公开(公告)号：WO2006113914A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/015158

申请日：2006-04-20

Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER ,  ROTH, Mark, B. ,  MORRISON, Mike ,  GOLDMARK, Jesse ,  BLACKSTONE, Eric

Inventor： ROTH, Mark, B. ,  MORRISON, Mike ,  GOLDMARK, Jesse ,  BLACKSTONE, Eric

IPC: A61K33/04 ,  A01N1/00 ,  C12N5/00

CPC classification number: A61K33/04 ,  A01N1/02 ,  A01N1/0226 ,  A61K31/095 ,  A61K31/165 ,  A61K31/185 ,  A61K31/21 ,  A61K31/26 ,  A61K31/275 ,  A61K31/555 ,  A61K31/66 ,  A61K45/06 ,  Y10S514/921 ,  A61K2300/00

Abstract: The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.

Abstract translation: 本发明涉及氧还原剂和其它活性化合物在体内或整个生物体中的细胞，组织和/或器官中的用途，除了提高其生存性之外。 它包括组合物，方法，制品和用于提高生存能力的装置，以及用于在这些生物材料中的任何一种中实现淤滞或止血，从而保护和/或保护它们。 在具体实施方案中，还使用所述活性化合物进行器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停搏，神经变性，低温和癌症的治疗方法和装置。

公开(公告)号：WO2005039291A3

公开(公告)日：2005-08-25

申请号：PCT/US2004035289

申请日：2004-10-22

Applicant: HUTCHINSON FRED CANCER RES ,  ROTH MARK B

Inventor： ROTH MARK B

IPC: A01N1/02 ,  A61K33/00 ,  A61K33/04 ,  A61K51/00 ,  B65D81/20 ,  C12M1/04 ,  C12N5/00 ,  C12N5/06 ,  C12N15/06

CPC classification number: C12N5/00 ,  A01N1/02 ,  A01N1/0221 ,  C12N2500/02

Abstract: The present invention concerns the use of oxygen antagonists for inducing stasis in cells. It includes methods and apparatuses for achieving stasis in cells, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for storing platelets is provided.

Abstract translation: 本发明涉及氧拮抗剂在细胞中诱导淤滞的用途。 它包括在细胞中实现淤滞的方法和装置，以保护和/或保护它们。 在具体实施方案中，提供了用于储存血小板的保存方法和装置。

公开(公告)号：WO2005041656A2

公开(公告)日：2005-05-12

申请号：PCT/US2004/035034

申请日：2004-10-22

Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER ,  ROTH, Mark, B.

Inventor： ROTH, Mark, B.

IPC: A01N1/02

CPC classification number: C12N5/00 ,  A01N1/02 ,  A01N1/0221 ,  C12N2500/02

Abstract: The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.

Abstract translation: 本发明涉及氧拮抗剂用于诱导组织中包括全部或部分器官停滞的用途。 它包括用于在组织中实现停滞的方法和设备，以保存和/或保护它们。 在具体实施方案中，提供了用于为移植目的保存组织的保存方法和装置。

公开(公告)号：WO2002101018A2

公开(公告)日：2002-12-19

申请号：PCT/US2002/018518

申请日：2002-06-10

Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER ,  ROTH, Mark, B. ,  PADILLA, Pamela

Inventor： ROTH, Mark, B. ,  PADILLA, Pamela

IPC: C12N

CPC classification number: G01N33/5011 ,  A01N1/02 ,  A01N1/0278 ,  C12N1/04 ,  G01N33/5082 ,  G01N33/5088

Abstract: The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.

Abstract translation: 本发明涉及在缺氧或缺氧条件下培养生物材料以诱导淤滞或悬浮动画的组合物和方法。 包括筛选引起淤滞的化合物或增加瘀血能力的化合物的方法。 这种方法具有保护生物材料以及减少或预防生物材料创伤的后果。 还考虑了用于筛选在缺氧条件下比正常氧条件下活性或更有活性的化合物的方法。 这样的方法可用于鉴定将在其中肿瘤细胞存活的缺氧条件下操作的抗肿瘤化合物。