Abstract:
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R5, R6, R7, and R8; J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3alkylene, substituted C1-3alkylene, C2-4alkenylene, and substituted C2-4alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
Abstract:
An adaptive transmission scheme of the channel environment in the multi-antenna wireless transmission system can raise the spectrum use rate and power efficiency of the communication system in fast. Comparing with the traditional single antenna input and single antenna output, the channel environment in MIMO wireless communication system is more complex. When the terminal is moving, the different types of channels between terminal and base station can be gone through and then its capacity can be changed more largely. It is characterized in: at first, obtaining the statistical channel information at the receiving end using the result of channel estimation; then, quantizing and encoding the obtained statistical channel information to get feedback bit information and send the feedback bit information to the transmitting end through a feedback channel; thereby using statistical information, the sending end calculates link self-adapting control parameters, which are used for controlling coding modulation and sending the pre-code; the sending end obtains the digital base band transmission signal using a characteristic mode transmission method and a random virtual space selection transmission method, and the receiving end carries out self-adapting receiving by the same parameters.
Abstract:
A level. A projected plane is generated substantially parallel to a reference plane by a light source rotatably emitting light. A main shaft, having a rotary portion and a pair of protrusions and connecting to the light source, is perpendicular to the projected plane. A universal joint is disposed in a housing with the main shaft rotatably passing therethrough. A level sensor detects inclination of the projected plane deviated from the reference plane and outputs an adjustment signal. An adjustment mechanism has a first movable member and a second movable member crossing each other. The first movable member impels one protrusion along a first axis, and the second movable member impels one protrusion along a second axis perpendicular to the first axis according to the adjustment signal. The main shaft is rotated around the universal joint until perpendicular to the reference plane with the projected plane parallel thereto.
Abstract:
A level. A projected plane is generated substantially parallel to a reference plane by a light source rotatably emitting light. A main shaft, having a rotary portion and a pair of protrusions and connecting to the light source, is perpendicular to the projected plane. A universal joint is disposed in a housing with the main shaft rotatably passing therethrough. A level sensor detects inclination of the projected plane deviated from the reference plane and outputs an adjustment signal. An adjustment mechanism has a first movable member and a second movable member crossing each other. The first movable member impels one protrusion along a first axis, and the second movable member impels one protrusion along a second axis perpendicular to the first axis according to the adjustment signal. The main shaft is rotated around the universal joint until perpendicular to the reference plane with the projected plane parallel thereto.
Abstract:
Based on information associated with users, a social networking system recommends one or more groups for a target user to join or to create. Characteristics of the target user, characteristics of users connected to the target user, characteristics of candidate groups in the social networking system may be used to identify groups for recommendation. The social networking system may provide questions to the target user and recommend a group to the target user based on received answers to the questions. For example, the answers to the provided question identify one or more characteristics of the target user, which are used to select a group for recommendation. Additionally, the social networking system may recommend additional users for the target user to add or invite to a group based on characteristics of the target user, the additional users, and/or the group.
Abstract:
Described is a method for power sharing of a display wall, in particular of a LED display wall having a plurality of display modules, and a plurality of N power supply units, each for driving a number of display modules, whereby during a failure of a first power supply unit of the plurality of N power supply units, the outputs of other power supply units are linked together such that the module or modules driven by the first and failed power supply continue(s) to operate, by redistribution of power from the other power supply units. Power sharing is also described in the context of a method for controlling the status of a display wall, in particular of a LED display wall, controlled by a central unit. The method includes collecting status and/or diagnostic information of the display wall inputted to the central unit; converting the status and/or diagnostic information to a picture; and displaying the picture on the display wall.
Abstract:
A multi-antenna channel estimation method based on polyphase decomposition includes: receiving frequency domain received signals transformed using discrete fourier transformation (DFT) in pilot symbols; performing phase correction on the frequency domain received signals; performing polyphase decomposition on the frequency domain received signals which are corrected using phase correction and acquiring polyphase signals; performing interpolation on the polyphase signals and acquiring the estimation values of the multi-antenna channel parameters with various linear combinations on each frequency; acquiring decorrelation array based on the pilot structure of the transmission antenna and decorrelating the estimation values of the multi-antenna channel parameters with various linear combination on each frequency using the decorrelation array and acquiring channel parameters of the pilot symbols on each frequency; acquiring channel parameters of data symbols based on the channel parameters of the pilot symbols. With the present invention, the inversion problem in multi-antenna channel estimation is avoided with lower complexity, and results of the multi-antenna channel estimation method become more accurate since the DFT and filtering are performed in the interpolation after polyphase decomposition.
Abstract:
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
Abstract:
Disclosed is a transformer control device and method based on a three-dimensional zone diagram policy. The method includes: setting transformers, including a transformer A and a transformer B; collecting three-phase voltage data and three-phase current data in a power system; rectifying the collected three-phase voltage data and the three-phase current data; transferring the data to the latches in a time-transfer method; transferring the data to an A/D converter of a processor to convert analog signals to digital signals; constructing a three-dimensional zone diagram in the processor; determining transformer operating conditions according to positions of points formed by voltage, reactive power factor and substation load; and adjusting the transformers. This invention adopts a simple, easy and clear three-parameter control policy including voltage, power factors and substation loads, so as to simplify analysis of transformer operating conditions, realize optimal substation operation, reduce transformer loss, and increase economic benefits.
Abstract:
A loudspeaker module includes a hollow main body, two rotatable connecting portions, and two loudspeakers. The hollow main body includes two opposite sidewalls. Each of the opposite sidewall defines a first opening, an inner sidewall of the first opening defines an annular rotating slot. One end of the connecting portion extends an annular flange shaped corresponding to the rotating slot. The two rotatable connecting portions are respectively rotatably connected to the main body via the flange rotating about the rotating slot. Two loudspeakers are disposed in an end of the corresponding rotatable connecting portion away from the main body.