公开(公告)号：JP2002193926A

公开(公告)日：2002-07-10

申请号：JP2000389408

申请日：2000-12-21

Applicant: NAT INST OF ADV IND & TECHNOL

Inventor： HATADA KIYOTAKA ,  SATO OSAMU ,  KANAKUBO MITSUHISA ,  IKUSHIMA YUTAKA ,  TORII KAZUO

IPC: C07D205/08 ,  C07D201/08

Abstract: PROBLEM TO BE SOLVED: To provide the synthetic method of a β-lactam in the presence of high-temperature and high-pressure water, and a manufacturing method of the β lactam. SOLUTION: This synthetic method of the β-lactam is characterized in that the β-lactam is synthesized by reacting a β-amino acid in the presence of high- temperature and high-pressure water. In this case, characteristically, β-lactam is rapidly synthesized by cyclizing the β-amino acid under the condition that the water temperature is 200 deg.C or higher and the water pressure is 10 MPa or higher. The manufacturing method of the β-lactam is characterized in that the β-lactam is synthesized by reacting the β-amino acid in the presence of the high-temperature and high-pressure water and then separated and purified with a separating agent for column separation.

公开(公告)号：JP2002518477A

公开(公告)日：2002-06-25

申请号：JP2000555868

申请日：1999-06-24

IPC: C07D223/12 ,  C07C255/24 ,  C07D201/08 ,  C07D223/10

公开(公告)号：JP2002121183A

公开(公告)日：2002-04-23

申请号：JP2000314730

申请日：2000-10-16

Applicant: KAGAWA INDUSTRY SUPPORT FOUND

Inventor： UOSAKI YASUHIRO ,  MORIYOSHI TAKASHI ,  TSUKURIDA HIROSHI ,  HATA KAZUAKI ,  ASAHI SHINKICHI

IPC: C07D223/10 ,  C07D201/08 ,  C07D207/263 ,  C07D211/76

Abstract: PROBLEM TO BE SOLVED: To improve a method for closing a ring of an amino acid for producing a ring closure compound used for an intermediate for producing a medicine or a reagent intermediate from the amino acid, improving the yield and purity of the product, reducing its reacting time, not requiring a catalyst and not generating byproducts. SOLUTION: This method for closing the ring of the amino acid is provided by bringing high temperature and high pressure water at 100-400 deg.C temperature and 5-100 MPa pressure in contact with the amino acid for dehydrating the amino acid to perform the ring closure of the amino acid.

公开(公告)号：JP2001524541A

公开(公告)日：2001-12-04

申请号：JP2000523192

申请日：1998-11-30

IPC: B01J23/00 ,  B01J27/18 ,  B01J27/187 ,  C07D201/08

公开(公告)号：JP2001521526A

公开(公告)日：2001-11-06

申请号：JP54415098

申请日：1998-04-14

IPC: B01J31/24 ,  C07B61/00 ,  C07D201/02 ,  C07D201/08 ,  C07D223/10 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36

公开(公告)号：JP2001514076A

公开(公告)日：2001-09-11

申请号：JP2000508655

申请日：1998-08-24

IPC: B01J21/06 ,  B01J37/06 ,  C07D201/08

公开(公告)号：JP2001500123A

公开(公告)日：2001-01-09

申请号：JP51250998

申请日：1997-08-28

IPC: C07D201/00 ,  C07D201/08

公开(公告)号：JP2000512615A

公开(公告)日：2000-09-26

申请号：JP52921397

申请日：1997-02-05

IPC: C07D201/00 ,  C07D201/08 ,  C07D201/16 ,  C07D223/10

公开(公告)号：JP2000511919A

公开(公告)日：2000-09-12

申请号：JP50122298

申请日：1997-06-13

IPC: C07D201/08 ,  C07D201/16 ,  C07D223/10

Abstract: PCT No. PCT/EP98/03098 Sec. 371 Date Dec. 9, 1998 Sec. 102(e) Date Dec. 9, 1998 PCT Filed Jun. 13, 1997 PCT Pub. No. WO97/47596 PCT Pub. Date Dec. 18, 1997Crude caprolactam is purified by reaction with a complex hydride of boron or of aluminum.

公开(公告)号：JP2000504743A

公开(公告)日：2000-04-18

申请号：JP53002097

申请日：1997-02-12

IPC: C07D201/08