公开(公告)号：WO2009076427A1

公开(公告)日：2009-06-18

申请号：PCT/US2008/086206

申请日：2008-12-10

Applicant: STC.UNM ,  CHEN, Jingkuang

Inventor： CHEN, Jingkuang

IPC: A61B8/00

CPC classification number: A61B5/0095 ,  A61B5/0086 ,  A61B5/02007 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/483 ,  A61B2562/028 ,  Y10T29/49826

Abstract: A photoacoustic medical imaging device may include a substrate, an array of ultrasonic transducers on the substrate, at least one groove etched on the substrate, at least one optical fiber, and at least one facet. Each optical fiber is disposed in one of the grooves. Each facet is etched in one of the grooves and coated with a layer of metal having high infrared reflectivity. Each optical fiber is configured to guide infrared light from a light source through the fiber and toward the respective facet. The facet is configured to reflect the infrared light toward a target.

Abstract translation: 光声医学成像装置可以包括衬底，衬底上的超声换能器阵列，蚀刻在衬底上的至少一个凹槽，至少一个光纤和至少一个面。 每个光纤被布置在一个凹槽中。 每个刻面在一个凹槽中蚀刻并涂覆有具有高红外反射率的金属层。 每个光纤被配置为引导来自光源的红外光通过光纤并朝向相应的刻面。 小面被配置为将红外光反射到目标。

公开(公告)号：WO2009070331A2

公开(公告)日：2009-06-04

申请号：PCT/US2008/013209

申请日：2008-11-28

Applicant: STC.UNM ,  LARSON, Richard, S. ,  SKLAR, Larry, A. ,  EDWARDS, Bruce, S. ,  IVNITSKI-STEELE, Irena, D. ,  OPREA, Tudor, I. ,  LOVATO, Debbie, M. ,  KHAWAJA, Hadya, M. ,  WINTER, Stuart, S. ,  YOUNG, Susan, M.

Inventor： SKLAR, Larry, A. ,  EDWARDS, Bruce, S. ,  IVNITSKI-STEELE, Irena, D. ,  OPREA, Tudor, I. ,  LOVATO, Debbie, M. ,  KHAWAJA, Hadya, M. ,  WINTER, Stuart, S. ,  YOUNG, Susan, M.

IPC: A61K31/415 ,  A61K31/12 ,  A61P35/00

CPC classification number: A61K31/12 ,  A61K31/415 ,  A61K45/06 ,  A61K2300/00

Abstract: Compounds disclosed which inhibit ABCBl transporter protein are useful for treating diseases in which ABCBl transporter protein mediates the disease state, including numerous cancers, including hematopoietic cancers, including various leukemias, especially T-lineage acute lymphoblastic leukemia, as well as cancerous tumors, especially forms which exhibit multiple drug resistance. Pharmaceutical compositions which comprise an inhibitor of ABCBl transporter protein and at least one additional anticancer agent, optionally in combination with a pharmaceutically acceptable carrier, additive or excipient are another aspect of the present invention. A flow cytometry based, high-throughput screening (HST) assay that quantifies ABCBl efflux is also disclosed. Methods of identifying inhibitors of ABCBl, ABCG2 and ABCCl transporter proteins are also disclosed.

Abstract translation: 公开的抑制ABCB1转运蛋白的化合物可用于治疗其中ABCB1转运蛋白介导疾病状态的疾病，包括许多癌症，包括造血癌，包括各种白血病，特别是T-lineage急性成淋巴细胞性白血病，以及癌性肿瘤，特别是形式 其表现出多种耐药性。 包含ABCB1转运蛋白抑制剂和任选与药学上可接受的载体，添加剂或赋形剂组合的至少一种另外的抗癌剂的药物组合物是本发明的另一方面。 还公开了量化ABCB1流出的基于流式细胞术的高通量筛选（HST）测定。 还公开了鉴定ABCB1，ABCG2和ABCC1转运蛋白抑制剂的方法。

公开(公告)号：WO2008048704A2

公开(公告)日：2008-04-24

申请号：PCT/US2007/063673

申请日：2007-03-09

Applicant: STC.UNM ,  HERSEE, Stephen M. ,  WANG, Xin ,  SUN, Xinyu

Inventor： HERSEE, Stephen M. ,  WANG, Xin ,  SUN, Xinyu

IPC: H01L21/20 ,  H01L31/0304

CPC classification number: H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

Abstract: Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10- 1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

Abstract translation: 示例性实施例提供包括高质量（即，无缺陷）III-N族纳米线和均匀III-N纳米线阵列的半导体器件及其可制造的可扩展工艺，其中位置，取向，横截面特征，长度和 可以精确地控制每个纳米线的结晶度。 可以使用脉冲生长模式来制造公开的III-N纳米线和/或纳米线阵列，其提供约10nm至约1000微米的均匀长度，具有恒定的横截面特征，包括约10〜1000nm的示例性直径。 此外，可以通过聚结多个GaN纳米线和/或纳米线阵列来形成高质量的GaN衬底结构，以便制造可见的LED和激光器。 此外，核 - 壳纳米线/ MQW活性结构可以通过在每个纳米线的非极性侧壁上的核 - 壳生长形成。

公开(公告)号：WO2008008383A2

公开(公告)日：2008-01-17

申请号：PCT/US2007/015802

申请日：2007-07-11

Applicant: STC.UNM ,  TIMMINS, Graham, S.

Inventor： TIMMINS, Graham, S.

IPC: C12Q1/00

CPC classification number: A61K49/0008 ,  A61B5/0059 ,  A61B5/444 ,  A61B5/445 ,  G01R33/60

Abstract: The present invention is a system and methods of establishing a Melanocyte Protection Factor (MPF), which indicates the level of protection against DNA damage to a target cell, such as the level of protection a particular sunscreen offers against UVA rays when compared to the unprotected case, i.e., no sunscreen. The present invention determines and records levels of stable melanin radicals (SMR) in a target cell. Light is applied to the target cell forming light-induced melanin radicals (LIR). The levels of SMR and intensity of LIR are measured to determine the amount of incident light reaching the target cell. Since LIR is proportional to the square root of light intensity reaching the target cell, the ratio of light reaching the target cell is defined as the MPF (I).

Abstract translation: 本发明是建立黑素细胞保护因子（MPF）的系统和方法，其指示针对靶细胞的DNA损伤的保护水平，例如特定防晒剂与未受保护的相比对UVA射线提供的保护水平 情况，即没有防晒霜。 本发明确定并记录靶细胞中稳定的黑色素自由基（SMR）的水平。 光被施加到形成光诱导的黑色素自由基（LIR）的靶细胞上。 测量LIR的SMR和强度的水平以确定到达靶细胞的入射光的量。 由于LIR与到达目标单元的光强度的平方根成正比，所以到达目标单元的光的比率被定义为MPF（I）。

公开(公告)号：US11594796B2

公开(公告)日：2023-02-28

申请号：US16700745

申请日：2019-12-02

Applicant: STC.UNM

Inventor： Firas Nazem Ayoub ,  Christos G. Christodoulou ,  Emil Ardelean ,  Steven Lane

IPC: H01Q13/10 ,  H01P1/17 ,  H01Q5/35

Abstract: A polarizer including an antenna connected to a waveguide. The waveguide including a broad wall having a cross-slot in communication with at least one port.

公开(公告)号：US11349279B2

公开(公告)日：2022-05-31

申请号：US16775200

申请日：2020-01-28

Applicant: STC.UNM

Inventor： Marek Osinski ,  Alexander Neumann ,  Gennady A. Smolyakov

IPC: H01S5/024 ,  H01S5/34 ,  H01S5/026 ,  H01S5/347 ,  H01S3/04

Abstract: A semiconductor device comprising a waveguide having a core, said core having inserted therein one or more layers of nanoemitters.

公开(公告)号：US11221388B1

公开(公告)日：2022-01-11

申请号：US16442358

申请日：2019-06-14

Applicant: STC.UNM

Inventor： Stefan Posse

IPC: G01R33/565 ,  A61B5/055 ,  A61B5/00 ,  G01R33/48

Abstract: A method for the compensation of magnetic field inhomogeneity in magnetic resonance spectroscopic imaging comprising the steps of using dynamic k-space expansion in combination with parallel imaging.

公开(公告)号：US11076153B2

公开(公告)日：2021-07-27

申请号：US15747982

申请日：2016-07-31

Applicant: STC.UNM

Inventor： Marios Stephanou Pattichis ,  Yuebing Jiang ,  Cong Zong ,  Gangadharan Esakki ,  Venkatesh Jatla ,  Andreas Panayides

IPC: H04N19/127 ,  H04N19/172 ,  H04N19/149 ,  H04N19/119 ,  H04N19/126 ,  H04N19/147

Abstract: System and methods for the joint control of reconstructed video quality, computational complexity and compression rate for intra-mode and inter-mode video encoding in HEVC. The invention provides effective methods for (i) generating a Pareto front for intra-coding by varying CTU parameters and the QP, (ii) generating a Pareto front for inter-coding by varying GOP configurations and the QP, (iii) real-time and offline Pareto model front estimation using regression methods, (iv) determining the optimal encoding configurations based on the Pareto model by root finding and local search, and (v) robust adaptation of the constraints and model updates at both the CTU and GOP levels.

公开(公告)号：US20210183473A1

公开(公告)日：2021-06-17

申请号：US16761663

申请日：2018-11-08

Applicant: STC.UNM.

Inventor： Trilce PROCYON ESTRADA-PIEDRA ,  Jeremy BENSON ,  Hector CARRILLO-CABADA ,  Ewa DEELMAN ,  Michela TAUFER

IPC: G16B45/00 ,  G16B15/30 ,  G16B15/20 ,  G16B40/00

Abstract: The present invention is directed to a system and methods of predicting protein function through a process of encoding protein structural information into a computer readable format and the use of a convolutional neural network designed to recognize such encoded format.

公开(公告)号：US10907219B2

公开(公告)日：2021-02-02

申请号：US15119506

申请日：2015-02-18

Applicant: STC.UNM ,  Fu-Sen Liang ,  Wei Wang

Inventor： Fu-Sen Liang ,  Wei Wang

IPC: C12Q1/68 ,  C12Q1/6897

Abstract: This disclosure describes compositions and methods that involve a first modular component and a second modular component. The first modular component includes a first target molecule coupled to a first dimerizing moiety. The second modular component includes a second target molecule coupled to a second dimerizing moiety. The first dimerizing moiety dimerizes with the second dimerizing moiety when the first dimerizing moiety binds a chemical induced proximity (CIP) inducer.