公开(公告)号：US09116122B2

公开(公告)日：2015-08-25

申请号：US14184661

申请日：2014-02-19

Applicant: Allen D. Parks ,  Scott E. Spence ,  Rose M. Hayden

Inventor： Allen D. Parks ,  Scott E. Spence ,  Rose M. Hayden

IPC: G01N21/55 ,  G01N21/552

CPC classification number: G01N21/553 ,  G01N2201/0683

Abstract: An optical biosensor is provided for detecting a bio-molecular sample by Goos-Hänchen (GH) enhancement of Aharonov-Albert-Vaidman (AAV) amplification to a surface plasmon resonance (SPR) detector. The sensor includes pre- and post-selection polarizers respectively upstream and downstream of a right-isosceles prism with a metal film and a liquid medium disposed on a diagonal side of the prism. Laser light passes through the first polarizer, reflects at the film, passes through the second polarizer and is detected with a shift determined by a pointer estimator to indicate the sample.

Abstract translation: 提供光学生物传感器用于通过对表面等离子体共振（SPR）检测器的Aharonov-Albert-Vaidman（AAV）扩增的Goos-Hänchen（GH）增强来检测生物分子样品。 传感器包括分别在右侧等腰棱镜的上游和下游的预选择和选择后偏振器，金属膜和布置在棱镜的对角线上的液体介质。 激光穿过第一偏振器，在胶片处反射通过第二偏振器，并且由指示器估计器确定的移动被检测以指示样本。

公开(公告)号：US08953162B2

公开(公告)日：2015-02-10

申请号：US13872399

申请日：2013-04-29

Applicant: DEKA Products Limited Partnership

Inventor： Jacob W. Scarpaci ,  Jason M. Sachs ,  Simon C. Helmore

IPC: G01J4/00 ,  G01N21/21 ,  G01J4/04

CPC classification number: G01N21/21 ,  A61M1/14 ,  G01J4/04 ,  G01N21/90 ,  G01N2201/0612 ,  G01N2201/0683

Abstract: Methods and apparatus for concentration determination using polarized light. The apparatus includes a first polarized light source having a first light source polarization axis and a second polarized light source having a second light source polarization axis generally perpendicular to the first light source polarization axis. Also, a first polarized light receiver having a first polarized light receiver polarization axis and configured to measure an intensity of light transmitted from the first light receiver polarizer and a second polarized light receiver having a second polarized light receiver polarization axis substantially perpendicular to the first light receiver polarization axis and configured to measure an intensity of light transmitted from the second light receiver polarizer, wherein the first and second light receiver polarization axes are generally +/−45 degrees relative to the first and second light source polarization axes.

Abstract translation: 使用偏振光进行浓度测定的方法和装置。 该装置包括具有第一光源偏振轴的第一偏振光源和具有大致垂直于第一光源偏振轴的第二光源偏振轴的第二偏振光源。 此外，具有第一偏振光接收偏振轴并被配置为测量从第一光接收偏振器透射的光的强度的第一偏振光接收器和具有基本上垂直于第一光的第二偏振光接收偏振轴的第二偏振光接收器 接收器偏振轴并且被配置为测量从第二光接收偏振器透射的光的强度，其中第一和第二光接收偏振轴相对于第一和第二光源偏振轴通常为+/- 45度。

公开(公告)号：US20140377792A1

公开(公告)日：2014-12-25

申请号：US14364574

申请日：2012-08-06

Applicant: Anjan Kr. Dasgupta ,  Sarita Roy

Inventor： Anjan Kr. Dasgupta ,  Sarita Roy

IPC: G01N21/64 ,  G01N33/58 ,  G01N33/15

CPC classification number: G01N21/64 ,  B01D59/00 ,  G01N15/1459 ,  G01N21/21 ,  G01N21/6445 ,  G01N21/6486 ,  G01N33/15 ,  G01N33/582 ,  G01N2015/0038 ,  G01N2015/149 ,  G01N2201/0683

Abstract: A technique for determining whether or not a fluorescent material exhibits a directionally dependent property, such as anisotropy or chirality, involves illuminating the particle at its excitation wavelength to stimulate fluorescent emission at both a full-frequency (fundamental) wavelength and a half-frequency wavelength. The ratio of the full-frequency signal strength to the half-frequency signal strength provides an indication of the sample's directionally dependent property. This half-frequency spectral analysis can be used to sort anisotropic particles suspended in fluid flowing through a flow cytometer. For instance, the present technique may be used to separate racemic mixtures of chiral enantiomers of cells, pharmaceutical compounds, and other samples.

Abstract translation: 一种用于确定荧光材料是否表现出方向性依赖性（例如各向异性或手性）的技术涉及在其激发波长处照射该颗粒以在全频（基波）波长和半频波长两者处刺激荧光发射 。 全频信号强度与半频信号强度的比值提供了样品的方向依赖性质的指示。 该半频谱分析可用于对流过流式细胞仪的流体中悬浮的各向异性颗粒进行排序。 例如，本技术可用于分离细胞，药物化合物和其它样品的手性对映异构体的外消旋混合物。

公开(公告)号：US20140268103A1

公开(公告)日：2014-09-18

申请号：US14293356

申请日：2014-06-02

Applicant: K Sciences GP, LLC

Inventor： Valentin Korman

IPC: A61B5/145 ,  A61B5/1455 ,  G01N21/21

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/6815 ,  A61B5/7225 ,  A61B2560/0443 ,  A61B2562/0238 ,  G01N21/21 ,  G01N2201/062 ,  G01N2201/0683

Abstract: A glucose sensor comprising an optical energy source having an emitter with an emission pattern; a first polarizer intersecting the emission pattern; a second polarizer spaced a distance from the first polarizer and intersecting the emission pattern, the second polarizer rotated relative to the first polarizer by a first rotational amount Θ; a first optical detector intersecting the emission pattern; a second optical detector positioned proximal to the second polarizer, the first polarizer and the second polarizer being positioned between the optical energy source and the second optical detector, the second optical detector intersecting the emission pattern; a compensating circuit coupled to the second optical detector; and a subtractor circuit coupled to the compensating circuit and the first optical detector.

Abstract translation: 一种葡萄糖传感器，包括具有发射器的光能源，其具有发射图案; 与发射图案相交的第一偏振片; 与第一偏振器间隔开一定距离并与发射图案相交的第二偏振器，第二偏振器相对于第一偏振器相对于第一偏转器旋转第一旋转量Θ; 与发射图案相交的第一光学检测器; 位于第二偏振器附近的第二光学检测器，第一偏振器和第二偏振器位于光能源和第二光学检测器之间，第二光学检测器与发射图案相交; 耦合到所述第二光学检测器的补偿电路; 以及耦合到所述补偿电路和所述第一光学检测器的减法器电路。

公开(公告)号：US20140036264A1

公开(公告)日：2014-02-06

申请号：US13872399

申请日：2013-04-29

Applicant: DEKA Products Limited Partnership

Inventor： Jacob W. Scarpaci ,  Jason M. Sachs ,  Simon C. Helmore

IPC: G01N21/21

CPC classification number: G01N21/21 ,  A61M1/14 ,  G01J4/04 ,  G01N21/90 ,  G01N2201/0612 ,  G01N2201/0683

Abstract: Methods and apparatus for concentration determination using polarized light. The apparatus includes a first polarized light source having a first light source polarization axis and a second polarized light source having a second light source polarization axis generally perpendicular to the first light source polarization axis. Also, a first polarized light receiver having a first polarized light receiver polarization axis and configured to measure an intensity of light transmitted from the first light receiver polarizer and a second polarized light receiver having a second polarized light receiver polarization axis substantially perpendicular to the first light receiver polarization axis and configured to measure an intensity of light transmitted from the second light receiver polarizer, wherein the first and second light receiver polarization axes are generally +/−45 degrees relative to the first and second light source polarization axes.

Abstract translation: 使用偏振光进行浓度测定的方法和装置。 该装置包括具有第一光源偏振轴的第一偏振光源和具有大致垂直于第一光源偏振轴的第二光源偏振轴的第二偏振光源。 此外，具有第一偏振光接收偏振轴并被配置为测量从第一光接收偏振器透射的光的强度的第一偏振光接收器和具有基本上垂直于第一光的第二偏振光接收偏振轴的第二偏振光接收器 接收器偏振轴并且被配置为测量从第二光接收偏振器透射的光的强度，其中第一和第二光接收偏振轴相对于第一和第二光源偏振轴通常为+/- 45度。

公开(公告)号：US20130148119A1

公开(公告)日：2013-06-13

申请号：US13758535

申请日：2013-02-04

Applicant: DEKA Products Limited Partnership

Inventor： Jacob W. Scarpaci

IPC: G01N21/21

CPC classification number: G01N21/21 ,  G01N2201/0683

Abstract: An apparatus and method for determining the concentration of chiral molecules in a fluid includes a first polarizer configure to polarize light in substantially a first plane to provide initially polarized light. A second polarizer is capable of polarizing the initially polarized light in a plurality of planes, at least one of the plurality of planes being different from the first plane, to provide subsequently polarized light. One or more receivers are included for measuring an intensity of the subsequently polarized light in one or more of the plurality of planes.

公开(公告)号：US08159671B2

公开(公告)日：2012-04-17

申请号：US13271014

申请日：2011-10-11

Applicant: Fang Huang

Inventor： Fang Huang

IPC: G01J4/00

CPC classification number: G01N21/23 ,  G01N2021/214 ,  G01N2201/0683

Abstract: A treatment pattern (such as a focused spot, an image, or an interferogram) projected on a treatment target may lose precision if the treatment beam must pass through a birefringent layer before reaching the target. In the general case, the birefringent layer splits the treatment beam into ordinary and extraordinary components, which propagate in different directions and form two patterns, displaced from each other, at the target layer. The degree of birefringence and the orientation of the optic axis, which influence the amount of displacement, often vary between workpieces or between loci on the same workpiece. This invention measures the orientation of the optic axis and uses the data to adjust the treatment beam incidence direction, the treatment beam polarization, or both to superpose the ordinary and extraordinary components into a single treatment pattern at the target, preventing the birefringent layer from causing the pattern to be blurred or doubled.

Abstract translation: 投影在治疗对象上的治疗方式（例如聚焦点，图像，或干涉图）如果在到达目标物体之前必须通过双折射层，则可能失去精度。 在一般情况下，双折射层将处理束分裂成普通和非凡的分量，其在不同方向上传播并在目标层处形成两个相互置换的图案。 影响位移量的光轴的双折射度和取向通常在工件之间或同一工件上的轨迹之间变化。 本发明测量光轴的取向，并使用该数据来调整治疗光束入射方向，治疗束偏振或两者以将普通和非凡成分叠加成靶上的单一处理图案，防止双折射层引起 模式被模糊或加倍。

公开(公告)号：US08040510B2

公开(公告)日：2011-10-18

申请号：US12196455

申请日：2008-08-22

Applicant: Fang Huang

Inventor： Fang Huang

IPC: G01J4/00

CPC classification number: G01N21/23 ,  G01N2021/214 ,  G01N2201/0683

Abstract: A treatment pattern (such as a focused spot, an image, or an interferogram) projected on a treatment target may lose precision if the treatment beam must pass through a birefringent layer before reaching the target. In the general case, the birefringent layer splits the treatment beam into ordinary and extraordinary components, which propagate in different directions and form two patterns, displaced from each other, at the target layer. The degree of birefringence and the orientation of the optic axis, which influence the amount of displacement, often vary between workpieces or between loci on the same workpiece. This invention measures the orientation of the optic axis and uses the data to adjust the treatment beam incidence direction, the treatment beam polarization, or both to superpose the ordinary and extraordinary components into a single treatment pattern at the target, preventing the birefringent layer from causing the pattern to be blurred or doubled.

Abstract translation: 投影在治疗对象上的治疗方式（例如聚焦点，图像，或干涉图）如果在到达目标物体之前必须通过双折射层，则可能失去精度。 在一般情况下，双折射层将处理束分裂成普通和非凡的分量，其在不同方向上传播并在目标层处形成两个相互置换的图案。 影响位移量的光轴的双折射度和取向通常在工件之间或同一工件上的轨迹之间变化。 本发明测量光轴的取向，并使用该数据来调整治疗光束入射方向，治疗束偏振或两者以将普通和非凡成分叠加成靶上的单一处理图案，防止双折射层引起 模式被模糊或加倍。

公开(公告)号：US20100103418A2

公开(公告)日：2010-04-29

申请号：US12263927

申请日：2008-11-03

Applicant: Jacob Scarpaci ,  Jason Sachs ,  Simon Helmore

Inventor： Jacob Scarpaci ,  Jason Sachs ,  Simon Helmore

IPC: G01J4/00

CPC classification number: G01N21/21 ,  A61M1/14 ,  G01J4/04 ,  G01N21/90 ,  G01N2201/0612 ,  G01N2201/0683

Abstract: Methods and apparatus for concentration determination using polarized light. The apparatus includes a first polarized light source having a first light source polarization axis and a second polarized light source having a second light source polarization axis generally perpendicular to the first light source polarization axis. Also, a first polarized light receiver having a first polarized light receiver polarization axis and configured to measure an intensity of light transmitted from the first light receiver polarizer and a second polarized light receiver having a second polarized light receiver polarization axis substantially perpendicular to the first light receiver polarization axis and configured to measure an intensity of light transmitted from the second light receiver polarizer, wherein the first and second light receiver polarization axes are generally +/−45 degrees relative to the first and second light source polarization axes.

Abstract translation: 使用偏振光进行浓度测定的方法和装置。 该装置包括具有第一光源偏振轴的第一偏振光源和具有大致垂直于第一光源偏振轴的第二光源偏振轴的第二偏振光源。 此外，具有第一偏振光接收偏振轴并被配置为测量从第一光接收偏振器透射的光的强度的第一偏振光接收器和具有基本上垂直于第一光的第二偏振光接收偏振轴的第二偏振光接收器 接收器偏振轴并且被配置为测量从第二光接收偏振器透射的光的强度，其中第一和第二光接收偏振轴相对于第一和第二光源偏振轴通常为+/- 45度。

公开(公告)号：US11950882B2

公开(公告)日：2024-04-09

申请号：US18069791

申请日：2022-12-21

Applicant: ILLUMISONICS INC.

Inventor： Parsin Haji Reza ,  Kevan Bell

IPC: A61B5/00 ,  A61B1/00 ,  A61B1/06 ,  A61B5/02 ,  A61B5/145 ,  G01N21/17 ,  G01N21/64

CPC classification number: A61B5/0095 ,  A61B1/00004 ,  A61B1/00172 ,  A61B1/0615 ,  A61B5/0035 ,  A61B5/14532 ,  A61B5/14542 ,  G01N21/1702 ,  G01N21/64 ,  A61B1/00117 ,  A61B5/02042 ,  G01N2021/1706 ,  G01N2201/0683 ,  G01N2201/08

Abstract: A photoacoustic remote sensing system for imaging a subsurface structure in a sample, comprising exactly one laser source configured to generate a pulsed or intensity-modulated excitation beam configured to generate ultrasonic pressure signals in the sample at an excitation location, and an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic pressure signals, an optical system configured to focus the excitation beam and the interrogation beam below a surface of the sample, a detector configured to detect the returning portion of the interrogation beam, and a processor configured to calculate an image of the sample based on a detected intensity modulation of the returning portion of the interrogation beam from below the surface of the sample.