公开(公告)号：WO1998003541A1

公开(公告)日：1998-01-29

申请号：PCT/US1997012618

申请日：1997-07-21

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  COGNETIX, INC. ,  ABOGADIE, Fe, C. ,  CRUZ, Lourdes, J. ,  OLIVERA, Baldomero, M. ,  WALKER, Craig ,  COLLEDGE, Clark ,  HILLYARD, David, R. ,  JIMENEZ, Elsie ,  LAYER, Richard, T. ,  ZHOU, Li-Ming ,  SHEN, Gregory, S. ,  McCABE, R., Tyler ,  RIVIER, Jean, E.

Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  COGNETIX, INC.

IPC: C07K05/00

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more gamma -carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.

Abstract translation: 本发明涉及具有10-30个氨基酸，包括优选两个或更多个γ-羧基谷氨酸残基的组合蛋白肽，柯南酮肽衍生物和柯南鸟肽嵌合体，统称为聚对二聚体。 凝血因子可用于治疗神经和精神疾病，例如抗惊厥剂，神经保护剂或止痛剂。

公开(公告)号：WO2006098764A3

公开(公告)日：2007-03-08

申请号：PCT/US2005032129

申请日：2005-09-09

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC ,  MAX PLANCK GESELLSCHAFT ,  OLIVERA BALDOMERO M ,  TERLAU HEINRICH ,  IMPERIAL JULITA S ,  GARRETT JAMES E

Inventor： OLIVERA BALDOMERO M ,  TERLAU HEINRICH ,  IMPERIAL JULITA S ,  GARRETT JAMES E

IPC: C07K14/435 ,  A61K38/17

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The present invention is directed to conopeptides termed conkunitzins and their use for blocking the flow of potassium ions through voltage-gated potassium channels. In view of the Kunitz domain in the conkunitzins, they are also useful for inhibiting platelet aggregation and as protease inhibitors.

Abstract translation: 本发明涉及称为康尼他嗪的肽，以及它们用于阻断钾离子通过电压门控钾通道流动的用途。 鉴于康un嗪中的Kunitz结构域，它们也可用于抑制血小板聚集和蛋白酶抑制剂。

公开(公告)号：WO0207675A3

公开(公告)日：2003-03-06

申请号：PCT/US0123041

申请日：2001-07-23

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  WATKINS MAREN ,  GARRETT JAMES E ,  SHON KI-JOON ,  JACOBSEN RICHARD ,  JONES ROBERT M ,  CARTIER G EDWARD

IPC: C12N15/09 ,  A61K38/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  C07K14/435 ,  C12N15/12 ,  A61K38/17 ,  C02N15/12

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The invention relates to omega -conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents, as cardiovascular agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及ω-多肽，其衍生物或药学上可接受的盐及其用途，包括治疗神经和精神疾病，例如抗惊厥剂，作为神经保护剂，作为心血管药物或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。

公开(公告)号：WO02064740A9

公开(公告)日：2003-01-23

申请号：PCT/US0203887

申请日：2002-02-11

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  WATKINS MAREN ,  GARRETT JAMES E ,  CRUZ LOURDES J ,  GRILLEY MICHELLE ,  WALKER CRAIG S ,  SHETTY RESHMA ,  JONES ROBERT M ,  SCHOENFELD ROBERT M

IPC: A61K38/00 ,  C07K14/435 ,  C12N5/02 ,  C12N

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及芋螺毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。

公开(公告)号：WO2002060923A3

公开(公告)日：2002-08-08

申请号：PCT/US2002/002523

申请日：2002-01-29

Applicant: COGNETIX, INC. ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： JONES, Robert, M. ,  OLIVERA, Baldomero, M. ,  WATKINS, Maren ,  GARRETT, James, E.

IPC: A61K38/04

Abstract: The present invention is directed to B-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to the nucleic acid sequences encoding the B-superfamily conotoxin peptides and encoding B-superfamily conotoxin propeptides, as well as the B-superfamily conotoxin propeptides.

公开(公告)号：WO2002060923A2

公开(公告)日：2002-08-08

申请号：PCT/US2002/002523

申请日：2002-01-29

Applicant: COGNETIX, INC. ,  UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： JONES, Robert, M. ,  OLIVERA, Baldomero, M. ,  WATKINS, Maren ,  GARRETT, James, E.

IPC: C07K

CPC classification number: C07K14/43504

Abstract: The present invention is directed to B-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to the nucleic acid sequences encoding the B-superfamily conotoxin peptides and encoding B-superfamily conotoxin propeptides, as well as the B-superfamily conotoxin propeptides.

Abstract translation: 本发明涉及B-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码B-超家族荚果毒素肽并编码B-超家族荚果毒素前肽的核酸序列以及B-超家族荚果毒素前肽。

公开(公告)号：DE69911632T2

公开(公告)日：2004-04-29

申请号：DE69911632

申请日：1999-10-20

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND ,  SALK INST FOR BIOLOG STUDIES L

Inventor： CRAIG GREY ,  GRIFFIN DAVID ,  OLIVERA M ,  WATKINS MAREN ,  HILLYARD R ,  IMPERIAL JULITA ,  CRUZ J ,  WAGSTAFF D ,  LAYER T ,  JONES M ,  MCCABE TYLER

IPC: C12N15/09 ,  A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/435 ,  C07K14/575 ,  C12N15/12 ,  A61K38/10 ,  A61K38/16

Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr 10 -contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

公开(公告)号：AU8294501A

公开(公告)日：2002-02-05

申请号：AU8294501

申请日：2001-07-23

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  GARRETT JAMES E ,  WATKINS MAREN ,  CRUZ LOURDES J ,  SHON KI-JOON ,  JACOBSEN RICHARD ,  JONES ROBERT M ,  CARTIER G EDWARD ,  SHEN GREGORY S

IPC: G01N33/50 ,  A61K35/56 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  A61P3/12 ,  A61P9/10 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P21/00 ,  A61P21/02 ,  A61P23/00 ,  A61P23/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P39/00 ,  A61P43/00 ,  C07K14/435 ,  C12N15/09 ,  C12N15/12 ,  G01N33/15 ,  G01N33/58 ,  G01N33/68

公开(公告)号：AU7898201A

公开(公告)日：2002-02-05

申请号：AU7898201

申请日：2001-07-23

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  WATKINS MAREN ,  GARRETT JAMES E ,  SHON KI-JOON ,  JACOBSEN RICHARD ,  JONES ROBERT M ,  CARTIER G EDWARD

IPC: C12N15/09 ,  A61K38/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  C07K14/435 ,  C12N15/12

公开(公告)号：CA2416544A1

公开(公告)日：2002-01-31

申请号：CA2416544

申请日：2001-07-23

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： JACOBSEN RICHARD B ,  CARTIER G EDWARD ,  JONES ROBERT M ,  SHON KI-JOON ,  OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  GARRETT JAMES E ,  CRUZ LOURDES J ,  WATKINS MAREN ,  SHEN GREGORY S ,  WAGSTAFF JOHN D

IPC: G01N33/50 ,  A61K35/56 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  A61P3/12 ,  A61P9/10 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P21/00 ,  A61P21/02 ,  A61P23/00 ,  A61P23/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P39/00 ,  A61P43/00 ,  C07K14/435 ,  C12N15/09 ,  C12N15/12 ,  G01N33/15 ,  G01N33/58 ,  G01N33/68 ,  A61K38/17 ,  C07K14/47 ,  G01N33/53 ,  G01N33/534

Abstract: The present invention is to .mu.-conopeptides, derivatives or pharmaceutical ly acceptable salts thereof. The present invention is further directed to the u se of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the .mu.-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The .mu.-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the .mu.-conopeptides and encoding propeptides, as well a s the propeptides.