公开(公告)号：US20160303283A1

公开(公告)日：2016-10-20

申请号：US15099957

申请日：2016-04-15

Applicant: Worcester Polytechnic Institute

Inventor： Keith A. Gagnon ,  Thomas J. Moutinho, JR. ,  Kevin A. Reyer ,  Alyssa L. Bornstein ,  Megan O'Brien ,  George D. Pins ,  Glenn R. Gaudette

IPC: A61L27/22 ,  A61L27/54 ,  A61L27/38 ,  A61L27/52 ,  B29C33/38 ,  G03F7/32 ,  B29C41/00 ,  B29C41/42 ,  B29C65/00 ,  B29C41/20 ,  G03F7/20 ,  G03F7/38 ,  A61K35/34 ,  B29C33/40

CPC classification number: A61L27/225 ,  A61K35/34 ,  A61L27/3826 ,  A61L27/52 ,  A61L27/54 ,  B29C33/3842 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/405 ,  B29C33/424 ,  B29C41/003 ,  B29C41/20 ,  B29C41/42 ,  B29C65/002 ,  B29K2089/00 ,  B29K2883/00 ,  B29L2031/753 ,  C12N2533/56 ,  G03F7/0002 ,  G03F7/2002 ,  G03F7/32 ,  G03F7/38

Abstract: A scaffold, a method of using the scaffold and a method of preparing the scaffold which may promote the growth or survival of cells and tissues. The scaffold comprises at least one microvascular layer formed from a thin-film fibrin, the microvascular layer configured to sustain and promote growth of cells and having one or more microfluidics channels embedded in the microvascular layer, the channels configured to contain nutrients needed for growth of the cells, and the channels configured to permit diffusion of the nutrients from the channels to the cells.

Abstract translation: 支架，使用支架的方法和制备可促进细胞和组织的生长或存活的支架的方法。 所述支架包括由薄膜纤维蛋白形成的至少一个微血管层，所述微血管层被配置为维持和促进细胞的生长并且具有嵌入在所述微血管层中的一个或多个微流体通道，所述通道被配置成含有生长所需的营养物质 细胞和被配置成允许营养物从通道扩散到细胞的通道。

公开(公告)号：US09408576B2

公开(公告)日：2016-08-09

申请号：US14267177

申请日：2014-05-01

Applicant: Worcester Polytechnic Institute

Inventor： Ki H. Chon ,  Jowoon Chong

IPC: A61B5/00 ,  A61B5/024 ,  A61B5/046

CPC classification number: A61B5/7282 ,  A61B5/02416 ,  A61B5/02438 ,  A61B5/046 ,  A61B5/6898 ,  A61B5/7264

Abstract: Enhanced real-time realizable AF algorithm for accurate detection of, and discrimination between, NSR, AF, PVC, and PAC. The method of these teachings includes an AF detection method having a modified Poincare approach in order to differentiate various patterns of PAC and PVC from NSR and AF. The method of these teachings can also apply to the Kullback-Leibler divergence or the Turning Point Ratio (TPR) to differentiate between various patterns of PAC and PVC from NSR and AF.

Abstract translation: 增强型实时可实现AF算法，用于NSR，AF，PVC和PAC的精确检测和辨别。 这些教导的方法包括具有修改的庞加莱方法的AF检测方法，以便将PAC和PVC的各种图案与NSR和AF区分开。 这些教导的方法也可以应用于Kullback-Leibler发散度或转折点比（TPR），以区分不同类型的PAC和PVC与NSR和AF。

公开(公告)号：US09230221B2

公开(公告)日：2016-01-05

申请号：US13774981

申请日：2013-02-22

Applicant: Worcester Polytechnic Institute

Inventor： Janice D. Gobert ,  Ermal Toto

IPC: G06N5/00 ,  G06F1/00 ,  G06N99/00 ,  G09B7/04 ,  G09B19/00

CPC classification number: G06N99/005 ,  G06F3/013 ,  G09B5/02 ,  G09B7/04 ,  G09B19/00 ,  G09B19/0069

Abstract: A digital instructional environment leverages an infrared eye-tracker to monitor a learner's reading and viewing of text and simulations for subject matter. The system detects out-of-order reading/viewing patterns that could lead to poor comprehension. The digital learning environment communicates with other tutorial components including simulation environments, pedagogical agents and may respond in real-time to such patterns with messages that guide learners (knowledge acquirers) to return to effective reading/viewing patterns so as to promote effective construction of mental model(s) developed during knowledge acquisition/learning.

公开(公告)号：US20140322785A1

公开(公告)日：2014-10-30

申请号：US14273932

申请日：2014-05-09

Applicant: Worcester Polytechnic Institute

Inventor： Christopher R. Lambert ,  W. Grant McGimpsey ,  Raymond L. Page ,  Tanja Dominko

IPC: C12N11/14

CPC classification number: C12N11/14 ,  C12M21/02 ,  C12M21/08 ,  C12M25/16 ,  C12M35/06 ,  C12N1/12 ,  C12N5/0062 ,  C12N13/00 ,  C12N2513/00 ,  C12N2521/00 ,  C12N2529/00 ,  C12N2531/00

Abstract: The invention provides methods for rapid, continuous generation of cells and cell products using magnetically stabilized three-dimensional tissue culture. The invention also pertains to a continuous flow self-regulating closed system bioreactor system for magnetically stabilized three-dimensional tissue culture. The methods described here do not use traditional solid scaffolding for cell culture.

Abstract translation: 本发明提供了使用磁稳定的三维组织培养物快速，连续地产生细胞和细胞产物的方法。 本发明还涉及一种用于磁稳定三维组织培养的连续流动自调节闭合系统生物反应器系统。 这里描述的方法不使用传统的固体支架进行细胞培养。

公开(公告)号：US20040237779A1

公开(公告)日：2004-12-02

申请号：US10804846

申请日：2004-03-19

Applicant: Worcester Polytechnic Institute

Inventor： Yi Hua Ma ,  Ivan P. Mardilovich ,  Erik E. Engwall

IPC: B01D053/22

CPC classification number: B01D69/141 ,  B01D53/228 ,  B01D67/0069 ,  B01D67/0072 ,  B01D67/0086 ,  B01D69/10 ,  B01D69/12 ,  B01D71/022 ,  B01D71/028 ,  B01D2325/04 ,  B01D2325/20 ,  C01B3/505 ,  C01B2203/041 ,  C01B2203/0475

Abstract: The present invention relates to a composite gas separation module and to methods for fabricating a composite gas separation module. The present invention also relates to methods for selectively separating hydrogen gas from a hydrogen gas-containing gaseous stream. In one embodiment, the composite gas separation module includes a porous metal substrate; an intermediate porous metal layer, wherein the intermediate porous metal layer overlies the porous metal substrate; and a dense hydrogen-selective membrane, wherein the dense hydrogen-selective membrane overlies the intermediate porous metal layer. The intermediate porous metal layer can include can include palladium and a Group IB metal. For example, the intermediate porous metal layer can contain alternating layers of palladium and a Group IB metal.

Abstract translation: 本发明涉及一种复合气体分离模块及其制造方法。 本发明还涉及从含氢气的气流中选择性分离氢气的方法。 在一个实施例中，复合气体分离模块包括多孔金属基底; 中间多孔金属层，其中所述中间多孔金属层覆盖在所述多孔金属基板上; 和致密的氢选择性膜，其中致密的氢选择性膜覆盖在中间多孔金属层上。 中间多孔金属层可以包括钯和IB族金属。 例如，中间多孔金属层可以包含钯和IB族金属的交替层。

公开(公告)号：US20020163347A1

公开(公告)日：2002-11-07

申请号：US09822772

申请日：2001-03-30

Applicant: Worcester Polytechnic Institute

Inventor： Reinhold Ludwig ,  Diran Apelian ,  Sergey Makarov

IPC: G01R027/08

CPC classification number: G01N15/12 ,  G01N33/206 ,  G01N2015/1037 ,  G01N2015/1062 ,  G01N2015/1272

Abstract: The present invention relates to systems of methods of detecting and measuring inclusions in liquid metals. More particularly, non-metallic inclusions having a conductivity level different from the liquid metal melt are forced to migrate and are collected on a measurement surface using electromagnetic Lorentz forces. The inclusions and their concentrations are detected at the measurement surface using either an electrostatic detection system or an optical detection system.

Abstract translation: 本发明涉及检测和测量液态金属中的夹杂物的方法系统。 更具体地说，导电性与液态金属熔体不同的非金属夹杂物被迫迁移，并使用电磁洛伦兹力将其收集在测量表面上。 使用静电检测系统或光学检测系统在测量表面检测夹杂物及其浓度。

公开(公告)号：AU2240292A

公开(公告)日：1993-01-25

申请号：AU2240292

申请日：1992-06-19

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： PAMELA J. WEATHERS ,  RONALD D CHEETHAM ,  ALEXANDER DIIORIO

IPC: C12N5/04 ,  C12P17/18

公开(公告)号：US20250166837A1

公开(公告)日：2025-05-22

申请号：US18953643

申请日：2024-11-20

Applicant: Worcester Polytechnic Institute

Inventor： Emmanuel Agu ,  Akshay Iyer ,  Raghav Nagpal ,  Apiwat Ditthapron ,  Ziyang Liu ,  Reza Sadaarti ,  Bengisu Tulu ,  Diane Strong ,  Peder Pedersen ,  Raymond Dunn ,  Clifford Lindsay

IPC: G16H50/30 ,  G06F40/279 ,  G06T7/00 ,  G06T11/00 ,  G06V10/44 ,  G06V10/74 ,  G06V10/764 ,  G06V10/774 ,  G06V20/70 ,  G16H30/40

Abstract: A wound care treatment platform and application employs a mobile device and application (“app”) for on-site capture and gathering of wound images from a patient. The mobile device is in wireless communication with a database including health records and data and trained models of wound image classification. Based on a patient image of a wound under care, the image is analyzed for features indicative of wound health and healing progress. The mobile device invokes a plurality of models for providing an accurate and consistent assessment and treatment recommendation, including evaluating the sufficiency of the patient image gathered by the mobile device, normalizing the patient image for adverse or irregular lighting, common in patient dwellings, adjusting for a distance and angle at which the caretaker obtained the image, computing a comprehensive score of wound healing, and rendering an evaluation for referral or continuance of current outpatient care.

公开(公告)号：US12297518B2

公开(公告)日：2025-05-13

申请号：US17719080

申请日：2022-04-12

Applicant: Worcester Polytechnic Institute

Inventor： Yan Wang ,  Jiahui Hou ,  Xiaotu Ma ,  Jinzhao Fu

IPC: C22B26/12 ,  A63B24/00 ,  C01D15/08 ,  C22B3/06 ,  G16H20/30 ,  H01M10/54

Abstract: Lithium recycling from expended Li-Ion batteries occurs thought selective recovery of lithium charge materials from a recycling stream including transition metals used for the charge material. Li recovery includes dissolving the lithium based charge material in an organic acid having a resistance or lack of affinity to dissolution of transition metals, and distilling a leach solution formed from the dissolved charge material for generating a powder including lithium and trace impurities of the transition metals. Sintering of the generated powder forms lithium carbonate and carbonates of the trace impurities that eluded the selective leach, however, since the trace impurities are insoluble in water, the lithium carbonate is recoverable by water washing.

公开(公告)号：US20250122444A1

公开(公告)日：2025-04-17

申请号：US18634107

申请日：2024-04-12

Applicant: Worcester Polytechnic Institute

Inventor： Tabiri K. Asumadu ,  Mobin Vandadi ,  Kwadwo Mensah-Darkwa ,  Emmanuel Gikunoo ,  Samuel Kwofie ,  Desmond E.P. Klenam ,  Nima Rahbar ,  Winston O. Soboyejo

IPC: C10M177/00 ,  C10M103/02 ,  C10N50/08 ,  C10N70/00 ,  C23C8/64

Abstract: A carbon coating such as graphene formed on an article or component forms a reduced friction surface on the component. The graphene forms a superlubricity coating for mitigating friction against engaged, moving surfaces. A metallic component receives a graphene coating resulting from a high temperature biowaste treatment (HTBT) by surrounding the metallic component with a granular biowaste medium defining a carbon source, and heating the metallic component in the biowaste medium for diffusing carbon from the biowaste medium to aggregate on a surface of the component, thereby forming a graphene coating.