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    BEAD MANIPULATIONS ON A DROPLET ACTUATOR
    34.
    发明申请
    BEAD MANIPULATIONS ON A DROPLET ACTUATOR 审中-公开
    喷嘴执行器上的珠子操作

    公开(公告)号：WO2009029561A3

    公开(公告)日：2009-05-22

    申请号：PCT/US2008074151

    申请日：2008-08-25

    Applicant: ADVANCED LIQUID LOGIC INC ,  THWAR PRASANNA ,  ALLEN DWAYNE ,  PAIK PHILIP

    Inventor： THWAR PRASANNA ,  ALLEN DWAYNE ,  PAIK PHILIP

    IPC: B05C5/00 ,  B01J19/00 ,  B05B17/04

    CPC classification number: B01L3/52 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/0668 ,  B01L2300/0864 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0424 ,  B01L2400/0427

    Abstract: A droplet actuator comprising: (a) a base substrate comprising electrodes configured for conducting droplet operations on a droplet operations surface thereof; (b) a droplet comprising one or more beads situated on the droplet operations surface; (c) a barrier arranged in relation to the droplet and the electrodes such that a droplet may be transported away from the beads using one or more droplet operations mediated by one or more of the electrodes while transport of the beads is restrained by a barrier. Related methods and kits are also provided.

    Abstract translation: 一种液滴致动器，包括：（a）基底基底，包括构造成用于在其液滴操作表面上进行液滴操作的电极; （b）包含位于所述液滴操作表面上的一个或多个珠粒的液滴; （c）相对于液滴和电极布置的屏障，使得可以使用由一个或多个电极介导的一个或多个液滴操作将液滴从珠流出，同时珠的传送被屏障限制。 还提供了相关方法和试剂盒。

    USE OF ADDITIVES FOR ENHANCING DROPLET OPERATIONS
    37.
    发明申请
    USE OF ADDITIVES FOR ENHANCING DROPLET OPERATIONS 审中-公开
    使用添加剂来增加滴灌操作

    公开(公告)号：WO2009021173A9

    公开(公告)日：2009-04-16

    申请号：PCT/US2008072604

    申请日：2008-08-08

    Applicant: ADVANCED LIQUID LOGIC INC ,  POLLACK MICHAEL ,  ALLEN DWAYNE ,  SRINIVASAN VIJAY ,  PAMULA VAMSEE

    Inventor： POLLACK MICHAEL ,  ALLEN DWAYNE ,  SRINIVASAN VIJAY ,  PAMULA VAMSEE

    IPC: B01J19/08 ,  B01L3/02 ,  G01N35/00

    CPC classification number: B01L3/502792 ,  B01L2200/141 ,  B01L2300/0645 ,  B01L2400/0415 ,  G01N2035/00277

    Abstract: The invention relates to a droplet actuator with a substrate comprising electrodes arranged for conducting droplet operations on a droplet operations surface of the substrate; a filler fluid phase in contact with the droplet operations surface at least partially surrounding a droplet phase comprising a droplet arranged on one or more of the electrodes, the droplet comprising: (i) a target substance susceptible to loss from the droplet phase into the filler fluid phase; and (ii) an additive which reduces loss of the target substance to the filler fluid phase relative to a corresponding droplet not comprising the additive. The invention also relates to various compositions and methods.

    Abstract translation: 本发明涉及一种液滴致动器，其具有包括布置用于在基板的液滴操作表面上进行液滴操作的电极的基板; 与液滴操作表面接触的填充流体相，至少部分地围绕包含布置在一个或多个电极上的液滴的液滴相，所述液滴包括：（i）易受从液滴相流入填料的目标物质 流体相; 和（ii）相对于不包含添加剂的相应液滴，减少目标物质对填料流体相的损失的添加剂。 本发明还涉及各种组合物和方法。

    DROPLET ACTUATOR LOADING AND TARGET CONCENTRATION
    39.
    发明申请
    DROPLET ACTUATOR LOADING AND TARGET CONCENTRATION 审中-公开
    滴落执行器负载和目标浓度

    公开(公告)号：WO2008118831A8

    公开(公告)日：2008-10-02

    申请号：PCT/US2008/057963

    申请日：2008-03-24

    Applicant: ADVANCED LIQUID LOGIC, INC. ,  PAMULA, Vamsee ,  POLLACK, Michael ,  SRINIVASAN, Vijay

    Inventor： PAMULA, Vamsee ,  POLLACK, Michael ,  SRINIVASAN, Vijay

    IPC: B01L3/00 ,  G01N33/543

    Abstract: A droplet actuator and method of providing a droplet comprising an target substance on the droplet actuator, and including discrete flow and continuous flow functionality. Discrete flow function is controlled by electrodes arranged for conducting droplet operations on a substrate surface. The continuous flow function includes a fluid path (101) arranged for flowing a fluid therethrough. The discrete flow and continuous flow functions may be separated by a barrier (103), including a second fluid path through the barrier. The continuous flow function may include a captux-e surface (501) comprising a component having an affinity for the target substance. Methods of the invention may include flowing a fluid comprising the target substance through the fluid path (101); capturing the target substance on the capture surface (501); and forming a droplet in the discrete flow region via the second fluid path and the electrodes comprising the captured target substance.

    Abstract translation: 液滴致动器和在液滴致动器上提供包含目标物质的液滴的方法，并且包括离散流动和连续流动功能。 离散流动功能由布置为在基板表面上进行液滴操作的电极控制。 连续流动功能包括布置用于使流体流过的流体路径（101）。 离散流动和连续流动功能可以通过屏障（103）分开，屏障（103）包括穿过屏障的第二流体路径。 连续流动功能可以包括包含对目标物质具有亲和力的组分的捕获表面（501）。 本发明的方法可以包括使包含目标物质的流体流过流体路径（101）; 捕获捕获表面（501）上的目标物质; 并且经由第二流体路径和包括捕获的目标物质的电极在离散流动区域中形成液滴。

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