公开(公告)号：US20070102639A1

公开(公告)日：2007-05-10

申请号：US10580671

申请日：2004-12-01

Applicant: Christopher Cutler ,  Alexander Vass

Inventor： Christopher Cutler ,  Alexander Vass

IPC: G01J5/02

CPC classification number: G01N21/3504 ,  G01N21/314 ,  G01N21/71 ,  G01N2021/0385 ,  G01N2201/0236 ,  G01N2201/024 ,  G01N2201/0632

Abstract: A gas sensor comprises a cavity for containing a gas, means for generating radiation which is transmitted through the cavity and includes one or more wavelengths which is absorbed in use by a gas to be detected; and a detector for detecting radiation which has passed through the cavity. The walls of the cavity are sufficiently reflective to the radiation that the cavity is substantially uniformally illuminated with the radiation.

Abstract translation: 气体传感器包括用于容纳气体的空腔，用于产生辐射的装置，其透射通过空腔并且包括一个或多个被待检测气体吸收的波长; 以及用于检测已经通过空腔的辐射的检测器。 空腔的壁足够地反射辐射，空腔基本上被辐射均匀地照射。

公开(公告)号：US07154603B2

公开(公告)日：2006-12-26

申请号：US11493446

申请日：2006-07-26

Applicant: Rodney H. Banks

Inventor： Rodney H. Banks

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N33/18 ,  G01N2021/157 ,  G01N2021/6482 ,  G01N2201/0221 ,  G01N2201/024 ,  G01N2201/062 ,  G01N2201/064

Abstract: Described and claimed is an interchangeable tip-open cell fluorometer comprising a housing and a fluorometric probe tip interchangeably connected to the housing, the probe tip including a probe tip housing defining an open cell and enclosing a probe optical arrangement, the probe optical arrangement including an excitation source and a fluorescence detector wherein the excitation source is aimed directly into the fluorescence detector such that a sample can be fluorometrically detected. Also claimed is a method of using this interchangeable tip-open cell fluorometer for detecting fluorescent signals emitted by one or more fluorophores from samples from a natural or industrial water system. The fluorometer, when coupled with a controller, is capable of monitoring and optionally controlling an industrial process or system.

公开(公告)号：US20060262309A1

公开(公告)日：2006-11-23

申请号：US11493446

申请日：2006-07-26

Applicant: Rodney Banks

Inventor： Rodney Banks

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N33/18 ,  G01N2021/157 ,  G01N2021/6482 ,  G01N2201/0221 ,  G01N2201/024 ,  G01N2201/062 ,  G01N2201/064

Abstract: Described and claimed is an interchangeable tip-open cell fluorometer comprising a housing and a fluorometric probe tip interchangeably connected to the housing, the probe tip including a probe tip housing defining an open cell and enclosing a probe optical arrangement, the probe optical arrangement including an excitation source and a fluorescence detector wherein the excitation source is aimed directly into the fluorescence detector such that a sample can be fluorometrically detected. Also claimed is a method of using this interchangeable tip-open cell fluorometer for detecting fluorescent signals emitted by one or more fluorophores from samples from a natural or industrial water system. The fluorometer, when coupled with a controller, is capable of monitoring and optionally controlling an industrial process or system.

Abstract translation: 描述和要求保护的是可互换的尖端开孔单元荧光计，其包括壳体和可互换地连接到壳体的荧光探针尖端，探针尖端包括限定开放单元并包围探针光学布置的探针尖端壳体，探针光学布置包括 激发源和荧光检测器，其中激发源直接瞄准荧光检测器，使得样品可被荧光测量。 还要求保护的是使用这种可互换的尖端开放式荧光计来从天然或工业水系统的样品中检测由一种或多种荧光团发射的荧光信号的方法。 当与控制器耦合时，荧光计能够监测和可选地控制工业过程或系统。

公开(公告)号：US20030048445A1

公开(公告)日：2003-03-13

申请号：US10241451

申请日：2002-09-12

Inventor： Eugene Tokhtuev ,  Anatoly Skirda ,  Viktor Slobodyan ,  Christopher Owen

IPC: G01N021/27 ,  G01N021/64 ,  G01N021/85

CPC classification number: G01N21/8507 ,  G01N21/15 ,  G01N21/274 ,  G01N21/276 ,  G01N21/645 ,  G01N33/1886 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2021/6478 ,  G01N2201/0218 ,  G01N2201/024 ,  G01N2201/0627 ,  G01N2201/0693 ,  Y10T436/11

Abstract: A multichannel fluorosensor includes an optical module and an electronic module combined in a watertight housing with an underwater connector. The fluorosensor has an integral calibrator for periodical sensitivity validation of the fluorosensor. The optical module has one or several excitation channels and one or several emission channels that use a mutual focusing system. To increase efficiency, the excitation and emission channels each have a micro-collimator made with one or more ball lenses. Each excitation channel has a light emitting diode and an optical filter. Each emission channel has a photodiode with a preamplifier and an optical filter. The electronic module connects directly to the optical module and includes a lock-in amplifier, a power supply and a controller with an A/D converter and a connector. The calibrator provides a response proportional to the excitation intensity, and matches with spectral parameter of fluorescence for the analyzed fluorescent substance.

Abstract translation: 多通道氟传感器包括光学模块和组合在具有水下连接器的防水壳体中的电子模块。 氟传感器具有用于氟传感器周期灵敏度验证的积分校准器。 光学模块具有一个或多个激发通道和使用相互聚焦系统的一个或多个发射通道。 为了提高效率，激发和发射通道各自具有由一个或多个球透镜制成的微型准直器。 每个激励通道都有一个发光二极管和一个滤光器。 每个发射通道具有带有前置放大器和光学滤波器的光电二极管。 电子模块直接连接到光模块，包括锁定放大器，电源和带有A / D转换器和连接器的控制器。 校准器提供与激发强度成比例的响应，并与分析的荧光物质的荧光光谱参数相匹配。

公开(公告)号：US06192168B1

公开(公告)日：2001-02-20

申请号：US09288957

申请日：1999-04-09

Applicant: Mark J. Feldstein ,  Joel P. Golden ,  Frances S. Ligler ,  Chris A. Rowe

Inventor： Mark J. Feldstein ,  Joel P. Golden ,  Frances S. Ligler ,  Chris A. Rowe

IPC: G02B600

CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/7703 ,  G01N33/54373 ,  G01N33/54393 ,  G01N2021/7709 ,  G01N2021/7776 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/024 ,  G02B6/10 ,  G02B6/4206

Abstract: A multimode waveguide device for assays includes a multimode waveguide with a patterned, reflective surface coating. The exposed portion or portions of the reflectively coated waveguide surface are for analyte recognition. A fluidics cell is attached to the waveguide so that the channel or channels of the fluidics cell match with the exposed portion or portions of the waveguide surface. The channel or channels direct one or more sample fluids over the exposed portion or portions of the waveguide surface. The reflective coating minimizes loss and scattering of excitation and fluorescence light during a fluorescence assay.

Abstract translation: 用于测定的多模波导器件包括具有图案化的反射表面涂层的多模波导。 反射涂覆的波导表面的暴露部分或部分用于分析物识别。 流体池连接到波导，使得流体池的通道或通道与波导表面的暴露的部分或部分匹配。 通道或通道将一个或多个样品流体引导到波导表面的暴露部分或部分上。 反射涂层在荧光测定期间使激发和荧光的损耗和散射最小化。

公开(公告)号：US5807750A

公开(公告)日：1998-09-15

申请号：US434527

申请日：1995-05-02

Applicant: Marc M. Baum ,  Harry C. Lord

Inventor： Marc M. Baum ,  Harry C. Lord

IPC: G01N21/31 ,  G01N21/33 ,  G01N21/00 ,  G01N21/01 ,  G01N21/35

CPC classification number: G01N21/31 ,  G01N21/33 ,  G01N2201/024

Abstract: A liquid and gas analyzing system that provides a sample collecting probe that delivers the sample through inert materials to prevent any contamination. For gas analyzing for environmental monitoring process control, a sample collecting probe having a borosilicate glass tube liner connected through an inner spiral tube to the analyzer prevents contamination. The system then delivers the sample to a single pass radiated optical cell by a light beam. The light beam is collected by a miniature CCD array spectrometer and delivered to an industrial PC. The output from the industrial PC is then delivered to a software controlled data acquisition system for analysis. The system is constructed to be a modular in design allowing addition of complementary components for measuring and analyzing different materials. The system described can be used for extractive gas analysis as well as extractive liquid analysis for monitoring stack gases, environmental air or general environmental monitoring and with modifications for breath analysis and human saliva and blood testing. The system is also adaptable for long path remote sense gas monitoring of fence lines and for leak detection.

Abstract translation: 液体和气体分析系统，提供样品收集探针，通过惰性材料传送样品以防止任何污染。 对于用于环境监测过程控制的气体分析，具有通过内螺旋管连接到分析器的硼硅酸盐玻璃管衬套的样品采集探针防止污染。 然后，系统通过光束将样品传送到单次辐射光学单元。 光束由微型CCD阵列光谱仪收集并传送到工业PC。 然后将工业PC的输出传送到软件控制的数据采集系统进行分析。 该系统被设计为模块化设计，允许添加用于测量和分析不同材料的互补部件。 所描述的系统可用于萃取气体分析以及用于监测烟气，环境空气或一般环境监测的萃取液分析，以及用于呼吸分析和人体唾液和血液测试的修改。 该系统还适用于围栏线路的远程远程遥控气体监测和泄漏检测。

公开(公告)号：US5202744A

公开(公告)日：1993-04-13

申请号：US669407

申请日：1991-03-22

Applicant: Thomas A. Louis

Inventor： Thomas A. Louis

IPC: G01J1/44 ,  G01N21/21 ,  G01N21/64 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01N21/6408 ,  G01N21/6445 ,  G01N21/6489 ,  G02B21/00 ,  G01J2001/442 ,  G01J2001/4466 ,  G01N21/21 ,  G01N2201/024

Abstract: The present invention relates to an optical routing module (2) suitable for use in a light microscope (1) for sample inspection simultaneously with a primary light source (10) and a secondary light source (7) of different wavelength. The module (2) comprises a housing mounting first and second polarizing beam splitters PBS1, PBS2 along a primary light beam pathway through the module and having secondary light beam inlet and outlet means (5,6) opposite different ones of the polarizing beam splitters PBS1, PBS2, which have a narrow predetermined operating wavelength range, defined between s- and p-plane transitional wavelengths, which substantially excludes the primary light source wave length band and such that at least one polarizing plane component of each of the secondary light source and a secondary light output from the sample is subjected to a different one of transmission and reflection from that to which the primary light source is subjected at each of the first and second polarizing beam splitters PBS1, PBS2, which are further formed and arranged for defining a secondary light beam pathway from the inlet (5) to the outlet (6) so that the secondary light beam pathway is brought substantially into alignment with an outward leg of said primary beam pathway upstream of the sample by said first polarizing beam splitter PBS1 and is separated back out from a return leg of said primary light beam pathway downstream of the sample by said second polarizing beam splitter PBS2 whereby in use of the module (2) in a light microscope (1), the area of incidence of the secondary light beam with the sample may be monitored via the primary light beam.

Abstract translation: PCT No.PCT / GB89 / 00845 Sec。 371日期1991年3月22日 102（e）1991年3月22日PCT PCT。 出版物WO90 / 01692 日期：1990年02月22日。本发明涉及一种适用于光学显微镜（1）中的光路由模块（2），用于与主光源（10）和二次光源（7）同时进行样品检查 不同波长。 模块（2）包括沿着主光束路径穿过模块安装第一和第二偏振分束器PBS1，PBS2的壳体，并且具有与不同偏振分束器PBS1相对的次级光束入口和出口装置（5,6） ，具有狭窄的预定工作波长范围的PBS2，其定义在s面和p面过渡波长之间，其基本上不包括初级光源波长带，并且使得每个次光源的至少一个偏振平面分量和 从样品的二次光输出经受与第一和第二偏振分束器PBS1，PBS2中的每一个处经受一次光源的透射和反射不同的透射和反射，所述第一和第二偏振分束器PBS1，PBS2进一步形成并布置用于限定 从入口（5）到出口（6）的次级光束路径，使得次级光束路径基本上对准w 以所述第一偏振光束分离器PBS1在样品上游的所述主光束通路的向外的腿部，并且通过所述第二偏振分束器PBS2从样品下游的所述主光束通路的返回支路分离出来，由此使用 在光学显微镜（1）中的模块（2）中，可以通过主光束监测与样本的次级光束的入射面积。

公开(公告)号：US5116759A

公开(公告)日：1992-05-26

申请号：US544681

申请日：1990-06-27

Applicant: Stanley M. Klainer ,  Johnny R. Thomas ,  Marcus S. Butler

Inventor： Stanley M. Klainer ,  Johnny R. Thomas ,  Marcus S. Butler

IPC: G01N21/01 ,  G01N21/03 ,  G01N21/25 ,  G01N21/75 ,  G01N21/77 ,  G01N21/80

CPC classification number: G01N21/253 ,  G01N21/75 ,  G01N2021/0193 ,  G01N2021/0325 ,  G01N2021/0385 ,  G01N2021/1738 ,  G01N21/77 ,  G01N21/80 ,  G01N2201/024 ,  G01N2201/0415 ,  Y10S436/811 ,  Y10T436/17 ,  Y10T436/172307 ,  Y10T436/18 ,  Y10T436/19 ,  Y10T436/206664 ,  Y10T436/212

Abstract: Single or multi-cell reservoir sensors with single illumination sources and one or more detectors per cell unit have an arrangement whereby a gaseous, vapor or liquid sample enters the cell body and interacts with a sensing solution to detect and quantify a given species. Entrance of the sample into the sensor is through an opening in the cell body which may be covered with a membrane to contain the sensing reagent and to presort the species entering the cell. Reservoir cells can be used with organic, inorganic or biochemical sensing materials. A variety of sensors as alcohol, drugs of abuse, organic halides, cyanide and inorganic ions are provided.

Abstract translation: 具有单个照明源和每个单元单元的一个或多个检测器的单池或多池容器传感器具有这样的布置，其中气体，蒸气或液体样品进入细胞体并与感测溶液相互作用以检测和定量给定物种。 样品进入传感器的入口通过细胞体中的开口，其可以用膜覆盖以容纳感测试剂并且预先分解进入细胞的物质。 储层细胞可用于有机，无机或生化传感材料。 提供各种传感器作为酒精，滥用药物，有机卤化物，氰化物和无机离子。

公开(公告)号：US5044755A

公开(公告)日：1991-09-03

申请号：US318245

申请日：1989-03-03

Applicant: Isaac Landa ,  Michael M. Anthony ,  George E. Toth

Inventor： Isaac Landa ,  Michael M. Anthony ,  George E. Toth

IPC: G01N21/85

CPC classification number: G01N21/8507 ,  G01N2201/024 ,  G01N2201/0638

Abstract: A modular probe is provided to enable introduction of light to a sample to be analyzed by an electro-optical device. The probe of the present invention may include an optical rod or other device for propagating light, an optical barrel which in part surrounds the optical rod, and a sleeve which is provided to attach the probe to a source of light such as a fiber optical bundle. The probe may be fitted with a bidirectional focusing adapter and a reflective tip. A transverse probe is also described.

Abstract translation: 提供了一种模块化探针，以便能够将光引入待通过电光装置分析的样品。 本发明的探针可以包括用于传播光的光学棒或其他装置，部分围绕光学棒的光学镜筒和设置成将探针连接到光源的套筒，例如光纤束 。 探头可以配有双向聚焦适配器和反射尖端。 还描述了横向探针。

公开(公告)号：US5039219A

公开(公告)日：1991-08-13

申请号：US357118

申请日：1989-05-26

Applicant: Douglas R. James ,  William R. Ware

Inventor： Douglas R. James ,  William R. Ware

IPC: G01J3/44 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2201/024

Abstract: Disclosed is an integrated, multi-module luminescence measuring system. The system can selectively conduct lifetime decay or steady-state measurements of light emitted by a sample which receives exitation light. The system includes: a sample chamber which directs monochromatized, focused excitation light from a selected source at a selected sample and directs any resultant emitted light through a monochromator to either a first gated photodetector or a second regular photodetector. Also present is a reference module with a regular photodetector which may selectively receive a portion of the excitation light. A lifetime decay detector module pulses a selected light source and the gated photodetector so that a converter produces digital signals related to output signals from the photodetector, the digital signals representing the integral of the intensity of the emitted light over a selected time. A steady-state detector module pulses a selected light source and includes a resettable integrator-A/D converter combination which receives the output from the regular photodetectors and produces digital signals representing the integrals over varying time intervals of such outputs. The integrator is reset and the A/D convertor is turned on whenever the light source is pulsed. A data processing module controls sample selection, the wavelengths of the excitation and emitted lights, light source selection, the number and time-width of the various integrations, and the storage and processing of the resulting digital signals.

Abstract translation: 公开了一种集成的多模块发光测量系统。 该系统可以选择性地进行寿命衰减或稳态测量由接收激发光的样品发射的光。 该系统包括：样品室，其在所选择的样品处引导来自所选源的单色化聚焦的激发光，并将任何合成的发射光通过单色仪引导到第一门控光电检测器或第二规则光电检测器。 还存在具有常规光电检测器的参考模块，其可以选择性地接收一部分激发光。 寿命衰减检测器模块脉冲选择的光源和门控光电检测器，使得转换器产生与来自光电检测器的输出信号相关的数字信号，数字信号表示在所选择的时间内发射的光的强度的积分。 稳态检测器模块脉冲选择的光源并且包括可复位积分器A / D转换器组合，其接收来自常规光电检测器的输出并且产生表示在这些输出的变化时间间隔上的积分的数字信号。 积分器复位，只要光源被脉冲，A / D转换器就会打开。 数据处理模块控制样品选择，激发和发射光的波长，光源选择，各种积分的数量和时间宽度，以及所得数字信号的存储和处理。