公开(公告)号：EG21717A

公开(公告)日：2002-02-27

申请号：EG118098

申请日：1998-09-29

Applicant: NEUROGEN CORP

Inventor： ALBAUGH PAMELA

IPC: A61K31/4375 ,  A61K31/496 ,  A61P21/02 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  C07D221/00 ,  C07D471/04 ,  C07D4 ,  A61K31/44 ,  C07D201/00

公开(公告)号：AU3473601A

公开(公告)日：2001-08-14

申请号：AU3473601

申请日：2001-02-01

Applicant: ALLERGAN PHARMACEUTICALS INT LTD

Inventor： CAZER FREDRICK DANA ,  PERRY GREGORY EUGENE ,  BILLINGS DENNIS MICHAEL ,  REDMAN-FUREY NANCY LEE

IPC: A61K31/663 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58

Abstract: The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.

公开(公告)号：AU2925799A

公开(公告)日：1999-08-23

申请号：AU2925799

申请日：1999-02-05

Applicant: DUPHAR INT RES

Inventor： HARTOG JACOBUS A J DEN ,  VISSER GERBEN M ,  STEEN BARTHOLOMEUS J VAN ,  TULP MARTINUS T M ,  RONKEN ERIC ,  KRUSE CORNELIS G

IPC: A61K31/4709 ,  A61K31/496 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D201/00 ,  C07D215/38 ,  C07D401/12 ,  C07D405/12

Abstract: The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R1)n represents 1 or 2 substituents, which can be the same or different, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, or two groups R1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R2)p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R2)p is a methylene bridge or ethylene bridge, R3 is hydrogen or methyl, and (R)m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, on the understanding that R1 cannot represent o-OCH3 when X is nitrogen, (R2)p and R3 are hydrogen, m is 0 and n is 1

公开(公告)号：TR9800403A3

公开(公告)日：1998-09-21

申请号：TR9800403

申请日：1998-03-06

Applicant: F.HOFFMANN-LA ROCHE AG

Inventor： STEFAN ABRECHT

IPC: C07D463/00 ,  B01J27/08 ,  C07B61/00 ,  C07D207/26 ,  C07D207/273 ,  C07D498/04 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/56 ,  C07D505/00 ,  C07D507/08 ,  C07D201/00

CPC classification number: C07D207/273 ,  C07D501/00 ,  C07D505/00

公开(公告)号：IN181237B

公开(公告)日：1998-05-02

申请号：IN389MA1993

申请日：1993-06-08

Applicant: DSM NV

Inventor： THOMISSEN PETRUS JOZEF HUBERTU ,  BOSMAN HUBERTUS JOHANNES MECHT

IPC: C07D201/00

公开(公告)号：ID17781A

公开(公告)日：1998-01-29

申请号：ID971025

申请日：1997-03-27

Applicant: PFIZER

Inventor： HOWARD HARRY R

IPC: C07D215/22 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/47 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/55 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P9/12 ,  A61P25/00 ,  A61P43/00 ,  C07D205/08 ,  C07D207/26 ,  C07D207/36 ,  C07D207/38 ,  C07D209/34 ,  C07D211/76 ,  C07D211/86 ,  C07D217/24 ,  C07D223/10 ,  C07D401/10 ,  C07D403/00 ,  C07D403/10 ,  C07D201/00

Abstract: The present invention relates to lactam derivatives of the formula wherein R 1 , R 2 , R 3 , A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to processes and intermediates for their preparation, and to their medicinal use as selective agonists and antagonists of serotonin 1 (5-HT 1 ) receptors, specifically, of one or both of the 5-HT 1A and 5-HT 1D receptors. These compounds are useful in treating or preventing migraine, depression and other disorders for which a 5-HT 1 agonist or antagonist is indicated.

公开(公告)号：CA2246459A1

公开(公告)日：1997-08-21

申请号：CA2246459

申请日：1997-02-05

Applicant: DU PONT ,  DSM NV

Inventor： GUIT RUDOLF PHILIPPUS MARIA ,  FRENTZEN YVONNE HELENE

IPC: C07D201/00 ,  C07D201/08 ,  C07D201/16 ,  C07D223/10

Abstract: Process to separate .epsilon.-caprolactam from an aqueous mixture containing .epsilon.-caprolactam and at least 0.5 wt.% oligomers, wherein the separation is performed by extraction using an organic extraction agent. The aqueous mixture may be obtained in a process to prepare .epsilon.-caprolactam starting from 6-aminocapronitrile or in a process to prepare .epsilon.-caprolactam starting from 6-aminocaproic acid.

公开(公告)号：DE4422237A1

公开(公告)日：1996-01-04

申请号：DE4422237

申请日：1994-06-24

Applicant: GRUENENTHAL GMBH

Inventor： BOEHLKE HORST DIPL CHEM DR ,  FINKAM MICHAEL DIPL CHEM DR ,  SCHNEIDER JOHANNES DR ,  ZIMMER OSWALD DIPL CHEM DR ,  ZWINGENBERGER KAI DR

IPC: A61K31/40 ,  A61K31/425 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61P9/00 ,  A61P37/06 ,  C07D401/04 ,  C07D417/04 ,  C07D421/04 ,  C07D201/00

Abstract: Use of lactams of formula (I) in racemic or optically active form as pharmaceutical agents is new: X = CH2, S or Se; R = 1-6C alkyl or benzyl; Z, Z' = CH2 or CO, but not both CH2. Also claimed are cpds. (Ia) which are the same as (I), except that X is not S when Z = CO , and Z' = CH2.

公开(公告)号：NL8702458A

公开(公告)日：1988-05-02

申请号：NL8702458

申请日：1987-10-14

Applicant: ERBA FARMITALIA

IPC: A61K31/397 ,  A61P31/04 ,  C07D205/08 ,  C07D201/00

Abstract: Process for preparing compounds according to formula (I) (I) wherein R1 and R2 represent a hydrogen atom or a protective group and R3 represents a C1-C10 alkyl or an aryl group, by oxidation of compounds according to formula (II) (II) wherein R1, R2 and R3 have the above-mentioned meanings, in a two-phase system comprising: a) an organic phase including a 4-acylazetidinone compound (II) and an "onium" salt dissolved in a medium immiscible with water, b) an aqueous solution including an alkali or alkaline-earth metal salt of an organic or inorganic peracid. 4-Acyloxyazetidinones (I) are useful intermediates in the synthesis of anti-bacterial compounds.

公开(公告)号：PT82741A

公开(公告)日：1986-07-01

申请号：PT8274186

申请日：1986-06-09

Applicant: BEECHAM GROUP PLC

IPC: C07D333/24 ,  C07D463/00 ,  C07D499/00 ,  C07D499/64 ,  C07D499/80 ,  C07D501/20 ,  C07D501/58 ,  C07D505/00 ,  C07D201/00