公开(公告)号：WO2012118930A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/027213

申请日：2012-03-01

Applicant: IMRA AMERICA, INC. ,  QIAN, Wei ,  MURAKAMI, Makoto ,  ICHIKAWA, Yuki ,  CHE, Yong

Inventor： QIAN, Wei ,  MURAKAMI, Makoto ,  ICHIKAWA, Yuki ,  CHE, Yong

IPC: A61K9/14 ,  G01N21/75 ,  A61K49/00 ,  A61K33/24 ,  C12Q1/00 ,  A61K39/395 ,  A61K38/43 ,  G01N33/53 ,  G01N21/64 ,  G01N21/62 ,  A61P35/00 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00

CPC classification number: A61K49/0002 ,  A61K9/0019 ,  A61K9/1688 ,  A61K41/0057 ,  A61K47/10 ,  B01J13/0034 ,  B01J13/0043 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/64 ,  G01N21/658 ,  G01N33/531 ,  G01N33/54346 ,  G01N2021/3595

Abstract: In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.

Abstract translation: 在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。 随后可以对纳米颗粒进行部分或全面修饰。 该方法包括使用以大块金为源材料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。 这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。 由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

公开(公告)号：WO2012094221A2

公开(公告)日：2012-07-12

申请号：PCT/US2011/067731

申请日：2011-12-29

Applicant: IMRA AMERICA, INC. ,  CHE, Yong ,  MURAKAMI, Makoto ,  GUO, Wei

Inventor： CHE, Yong ,  MURAKAMI, Makoto ,  GUO, Wei

IPC: C04B35/00 ,  B32B5/16 ,  B29B9/02

CPC classification number: C04B35/62695 ,  B22F1/0018 ,  B22F1/02 ,  B22F9/04 ,  B22F2999/00 ,  B82Y30/00 ,  C01G49/04 ,  C01G49/08 ,  C01P2004/04 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2004/80 ,  C04B2235/5436 ,  C04B2235/5445 ,  C04B2235/5454 ,  C09C1/62 ,  C22C29/00 ,  C22C32/00 ,  H01F1/0054 ,  Y10T428/2982 ,  Y10T428/2991 ,  B22F2202/11

Abstract: A composite nanoparticle, for example a nanoparticle containing one or a plurality of cores embedded in another material. A composite nanoparticle can be formed by a one step process that includes: ejecting material from a bulk target material using physical energy source, with the bulk target material disposed in a liquid. Composite nanoparticles are formed by cooling at least a portion of the ejected material in the liquid. The composite fine particles may then be collected from the liquid. A product that includes composite fine particles may be formed with laser ablation, and ultrashort laser ablation may be utilized so as to preserve composite nanoparticle stoichiometry. For applications of the composite fine particles, optical properties and/or magnetic properties may be exploited for various applications.

Abstract translation: 复合纳米颗粒，例如包含嵌入另一种材料中的一个或多个芯的纳米颗粒。 复合纳米颗粒可以通过一步法形成，该方法包括：使用物理能源从大量目标材料中排出材料，其中大量目标材料设置在液体中。 复合纳米颗粒是通过冷却至少一部分喷射的液体中形成的。 然后可以从液体中收集复合细颗粒。 可以通过激光烧蚀形成包括复合细颗粒的产品，并且可以利用超短激光烧蚀以保持复合纳米颗粒的化学计量。 对于复合微粒的应用，可以利用光学性质和/或磁性来进行各种应用。

公开(公告)号：WO2012087710A1

公开(公告)日：2012-06-28

申请号：PCT/US2011/064908

申请日：2011-12-14

Applicant: IMRA AMERICA, INC. ,  THE TRUSTEES OF LELAND STANFORD UNIVERSITY ,  FERMANN, Martin E. ,  JIANG, Jie ,  PHILLIPS, Christopher ,  FEJER, Martin M.

Inventor： FERMANN, Martin E. ,  JIANG, Jie ,  PHILLIPS, Christopher ,  FEJER, Martin M.

IPC: H01S3/10

CPC classification number: G02F1/353 ,  G02F2001/3548 ,  G02F2201/02 ,  G02F2201/16 ,  G02F2203/11 ,  H01S3/0092 ,  H01S3/067 ,  H01S3/06754 ,  H01S3/1608 ,  H01S3/1616

Abstract: Compact laser systems are disclosed which include ultrafast laser sources in combination with nonlinear crystals or waveguides. In some implementations fiber based mid-IR sources producing very short pulses and/or mid-IR sources based on a mode locked fiber lasers are utilized. Some embodiments may include an infrared source with an amplifier system comprising, in combination, a Tm fiber amplifier and an Er fiber amplifier. A difference frequency generator receives outputs from the Er and/or Tm amplifier system, and generates an output comprising a difference frequency. Exemplary applications of the compact, high brightness mid-IR light sources include medical applications, spectroscopy, ranging, sensing and metrology.

Abstract translation: 公开了紧凑的激光系统，其包括与非线性晶体或波导组合的超快激光源。 在一些实现中，利用基于模式锁定光纤激光器产生非常短脉冲和/或中红外光源的基于光纤的中红外光源。 一些实施例可以包括具有放大器系统的红外源，该放大器系统组合包括Tm光纤放大器和Er光纤放大器。 差分频率发生器接收来自Er和/或Tm放大器系统的输出，并产生包括差频的输出。 紧凑的高亮度中红外光源的示例性应用包括医疗应用，光谱学，测距，感测和计量学。

公开(公告)号：WO2011123205A1

公开(公告)日：2011-10-06

申请号：PCT/US2011/026501

申请日：2011-02-28

Applicant: IMRA AMERICA, INC. ,  XU, Jingzhou ,  SOHN, Jin, Young ,  CHO, Gyu, Cheon ,  SHAH, Lawrence

Inventor： XU, Jingzhou ,  SOHN, Jin, Young ,  CHO, Gyu, Cheon ,  SHAH, Lawrence

IPC: B23K26/00

CPC classification number: B23K26/00 ,  Y02P40/57

Abstract: Various embodiments may be used for laser-based modification of target material of a workpiece while advantageously achieving improvements in processing throughput and/or quality. Embodiments of a method of processing may include focusing and directing laser pulses to a region of the workpiece at a pulse width sufficiently short so that material is efficiently removed by nonlinear optical absorption from the region and a quantity of heat affected zone and thermal stress on the material within the region, proximate to the region, or both is reduced relative to a quantity obtainable using a laser with longer pulses. In at least one embodiment, an ultrashort pulse laser system may include at least one of a fiber amplifier or fiber laser. Various embodiments are suitable for at least one of dicing, cutting, scribing, and forming features on or within a composite material.

Abstract translation: 各种实施例可以用于对工件的目标材料进行基于激光的修改，同时有利地实现处理生产量和/或质量的改善。 处理方法的实施例可以包括将激光脉冲聚焦并且以足够短的脉冲宽度将激光脉冲引导到工件的区域，使得通过来自该区域的非线性光学吸收和一定数量的热影响区和热应力有效地去除材料 区域内的材料，邻近区域或两者都相对于使用具有较长脉冲的激光可获得的量减少。 在至少一个实施例中，超短脉冲激光系统可以包括光纤放大器或光纤激光器中的至少一个。 各种实施例适合于在复合材料上或复合材料内的切割，切割，划线和成形特征中的至少一个。

公开(公告)号：WO2011041472A1

公开(公告)日：2011-04-07

申请号：PCT/US2010/050798

申请日：2010-09-30

Applicant: IMRA AMERICA, INC. ,  FERMANN, Martin E. ,  HARTL, Ingmar ,  RUEHL, Axel

Inventor： FERMANN, Martin E. ,  HARTL, Ingmar ,  RUEHL, Axel

IPC: H01S3/00

CPC classification number: H01S3/1106 ,  G01J3/10 ,  G01J3/45 ,  G01J2003/102 ,  G01N21/31 ,  G01N21/3581 ,  G01N21/4795 ,  G01N21/636 ,  G01N21/65 ,  G01N2021/3595 ,  H01S3/067 ,  H01S3/105 ,  H01S3/1068 ,  H01S3/107 ,  H01S3/1115

Abstract: The invention relates to scanning pulsed laser systems for optical imaging. Coherent dual scanning laser systems (CDSL) are disclosed and some applications thereof. Various alternatives for implementation are illustrated. In at least one embodiment a coherent dual scanning laser system (CDSL) includes two passively modelocked fiber oscillators. In some embodiments an effective CDSL is constructed with only one laser. At least one embodiment includes a coherent scanning laser system (CSL) for generating pulse pairs with a time varying time delay. A CDSL, effective CDSL, or CSL may be arranged in an imaging system for one or more of optical imaging, microscopy, micro-spectroscopy and/or THz imaging.

Abstract translation: 本发明涉及用于光学成像的扫描脉冲激光系统。 公开了相干双扫描激光系统（CDSL）及其一些应用。 示出了用于实现的各种替代方案。 在至少一个实施例中，相干双扫描激光系统（CDSL）包括两个被动锁模光纤振荡器。 在一些实施例中，仅使用一个激光器构造有效的CDSL。 至少一个实施例包括用于产生具有时变时间延迟的脉冲对的相干扫描激光系统（CSL）。 用于光学成像，显微镜，微光谱和/或THz成像中的一种或多种的CDSL，有效的CDSL或CSL可以被布置在成像系统中。

公开(公告)号：WO2009148674A1

公开(公告)日：2009-12-10

申请号：PCT/US2009/036789

申请日：2009-03-11

Applicant: IMRA AMERICA, INC. ,  MURAKAMI, Makoto ,  HU, Zhendong ,  LIU, Bing ,  CHE, Yong ,  LIU, Zhenlin ,  UEHARA, Yuzuru

Inventor： MURAKAMI, Makoto ,  HU, Zhendong ,  LIU, Bing ,  CHE, Yong ,  LIU, Zhenlin ,  UEHARA, Yuzuru

IPC: H01L21/44

CPC classification number: C23C14/28 ,  C23C14/08 ,  C23C14/564 ,  H01S3/0057 ,  H01S3/0085 ,  H01S3/2308

Abstract: A method of pulsed laser deposition (PLD) capable of continuously tuning formed-film morphology from that of a nanoparticle aggregate to a smooth thin film free of particles and droplets. The materials that can be synthesized using various embodiments of the invention include, but are not limited to, metals, alloys, metal oxides, and semiconductors. In various embodiments a 'burst' mode of ultrashort pulsed laser ablation and deposition is provided. Tuning of the film morphology is achieved by controlling the burst-mode parameters such as the number of pulses and the time-spacing between the pulses within each burst, the burst repetition rate, and the laser fluence. The system includes an ultrashort pulsed laser, an optical system for delivering a focused onto the target surface with an appropriate energy density, and a vacuum chamber in which the target and the substrate are installed and background gases and their pressures are appropriately adjusted.

Abstract translation: 脉冲激光沉积（PLD）的方法，其能够将形成膜的形态从纳米颗粒聚集体的形态连续调节到没有颗粒和液滴的平滑薄膜。 可以使用本发明的各种实施方案合成的材料包括但不限于金属，合金，金属氧化物和半导体。 在各种实施例中，提供了超短脉冲激光烧蚀和沉积的“突发”模式。 通过控制脉冲串模式参数，例如脉冲数和每个脉冲串内的脉冲之间的时间间隔，脉冲串重复频率和激光能量密度来实现电影形态的调整。 该系统包括超短脉冲激光器，用于以适当的能量密度传递聚焦到目标表面上的光学系统，以及真空室，其中靶和基底被安装在其中，背景气体及其压力被适当调节。

公开(公告)号：WO2009042347A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/074668

申请日：2008-08-28

Applicant: IMRA AMERICA, INC. ,  DONG, Liang ,  LI, Jun ,  MCKAY, Hugh ,  FU, Libin ,  MARCINKEVICIUS, Andrius

Inventor： DONG, Liang ,  LI, Jun ,  MCKAY, Hugh ,  FU, Libin ,  MARCINKEVICIUS, Andrius

IPC: G02B6/02

CPC classification number: G02B6/0288 ,  G02B6/02009 ,  G02B6/02333 ,  G02B6/02357 ,  G02B6/02361 ,  G02B6/02366 ,  G02B6/02371 ,  G02B6/0283 ,  G02B6/14 ,  H01S3/06729 ,  H01S3/06754 ,  H01S3/091 ,  H01S3/11

Abstract: Embodiments of optical fiber may include cladding features that include a material (e.g., fluorine-doped silica glass) that may produce a very low relative refractive index difference with respect to cladding material in which the cladding features are disposed. This relative refractive index difference may be characterized by (ni-n2)/ni, where ni is the index of refraction of the cladding material in which the cladding features are included, and n2 is the index of refraction of the cladding features. In certain embodiments, the relative refractive index difference may be less than about 4.5 x 10"3. In various embodiments, the configuration of the cladding features including, for example, the size and spacing of the cladding features, can be selected to provide for confinement of the fundamental mode yet leakage for the second mode and higher modes, which may provide mode filtering, single mode propagation, and/or low bend loss.

Abstract translation: 光纤的实施例可以包括包括材料（例如氟掺杂石英玻璃）的包层特征，其可以产生相对于其中设置包层特征的包层材料的非常低的相对折射率差。 该相对折射率差可以由（ni-n2）/ ni表征，其中，ni是其中包括包层特征的包层材料的折射率，n2是包层特征的折射率。 在某些实施例中，相对折射率差可以小于约4.5×10 -3。在各种实施例中，可以选择包括例如包层特征的尺寸和间隔的包层特征的构造，以提供 基本模式的限制，但是对于第二模式和更高模式的泄漏，其可以提供模式滤波，单模传播和/或低弯曲损耗。

公开(公告)号：WO2006042312A3

公开(公告)日：2008-11-27

申请号：PCT/US2005036879

申请日：2005-10-12

Applicant: IMRA AMERICA INC ,  HARTER DONALD J ,  CHO GYU C ,  FERMANN MARTIN E ,  HARTL INGMAR

Inventor： HARTER DONALD J ,  CHO GYU C ,  FERMANN MARTIN E ,  HARTL INGMAR

IPC: G02B6/02 ,  H04B10/17 ,  G02F1/35 ,  G02F1/37 ,  H01S3/00 ,  H01S3/06 ,  H01S3/067 ,  H01S3/094 ,  H01S3/10 ,  H01S3/109 ,  H01S3/16 ,  H01S3/23 ,  H01S3/30 ,  H04B10/12

CPC classification number: H01S5/5045 ,  H01S3/005 ,  H01S3/0057 ,  H01S3/0078 ,  H01S3/0085 ,  H01S3/067 ,  H01S3/0675 ,  H01S3/06754 ,  H01S3/094042 ,  H01S3/10023 ,  H01S3/109 ,  H01S3/1616 ,  H01S3/1618 ,  H01S3/1643 ,  H01S3/235

Abstract: An optimized Yb: doped fiber mode-locked oscillator and fiber amplifier system for seeding Nd: or Yb: doped regenerative amplifiers. The pulses are generated in the Yb: or Nd: doped fiber mode-locked oscillator, and may undergo spectral narrowing or broadening, wavelength converting, temporal pulse compression or stretching, pulse attenuation and/or lowering the repetition rate of the pulse train. The conditioned pulses are subsequently coupled into an Yb: or Nd: fiber amplifier. The amplified pulses are stretched before amplification in the regenerative amplifier that is based on an Nd: or Yb: doped solid-state laser material, and then recompressed for output.

Abstract translation: 一种优化的Yb：掺杂光纤锁模振荡器和光纤放大器系统，用于种子Nd：或Yb：掺杂再生放大器。 脉冲在Yb或Nd：掺杂光纤锁模振荡器中产生，并可能经历频谱变窄或变宽，波长转换，时间脉冲压缩或拉伸，脉冲衰减和/或降低脉冲序列的重复率。 调节脉冲随后耦合到Yb或Nd：光纤放大器中。 在基于Nd：或Yb：掺杂的固态激光材料的再生放大器中，放大后的放大脉冲被拉伸，然后再压缩输出。

公开(公告)号：WO2007046833A3

公开(公告)日：2008-10-09

申请号：PCT/US2005046537

申请日：2005-12-20

Applicant: IMRA AMERICA INC ,  SHAH LAWRENCE

Inventor： SHAH LAWRENCE

IPC: H01S3/10

CPC classification number: H01S3/0057 ,  B23K26/0624 ,  G02B6/02138 ,  G02B6/02142 ,  G02B6/02147 ,  G02B6/13

Abstract: Various embodiments described herein relate to a laser source for producing a pulsed laser beam comprising a plurality of ultrashort optical pulses having a variable repetition rate. In one embodiment, the laser source comprises a fiber oscillator, which outputs optical pulses and a pulse stretcher disposed to receive the optical pulses. The optical pulses have an optical pulse width. The pulse stretcher has dispersion that increases the optical pulse width yielding stretched optical pulses. The laser source further comprises a fiber amplifier disposed to receive the stretched optical pulses. The fiber optical amplifier has gain so as to amplify the stretched optical pulses. The laser source includes an automatically adjustable grating compressor having dispersion that reduces the optical pulse width. The grating compressor automatically adjusts this dispersion for different repetition rates.

Abstract translation: 本文描述的各种实施例涉及用于产生脉冲激光束的激光源，其包括具有可变重复率的多个超短光脉冲。 在一个实施例中，激光源包括输出光脉冲的光纤振荡器和布置成接收光脉冲的脉冲展宽器。 光脉冲具有光脉冲宽度。 脉冲展宽器具有增加产生拉伸光脉冲的光脉冲宽度的色散。 激光源还包括光纤放大器，用于接收延伸的光脉冲。 光纤放大器具有增益以便放大拉伸的光脉冲。 激光源包括具有减小光脉冲宽度的色散的自动调节光栅压缩器。 光栅压缩机自动调整不同重复率的色散。

公开(公告)号：WO2008118766A3

公开(公告)日：2008-10-02

申请号：PCT/US2008/057770

申请日：2008-03-21

Applicant: IMRA AMERICA, INC. ,  CHO, Gyu, C. ,  BOUEVITCH, Oleg

Inventor： CHO, Gyu, C. ,  BOUEVITCH, Oleg

IPC: H01S3/00

Abstract: A laser head generating ultrashort pulses is integrated with an active beam steering device in the head. Direct linkage with an application system by means of an adequate interface protocol enables the active device to be controlled directly by the application system.

Abstract translation: 产生超短脉冲的激光头与主动式光束转向装置集成在头中。 通过适当的接口协议与应用系统直接连接，可以使应用系统直接控制主动设备。