公开(公告)号：US10153725B2

公开(公告)日：2018-12-11

申请号：US15114374

申请日：2015-01-30

Applicant: STC.UNM

Inventor： Ganesh Balakrishnan ,  Christopher Hains ,  Andrew Aragon

IPC: H02J7/00 ,  H02S40/22 ,  G02B6/42 ,  H01L31/054 ,  H02S40/32 ,  H02S40/38 ,  H02J7/35 ,  F21V8/00

Abstract: A device includes a body and a rechargeable battery positioned within the body. A solar cell is coupled to the body and in communication with the battery. A connector is coupled to the body and configured to engage a corresponding connector of a fiber optic cable.

公开(公告)号：US20180349100A1

公开(公告)日：2018-12-06

申请号：US16051427

申请日：2018-07-31

Applicant: STC.UNM

Inventor： James Plusquellic

IPC: G06F7/58 ,  H04L9/08 ,  G09C1/00 ,  H04L9/00

CPC classification number: G06F7/588 ,  G06F2207/58 ,  G09C1/00 ,  H04L9/002 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/26 ,  Y04S40/24

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

公开(公告)号：US20180299357A1

公开(公告)日：2018-10-18

申请号：US15950979

申请日：2018-04-11

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Bryan J. Kaehr ,  C. Jeffrey Brinker ,  Jason L. Townson

IPC: G01N1/28 ,  C08K3/36 ,  C12N11/14

Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

公开(公告)号：US20180234447A1

公开(公告)日：2018-08-16

申请号：US15750236

申请日：2016-08-04

Applicant: STC.UNM

Inventor： Abdullah MUEEN ,  Nikan CHAVOSHI

IPC: H04L29/06 ,  G06F17/30

CPC classification number: H04L63/1425 ,  G06F16/2255 ,  G06F21/577 ,  G06F2221/034 ,  G06Q50/01 ,  H04L63/1408 ,  H04L2463/144

Abstract: Bots are detected real-time by correlating activity between users using a lag-sensitive hashing technique that captures warping-invariant correlation. Correlated users groups in social media may be found that represent bot behavior with thousands of bot accounts detected in a couple of hours.

公开(公告)号：US10048939B2

公开(公告)日：2018-08-14

申请号：US14907423

申请日：2014-08-28

Applicant: STC.UNM

Inventor： James Plusquellic

IPC: G06F7/58 ,  G09C1/00 ,  H04L9/00 ,  H04L9/08

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

公开(公告)号：US10047135B2

公开(公告)日：2018-08-14

申请号：US14622217

申请日：2015-02-13

Applicant: STC.UNM

Inventor： Yubin Miao

IPC: A61K51/00 ,  A61M36/14 ,  C07K14/68 ,  A61K51/08 ,  A61K45/06 ,  C07K7/54 ,  A61K38/00

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

公开(公告)号：US09934469B1

公开(公告)日：2018-04-03

申请号：US15370224

申请日：2016-12-06

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Yuan Yu Jau ,  Grant Biedermann ,  Ivan Deutsch

IPC: G06N99/00

CPC classification number: G06N99/002

Abstract: A method for preparing an entangled quantum state of an atomic ensemble is provided. The method includes loading each atom of the atomic ensemble into a respective optical trap; placing each atom of the atomic ensemble into a same first atomic quantum state by impingement of pump radiation; approaching the atoms of the atomic ensemble to within a dipole-dipole interaction length of each other; Rydberg-dressing the atomic ensemble; during the Rydberg-dressing operation, exciting the atomic ensemble with a Raman pulse tuned to stimulate a ground-state hyperfine transition from the first atomic quantum state to a second atomic quantum state; and separating the atoms of the atomic ensemble by more than a dipole-dipole interaction length.

公开(公告)号：US09925153B2

公开(公告)日：2018-03-27

申请号：US15036968

申请日：2014-12-05

Applicant: STC.UNM

Inventor： David L Vander Jagt ,  Lorraine M Deck ,  Robert E Royer ,  John E Heidrich

IPC: A61K31/085 ,  A61K31/12 ,  A61K45/06 ,  A61K31/09 ,  A61K31/121 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K9/00 ,  A61K31/05 ,  A61K31/136 ,  A61K31/444

CPC classification number: A61K31/12 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/121 ,  A61K31/136 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/444 ,  A61K45/06

Abstract: The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

公开(公告)号：US09884107B2

公开(公告)日：2018-02-06

申请号：US15331155

申请日：2016-10-21

Applicant: STC.UNM

Inventor： Bryce C. Chackerian ,  David S. Peabody

IPC: A61K39/155 ,  C07K14/005 ,  A61K39/295 ,  A61K39/12 ,  C12N7/00 ,  A61K47/48 ,  A61K39/00

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K39/295 ,  A61K47/69 ,  A61K47/6901 ,  A61K47/6929 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/40 ,  C12N7/00 ,  C12N2760/18523 ,  C12N2760/18534 ,  C12N2795/00023

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of Respiratory Syncytial Virus (RSV) infections and related disorders, including bronchiolitis and viral pneumonia. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against RSV. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against RSV infection, confer immunity against RSV infection, protect against RSV infection, and reduce the likelihood of infection by RSV infection.

公开(公告)号：US20180022805A1

公开(公告)日：2018-01-25

申请号：US15548871

申请日：2016-02-05

Applicant: Bridget S. WILSON ,  Stuart S. WINTER ,  Michael Frank ERASMUS ,  Michael HOROWITZ ,  STC.UNM

Inventor： Bridget S. Wilson ,  Stuart S. Winter ,  Michael Frank Erasmus ,  Michael Horowitz

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The compositions and methods generally involve a composition that includes a pre-B cell receptor (pre-BCR) antagonist and is engineered for expression as a T cell chimeric receptor. In some embodiments, the pre-BCR antagonists can include an anti-pre-BCR antibody.