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    METHOD OF TREATING DEGENERATIVE DISEASES
    31.
    发明公开
    METHOD OF TREATING DEGENERATIVE DISEASES 审中-公开
    方法治疗退化性疾病的

    公开(公告)号：EP2280722A2

    公开(公告)日：2011-02-09

    申请号：EP09724276.2

    申请日：2009-03-24

    Applicant: Orthologic Corp.

    Inventor： CARNEY, Darrell, H. ,  STEER, Randolph, C.

    IPC: A61K38/48 ,  A61P25/16 ,  A61P27/02

    CPC classification number: A61K38/4833

    Abstract: Agonists of a non-proteolytically activated receptor can be used in methods for treating a disease or disorder in a subject. The methods comprise administering to the subject a therapeutically effective amount of an agonist, wherein the disease or disorder is scleroderma, macular degeneration, diabetic retinopathy, Huntington's disease, Parkinson's disease, closed head trauma, glaucoma, optic neuritis or allograft vasculopathy.

    THROMBIN PEPTIDE DERIVATIVE DIMERS
    32.
    发明授权
    THROMBIN PEPTIDE DERIVATIVE DIMERS 有权
    凝血酶肽的二聚体

    公开(公告)号：EP1539800B1

    公开(公告)日：2007-05-23

    申请号：EP03763062.1

    申请日：2003-07-01

    Applicant: Orthologic Corp.

    Inventor： CARNEY, Darrell, H.

    IPC: C07K5/00 ,  C07K5/10 ,  A61K38/00 ,  A61K38/16

    CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

    Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

    COMBINATION PRO/SUPINATION AND FLEXION THERAPEUTIC MOBILIZATION DEVICE
    33.
    发明公开
    COMBINATION PRO/SUPINATION AND FLEXION THERAPEUTIC MOBILIZATION DEVICE 审中-公开
    治疗仪对于联合PRO /旋后屈曲

    公开(公告)号：EP1289470A2

    公开(公告)日：2003-03-12

    申请号：EP01913450.1

    申请日：2001-03-14

    Applicant: Orthologic Corp.

    Inventor： CULHANE, Jeffrey, J. ,  SOLOMON, Alexander, G. ,  KRUGER, Paul ,  MILOSAVLJEVIC, Dragan ,  COTTERELL, Daniel, E., C. ,  MACPHAIL, Andrew, J.

    IPC: A61H1/02

    CPC classification number: A61H1/0277 ,  A61H2001/0203 ,  A61H2001/0207 ,  A61H2201/0173 ,  A61H2201/018

    Abstract: A therapeutic mobilization device includes a flexion assembly, a pro/supination assembly and a valgus carrying angle compensation device. The flexion assembly has an arm attachment assembly and an elbow actuator and the elbow actuator defines and axes of rotation. The pro/supination assembly is attached to flexion assembly and has a distal forearm attachment assembly and a pro/supination actuator operably connected thereto. The valgus carrying angle compensation device is operably attached to the flexion assembly and the pro/supination assembly. Preferably the pro/supination assembly is slidably mounted on a housing shaft whereby during flexion the pro/supination assembly is free to move along the housing shaft. Further, preferably the arm attachment assembly includes an attachment ring and an adjustable clamp pivotally attached thereto whereby the attachment ring defines a pro/supination axis and the adjustable clamp pivots orthogonally to the pro/supination axis.

    CONTINUOUS PASSIVE MOTION DEVICES FOR JOINTS
    34.
    发明授权
    CONTINUOUS PASSIVE MOTION DEVICES FOR JOINTS 失效
    DEVICE器关节的连续被动运动

    公开(公告)号：EP0863737B1

    公开(公告)日：2000-09-13

    申请号：EP96937150.9

    申请日：1996-11-14

    Applicant: ORTHOLOGIC CORP.

    Inventor： SARINGER, John, H. ,  CULHANE, Jeffrey, J.

    IPC: A61H1/02

    CPC classification number: A61H1/0266 ,  A61H1/0285

    Abstract: The present invention provides continuous passive motion (CPM) devices for joints. An ankle CPM device includes a lower leg support attached at its lower end to a semi-circular track. An actuator slides along the track and can be locked in any desired position on the track. A shaft is pivotally connected at one end thereof to the actuator and a shoe is attached at the other end thereof. When the actuator is positioned at the bottom of the track, the ankle joint of the patient undergoes inversion/eversion motion. When the motor housing is rotated 90 DEG and positioned near the top of the track plantar/dorsi, flexion movement is obtained. A combination of both types of joint movement are obtained for the actuator in intermediate positions. A wrist CPM device includes a brace for the forearm attached to a semi-circular track on which an actuator is mounted. A hand grip is mounted on a semi-circular bracket and a shaft extends between the actuator and a coupling slidably mounted on the semi-circular bracket. With the actuator positioned below the forearm, when the actuator pivots the shaft the wrist joint undergoes ulnar/radial deviation movement and when the motor is rotated 90 DEG and positioned at the side of the arm, extension/flexion movement of the wrist joint is obtained. Positioning the actuator in intermediate positions produces a wrist movement which is a combination of extension/flexion and ulnar/radial deviation of the wrist joint.

    THROMBIN PEPTIDE DERIVATIVES
    36.
    发明公开
    THROMBIN PEPTIDE DERIVATIVES 审中-公开
    THROMBINPEPTIDDERIVATE

    公开(公告)号：EP1539214A4

    公开(公告)日：2008-01-02

    申请号：EP03784751

    申请日：2003-07-01

    Applicant: ORTHOLOGIC CORP

    Inventor： CARNEY DARRELL H

    IPC: A61K38/00 ,  A61K38/48 ,  C07K20060101 ,  C07K7/08 ,  C12N9/74

    CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

    Abstract: Disclosed are thrombin peptide derivatives comprising a polypeptide having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

    ULTRASONIC BONE THERAPY APPARATUS AND METHOD
    37.
    发明公开
    ULTRASONIC BONE THERAPY APPARATUS AND METHOD 失效
    DEVICE AND METHOD FOR骨疗法利用超声

    公开(公告)号：EP0843573A1

    公开(公告)日：1998-05-27

    申请号：EP95937426.0

    申请日：1995-10-04

    Applicant: ORTHOLOGIC CORP.

    Inventor： KAUFMAN, Jonathan, J. ,  CHIABRERA, Allessandro, E.

    IPC: A61N1 ,  A61H23 ,  A61N7 ,  A61B17 ,  A61F2

    CPC classification number: A61N7/00 ,  A61B2017/0015 ,  A61B2017/00172 ,  A61F2002/2864

    Abstract: This invention is a method of ultrasonic bone therapy that subjects a bone (10) to an ultrasonic excitation pulse signal of finite duration, supplied to a transducer (14) next to the bone, and involving a sinusoidal signal in the ultrasonic region to approximately 2 Mhz peculiarly modulated by a sinusoidal signal with frequency between 0 Hz and about 25 kHz; the excitation signal is repeated in the range of 1 Hz to 5000 Hz. The exposure time for therapy is chosen to be in the range of 5 minutes to 1 hour, for 1 time to 3 times a day, for a period of days as necessary for healing or for promoting bone growth and ingrowth. An apparatus for implementing the above method for ultrasonic bone therapy is disclosed comprising a transducer (14) having a transmitting and a receiving element, a special waveform signal generator (20), and a computer (16) for performing the necessary operations defining a preferred treatment regime.

    Medical treatment device
    40.
    发明公开
    Medical treatment device 失效
    Einrichtung und Verfahren zur medizinischen Behandlung。

    公开(公告)号：EP0481761A2

    公开(公告)日：1992-04-22

    申请号：EP91309538.6

    申请日：1991-10-16

    Applicant: OrthoLogic Corp.

    Inventor： Lamond, Donald R. ,  Heinzelman, Bert

    IPC: A61N2/00

    CPC classification number: A61N2/02 ,  A61G13/0045 ,  A61G13/12 ,  A61G13/1235 ,  A61G13/124 ,  A61G13/1245

    Abstract: A medical treatment device (20) is disclosed which includes a medical treatment element (36,38) and resilient securing members (32,34) which adjust or deform to conform to the particular dimensions of that part of the patient's anatomy which is to be treated. The resilient securing members (32, 34) move or deform outwardly away from the patient (22) as the device is applied to conform to the size of the patient and ensure that the patient is centered within the treatment device. The medical treatment elements (36,38) are thus accurately positioned with respect to the patient (22). This is particularly important in treatments involving the application of magnetic fields to the patient (22). In addition, the disclosed medical device (20) is relatively comfortable and can be worn by a patient (22) for a relatively long period of time.
    The invention also extends to the method of applying the medical treatment device (20) to the patient (22).

    Abstract translation: 公开了一种治疗装置（20），其包括医疗处理元件（36,38）和弹性固定构件（32,34），其被调节或变形以符合患者解剖结构的该部分的特定尺寸 对待。 随着装置被施加以符合患者的尺寸并且确保患者在治疗装置内居中，弹性固定构件（32,34）向外远离病人（22）移动或变形。 因此医疗处理元件（36,38）相对于患者（22）精确定位。 这在涉及向患者（22）施加磁场的治疗中尤其重要。 此外，所公开的医疗装置（20）相对舒适并且可以由患者（22）佩戴较长时间段。 本发明还延伸到将医疗装置（20）应用于患者（22）的方法。

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