公开(公告)号：EP1027055B1

公开(公告)日：2004-01-07

申请号：EP98955131.2

申请日：1998-10-27

Applicant: HOWARD UNIVERSITY

Inventor： SCOTT, Kenneth, R. ,  LAWS, Mia, L. ,  ROBERTS, Ralph, R. ,  NICHOLSON, Jesse, M.

IPC: A61K31/5415 ,  A61P25/08 ,  A61P25/12

CPC classification number: C07D279/20

Abstract: Phenothiazines of formula (I) where R1 is H or -COOR, where R is selected from the group consisting of branched or unbranched alkyl groups containing from 1 to 4 carbon atoms, and where X is selected from H, branched or unbranched alkyl groups containing from 1 to 4 carbons, and halogen, and pharmaceutically acceptable salts thereof. Particularly preferred phenothiazines are those wherein X is hydrogen, chloro, bromo or methyl, R1 is COOR, and R is methyl, ethyl or t-butyl.

公开(公告)号：EP4433884A1

公开(公告)日：2024-09-25

申请号：EP22896529.9

申请日：2022-11-18

Applicant: Howard University

Inventor： OAKLEY, Imani R.

IPC: G05D1/10 ,  B64C39/02 ,  G01C21/20 ,  G05D1/00 ,  B64C3/00 ,  A63H27/00

CPC classification number: B64U2201/1020230101 ,  B64U2101/3120230101 ,  B64U10/40 ,  B64U20/70 ,  B64U20/80 ,  B64U10/14 ,  B64U2201/10420230101 ,  G05D1/101

公开(公告)号：EP3958858A1

公开(公告)日：2022-03-02

申请号：EP20796172.3

申请日：2020-04-27

Applicant: Howard University ,  Georgetown University ,  Ullah, Heyamet ,  Dakshanamurthy, Sivanesan

Inventor： ULLAH, Heyamet ,  DAKSHANAMURTHY, Sivanesan

IPC: A61K31/40 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422

公开(公告)号：EP2847163B1

公开(公告)日：2018-02-21

申请号：EP13787229.7

申请日：2013-03-14

Applicant: Howard University

Inventor： NEKHAI, Sergei ,  KOVALSKYY, Dmytro Borisovych

IPC: C07C337/00 ,  C07C337/08 ,  A61P35/00 ,  C07D213/53

CPC classification number: C07D213/59 ,  C07C337/08 ,  C07D213/53

Abstract: The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.

公开(公告)号：EP3003206A1

公开(公告)日：2016-04-13

申请号：EP14807448.7

申请日：2014-06-06

Applicant: Howard University

Inventor： WANG, Tongxin ,  CHOW, Laurence C.

IPC: A61C11/00

CPC classification number: A61K6/0085 ,  A61K6/083 ,  C08L33/08 ,  C08L33/10 ,  A61K6/0023 ,  C08L33/24

Abstract: A remotely articulated display system for displaying an electronic device has a locking mechanism that is controlled by software installed on the electronic device. The software installed on the electronic device requires a user to supply an authorization input to lock and unlock the electronic device from the display system. Related methods are also disclosed herein, e.g., methods of remotely locking a display via software stored on the device being displayed, methods of locking a display via a multi-stage lock, etc.

Abstract translation: 本文描述了生产水解稳定的树脂单体，生物活性填料，磷偶联剂和表面涂层方法的组合物和方法，其可以组合以产生新一代牙科复合材料; 还描述了包含它们的组合物，以及制备和使用它们的方法。

公开(公告)号：EP2871959A1

公开(公告)日：2015-05-20

申请号：EP13772959.6

申请日：2013-03-15

Applicant: Howard University ,  Dakshanamurthy, Sivanesan ,  Ullah, Hemayet

Inventor： DAKSHANAMURTHY, Sivanesan ,  ULLAH, Hemayet

IPC: A01N43/64 ,  A61K31/41

CPC classification number: A01N43/653 ,  A01N43/38

Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr
248 of the RACK1A protein.

公开(公告)号：EP2691017A2

公开(公告)日：2014-02-05

申请号：EP12764542.2

申请日：2012-03-29

Applicant: Howard University

Inventor： ANDERSON, John M. M.

IPC: A61B5/026

CPC classification number: A61B6/5217 ,  A61B5/02755 ,  A61B6/037 ,  A61B6/481 ,  A61B6/503 ,  A61B6/507 ,  G06F19/00 ,  G06T7/0016 ,  G06T2207/10104 ,  G06T2207/30104 ,  G16H50/50

Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.

公开(公告)号：EP2619330A1

公开(公告)日：2013-07-31

申请号：EP11827554.4

申请日：2011-09-22

Applicant: Howard University

Inventor： CHEN, Yuanxiu

IPC: C12Q1/68 ,  C12Q1/37 ,  C12N9/48

CPC classification number: A61K31/7088 ,  G01N33/507 ,  G01N33/573 ,  G01N2333/948 ,  G01N2410/02

Abstract: The methods provided herein are based on the discovery, as described in more detail herein, that aspartyl aminopeptidase (DAP) is expressed in mammalian pancreatic islet cells and that increased DAP expression results in decreased angiotensin II (Ang II) levels in the islet cells. Methods are provided for identifying compounds effective to increase the expression and/or activity of DAP in mammalian pancreatic islet cells and thereby are effective to decrease Ang II levels in the islet cells. Methods are also provided for decreasing Ang II levels in a subject having Ang II induced pancreas islet cell dysfunction and/or suffering or susceptible to type 1 diabetes, as well as for the treatment or prevention of type 1 diabetes comprising administering to the subject a therapeutically effective amount of the compound identified according to the methods herein.

公开(公告)号：EP2417232A1

公开(公告)日：2012-02-15

申请号：EP10723440.3

申请日：2010-04-05

Applicant: The Boeing Company ,  Howard University

Inventor： MOSLEH, Mohsen ,  BELK, John, H.

IPC: C10M103/00 ,  C10M103/06 ,  C10M125/20 ,  C10M125/22 ,  C10N10/12 ,  C10N20/06 ,  C10N40/22 ,  C10N50/08 ,  C10N70/00

Abstract: A method for reducing wear between two surfaces in sliding contact with one another includes introducing nanoparticles between the two surfaces in an amount and having a composition that results in shear lines being generated within at least one agglomerated wear particle that is generated between the two surfaces as a result of the sliding contact, and subjecting the agglomerated wear particles to at least one load, using at least one of the two surfaces, such that the agglomerated wear particles disassemble along the shear lines into multiple smaller wear particles.

Abstract translation: 并导致剪切线被至少一个凝聚的磨损颗粒内产生一种用于降低两个表面之间的磨损在滑动接触彼此包括将所述两个表面之间的纳米粒子在数量和具有组合物的方法也被两个表面作为之间产生 的至少一个负载，使用两个表面中的至少一个，检测滑动接触，以及使附聚的磨损颗粒的结果做了附聚的磨粒沿剪切线成多个较小的磨损颗粒拆卸。

公开(公告)号：EP1027055A1

公开(公告)日：2000-08-16

申请号：EP98955131.2

申请日：1998-10-27

Applicant: HOWARD UNIVERSITY

Inventor： SCOTT, Kenneth, R. ,  LAWS, Mia, L. ,  ROBERTS, Ralph, R. ,  NICHOLSON, Jesse, M.

IPC: A61K31/54 ,  C07D279/20

CPC classification number: C07D279/20

Abstract: Phenothiazines of formula (I) where R1 is H or -COOR, where R is selected from the group consisting of branched or unbranched alkyl groups containing from 1 to 4 carbon atoms, and where X is selected from H, branched or unbranched alkyl groups containing from 1 to 4 carbons, and halogen, and pharmaceutically acceptable salts thereof. Particularly preferred phenothiazines are those wherein X is hydrogen, chloro, bromo or methyl, R1 is COOR, and R is methyl, ethyl or t-butyl.