correlated photons with a wavelength λ 1 and a wavelength λ 2' , respectively, thereby generating a third and a fourth photon beam with wavelength λ 1 ' and wavelength λ 2 ', respectively wherein λ 1 ' = λ 1 and λ 2 ' = λ 2 ; and overlapping photons of wavelength λι generated in the first step with photons of wavelength λ 1 generated in the fourth step, such that photons of wavelength λ 1 generated in either step are indistinguishable; overlapping photons of wavelength λ 2 generated in step with photons of wavelength λ 2 generated in the fourth step, such that photons of wavelength λ 2 generated in either step are indistinguishable; and using the overlapped photons of wavelength λ 2 for imaging and/or spectroscopy of the object; such that the photons that illuminate the object are not detected.

Abstract translation: 一种方法，包括以下步骤：产生一个或多个第一相关光子对，每对由分别由波长λ1和波长λ2的两个光子组成，从而分别产生具有波长λ1和λ2的第一和第二光子束 ，其中优选λ1≠λ2; 分离波长λ1的光子和波长λ2的光子; 用具有产生一个或多个第二相关光子对的波长的光子照射物体，每对分别由波长λ1和波长λ2'的两个相关光子组成，由此产生具有波长λ1的第三和第四光子束 '和波长λ2'，其中λ1'=λ1和λ2'=λ2; 并且在第一步骤中产生的波长λι的重叠光子与在第四步骤中产生的波长λ1的光子相比，使得在任一步骤中产生的波长λ1的光子是不可区分的; 在第四步骤中产生的波长为λ2的光子的步骤中产生的波长λ2的重叠光子，使得在任一步骤中产生的波长λ2的光子是不可区分的; 并使用波长λ2的重叠光子进行物体的成像和/或光谱分析; 使得照亮对象的光子未被检测到。

公开(公告)号：WO2014014956A1

公开(公告)日：2014-01-23

申请号：PCT/US2013/050753

申请日：2013-07-16

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： UTZINGER, Urs ,  BANERJEE, Bhaskar ,  RENKOSKI, Timothy, E. ,  RIAL, Nathaniel, S. ,  GRAVES, Logan

IPC: A61B1/05 ,  G01N21/64

CPC classification number: G01N21/6486 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  G01N21/4795 ,  G01N21/55 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6484 ,  G01N2201/0686

Abstract: Methods for reliable identification of low-contrast lesions within a tissue of a subject comprise delivering an excitation signal to the tissue, wherein the excitation signal is selected to stimulate tissue to produce autofluorescence and/or reflectance. The autofluorescence and/or reflectance is detected, and ratiometric images are produced based on the autofluorescence and/or reflectance images. An imaging system is provided which is configured to carry out such methods, irradiating tissue at a various possible excitation wavelengths, such as UV excitation wavelengths below 300 nm, to elicit fluorescence from specific native fluorophores.

Abstract translation: 用于可靠地鉴定受试者组织内的低对比度损伤的方法包括向组织递送激发信号，其中选择激发信号以刺激组织以产生自发荧光和/或反射。 检测自发荧光和/或反射率，并且基于自发荧光和/或反射图像产生比例图像。 提供了一种成像系统，其被配置为执行这样的方法，以各种可能的激发波长照射组织，例如低于300nm的UV激发波长，以引发特定天然荧光团的荧光。

公开(公告)号：WO2019073377A1

公开(公告)日：2019-04-18

申请号：PCT/IB2018/057808

申请日：2018-10-09

Applicant: CSIR

Inventor： COX, Ettienne

IPC: G01N21/3504 ,  G01M3/38 ,  G01N21/17

CPC classification number: G01N21/3504 ,  G01M3/38 ,  G01N2021/1765 ,  G01N2021/1772 ,  G01N2021/1795 ,  G01N2021/3513 ,  G01N2201/0221 ,  G01N2201/0231 ,  G01N2201/0612 ,  G01N2201/0616 ,  G01N2201/06186 ,  G01N2201/0686 ,  G01N2201/0696

Abstract: This invention relates to a method of and system for facilitating detection of a particular predetermined gas in a scene (14) under observation. The gas in the scene is typically associated with a gas leak in equipment. To this end, the system comprises an infrared camera arrangement (12); a strobing illuminator device (22) having a strobing frequency matched to a frame rate of the camera; and a processing arrangement (24). The processing arrangement is configured to store a prior frame obtained via the infrared camera arrangement; and compare a current frame with the stored prior frame and generate an output signal in response to said comparison. The system also comprises a display device (26) configured to display an output image based at least on the output signal generated by the processing arrangement so as to facilitate detection of the particular predetermined gas, in use.

公开(公告)号：WO2016002466A1

公开(公告)日：2016-01-07

申请号：PCT/JP2015/066872

申请日：2015-06-11

Applicant: 株式会社村田製作所

Inventor： 安田　雅章 ,  坪野　正則 ,  大串　直輝

IPC: G01N21/61 ,  G01N21/3504

CPC classification number: G01N21/3504 ,  G01N21/61 ,  G01N33/004 ,  G01N2201/0686

Abstract: 　ガス濃度測定装置（１００）は、赤外線を出射する光源（２０）と赤外線を検出する検出器（６０）との間の試料ガスの吸光度に応じてガス濃度を測定するものであって、回転可能に設けられた回転部材と、回転部材に設けられた第１バンドパスフィルタ（４１）および第２バンドパスフィルタ（４２）と、回転駆動部と、を備える。第１バンドパスフィルタ（４１）と第２バンドパスフィルタ（４２）とは、互いに交差する一対の面上に位置するように配置され、回転駆動部は、回転部材を回転軸まわりに回転させることにより、第１バンドパスフィルタ（４１）に光源（２０）からの赤外線を透過させる第１状態と、第２バンドパスフィルタ（４２）に光源（２０）からの赤外線を透過させる第２状態とを切り替える。

Abstract translation: 该气体浓度测定装置（100）根据发射红外线的光源（20）和检测红外线的检测器（60）之间的样品气体的吸光度来测量气体浓度，并且设置有旋转部件 能够旋转 提供给所述旋转部件的第一带通滤波器（41）和第二带通滤波器（42） 和旋转驱动单元。 第一带通滤光器（41）和第二带通滤光器（42）被布置成位于彼此相交的一对表面上。 旋转驱动单元使旋转构件绕旋转轴线旋转，从而在使来自光源（20）的红外线通过第一带通滤波器（41）的第一状态和第二状态之间切换，其中 使来自光源（20）的红外线通过第二带通滤光器（42）。